======= CCL21 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCL21
  * **<color #00a2e8>Official Name</color>**: C-C motif chemokine ligand 21
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6366|6366]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00585|O00585]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCL21&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCL21|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602737|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of myeloid dendritic cell chemotaxis|
|negative regulation of dendritic cell dendrite assembly|
|positive regulation of myeloid dendritic cell chemotaxis|
|CCR7 chemokine receptor binding|
|dendritic cell dendrite assembly|
|mesangial cell-matrix adhesion|
|regulation of dendritic cell dendrite assembly|
|negative regulation of leukocyte tethering or rolling|
|chemokine (C-C motif) ligand 21 signaling pathway|
|negative regulation of leukocyte adhesion to vascular endothelial cell|
|establishment of T cell polarity|
|positive regulation of dendritic cell antigen processing and presentation|
|establishment of lymphocyte polarity|
|negative regulation of dendritic cell apoptotic process|
|chemokine receptor binding|
|positive regulation of dendritic cell chemotaxis|
|regulation of leukocyte tethering or rolling|
|negative regulation of cellular extravasation|
|positive regulation of antigen processing and presentation|
|regulation of dendritic cell chemotaxis|
|regulation of dendritic cell apoptotic process|
|regulation of dendritic cell antigen processing and presentation|
|positive regulation of pseudopodium assembly|
|immunological synapse formation|
|regulation of pseudopodium assembly|
|positive regulation of T cell chemotaxis|
|regulation of T cell chemotaxis|
|dendritic cell chemotaxis|
|regulation of leukocyte adhesion to vascular endothelial cell|
|positive regulation of glycoprotein biosynthetic process|
|positive regulation of cell adhesion mediated by integrin|
|regulation of antigen processing and presentation|
|dendritic cell migration|
|positive regulation of lymphocyte chemotaxis|
|positive regulation of glycoprotein metabolic process|
|response to prostaglandin E|
|positive regulation of neutrophil chemotaxis|
|ruffle organization|
|negative regulation of plasma membrane bounded cell projection assembly|
|regulation of lymphocyte chemotaxis|
|positive regulation of granulocyte chemotaxis|
|CCR chemokine receptor binding|
|regulation of cellular extravasation|
|positive regulation of neutrophil migration|
|regulation of neutrophil chemotaxis|
|positive regulation of filopodium assembly|
|response to prostaglandin|
|positive regulation of T cell migration|
|positive regulation of phosphatidylinositol 3-kinase activity|
|positive regulation of lipid kinase activity|
|regulation of neutrophil migration|
|positive regulation of lymphocyte migration|
|regulation of glycoprotein biosynthetic process|
|monocyte chemotaxis|
|regulation of granulocyte chemotaxis|
|regulation of T cell migration|
|negative regulation of leukocyte migration|
|regulation of filopodium assembly|
|regulation of glycoprotein metabolic process|
|negative regulation of leukocyte apoptotic process|
|regulation of cell adhesion mediated by integrin|
|lymphocyte chemotaxis|
|positive regulation of phospholipid metabolic process|
|mononuclear cell migration|
|chemokine activity|
|positive regulation of cell-matrix adhesion|
|positive regulation of receptor-mediated endocytosis|
|regulation of phosphatidylinositol 3-kinase activity|
|T cell costimulation|
|release of sequestered calcium ion into cytosol|
|lymphocyte costimulation|
|negative regulation of sequestering of calcium ion|
|regulation of lipid kinase activity|
|regulation of lymphocyte migration|
|lymphocyte migration|
|calcium ion transmembrane import into cytosol|
|cell-cell recognition|
|calcium ion transport into cytosol|
|chemokine-mediated signaling pathway|
|cell|
|regulation of leukocyte apoptotic process|
|neutrophil chemotaxis|
|regulation of phospholipid metabolic process|
|response to fatty acid|
|positive regulation of leukocyte chemotaxis|
|granulocyte chemotaxis|
|cytosolic calcium ion transport|
|response to chemokine|
|cellular response to chemokine|
|neutrophil migration|
|positive regulation of actin filament polymerization|
|activation of GTPase activity|
|positive regulation of endocytosis|
|regulation of receptor-mediated endocytosis|
|granulocyte migration|
|positive regulation of plasma membrane bounded cell projection assembly|
|regulation of leukocyte chemotaxis|
|regulation of cell-matrix adhesion|
|establishment of cell polarity|
|positive regulation of cell-substrate adhesion|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of sequestering of calcium ion|
|cell-matrix adhesion|
|myeloid leukocyte migration|
|positive regulation of protein polymerization|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|positive regulation of JNK cascade|
|positive regulation of lipid metabolic process|
|leukocyte chemotaxis|
|cell maturation|
|cellular response to interferon-gamma|
|positive regulation of protein kinase B signaling|
|regulation of actin filament polymerization|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|cellular response to interleukin-1|
|negative regulation of cell-cell adhesion|
|negative regulation of cell projection organization|
|response to interferon-gamma|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|cell-substrate adhesion|
|regulation of JNK cascade|
|response to ketone|
|regulation of leukocyte migration|
|establishment or maintenance of cell polarity|
|positive regulation of supramolecular fiber organization|
|calcium ion transmembrane transport|
|response to interleukin-1|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|positive regulation of T cell activation|
|regulation of endocytosis|
|cell chemotaxis|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of cell-substrate adhesion|
|regulation of chemotaxis|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of protein kinase B signaling|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|response to alcohol|
|regulation of stress-activated MAPK cascade|
|T cell activation|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|cell recognition|
|developmental maturation|
|cellular response to tumor necrosis factor|
|positive regulation of protein complex assembly|
|calcium ion transport|
|positive regulation of cell-cell adhesion|
|negative regulation of cell migration|
|regulation of actin filament organization|
|response to tumor necrosis factor|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|positive regulation of cytosolic calcium ion concentration|
|regulation of ERK1 and ERK2 cascade|
|divalent metal ion transport|
|regulation of leukocyte cell-cell adhesion|
|divalent inorganic cation transport|
|negative regulation of cellular component movement|
|regulation of T cell activation|
|negative regulation of locomotion|
|regulation of cytosolic calcium ion concentration|
|regulation of actin cytoskeleton organization|
|response to acid chemical|
|regulation of supramolecular fiber organization|
|positive regulation of lymphocyte activation|
|regulation of cellular component size|
|leukocyte migration|
|positive regulation of cell projection organization|
|lymphocyte activation|
|regulation of actin filament-based process|
|regulation of lipid metabolic process|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of GTPase activity|
|positive regulation of cell activation|
|cellular calcium ion homeostasis|
|negative regulation of immune system process|
|plasma membrane bounded cell projection assembly|
|calcium ion homeostasis|
|regulation of protein complex assembly|
|cell projection assembly|
|cellular divalent inorganic cation homeostasis|
|regulation of GTPase activity|
|divalent inorganic cation homeostasis|
|inflammatory response|
|positive regulation of cell migration|
|regulation of lymphocyte activation|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|chemotaxis|
|regulation of vesicle-mediated transport|
|taxis|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|positive regulation of kinase activity|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|cation transmembrane transport|
|positive regulation of organelle organization|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|regulation of cell activation|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|cation homeostasis|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|regulation of cellular response to stress|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|innate immune response|
|positive regulation of hydrolase activity|
|ion homeostasis|
|regulation of protein kinase activity|
|cation transport|
|regulation of cell migration|
|response to lipid|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|ion transmembrane transport|
|defense response to other organism|
|regulation of cellular component biogenesis|
|cell migration|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|cell activation|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|cell projection organization|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|transmembrane transport|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|ion transport|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7723
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCL21 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>