======= CCL26 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCL26
  * **<color #00a2e8>Official Name</color>**: C-C motif chemokine ligand 26
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10344|10344]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y258|Q9Y258]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCL26&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCL26|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604697|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Chemoattractant for eosinophils and basophils (PubMed:10415065, PubMed:10488147). Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils (PubMed:10415065, PubMed:10488147, PubMed:11425309). {ECO:0000269|PubMed:10415065, ECO:0000269|PubMed:10488147, ECO:0000269|PubMed:11425309}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CCR3 chemokine receptor binding|
|T cell chemotaxis|
|eosinophil chemotaxis|
|eosinophil migration|
|T cell migration|
|CCR chemokine receptor binding|
|receptor ligand activity|
|monocyte chemotaxis|
|lymphocyte chemotaxis|
|mononuclear cell migration|
|chemokine activity|
|lymphocyte migration|
|chemokine-mediated signaling pathway|
|neutrophil chemotaxis|
|granulocyte chemotaxis|
|response to chemokine|
|cellular response to chemokine|
|neutrophil migration|
|positive regulation of actin filament polymerization|
|positive regulation of endothelial cell proliferation|
|granulocyte migration|
|myeloid leukocyte migration|
|positive regulation of protein polymerization|
|regulation of endothelial cell proliferation|
|positive regulation of chemotaxis|
|leukocyte chemotaxis|
|cellular response to interferon-gamma|
|regulation of actin filament polymerization|
|cellular response to interleukin-1|
|response to interferon-gamma|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of epithelial cell proliferation|
|positive regulation of supramolecular fiber organization|
|response to interleukin-1|
|cell chemotaxis|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|cellular response to tumor necrosis factor|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|response to tumor necrosis factor|
|regulation of ERK1 and ERK2 cascade|
|regulation of epithelial cell proliferation|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of cellular component size|
|leukocyte migration|
|regulation of actin filament-based process|
|positive regulation of GTPase activity|
|regulation of protein complex assembly|
|regulation of GTPase activity|
|inflammatory response|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|positive regulation of response to external stimulus|
|positive regulation of organelle organization|
|cytokine-mediated signaling pathway|
|regulation of MAPK cascade|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of cell migration|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|defense response to other organism|
|regulation of cellular component biogenesis|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.06|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6925
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCL26 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>