======= CCL4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCL4
  * **<color #00a2e8>Official Name</color>**: C-C motif chemokine ligand 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6351|6351]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13236|P13236]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCL4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCL4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182284|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. {ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:12070155, ECO:0000269|PubMed:8525373}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CCR1 chemokine receptor binding|
|positive regulation of natural killer cell chemotaxis|
|CCR5 chemokine receptor binding|
|regulation of natural killer cell chemotaxis|
|negative regulation by host of viral transcription|
|eosinophil chemotaxis|
|positive regulation of lymphocyte chemotaxis|
|eosinophil migration|
|negative regulation of viral transcription|
|regulation of lymphocyte chemotaxis|
|CCR chemokine receptor binding|
|positive regulation of lymphocyte migration|
|positive regulation of calcium-mediated signaling|
|monocyte chemotaxis|
|lymphocyte chemotaxis|
|mononuclear cell migration|
|chemokine activity|
|regulation of lymphocyte migration|
|regulation of viral transcription|
|lymphocyte migration|
|modification by host of symbiont morphology or physiology|
|interaction with symbiont|
|chemokine-mediated signaling pathway|
|neutrophil chemotaxis|
|positive regulation of leukocyte chemotaxis|
|granulocyte chemotaxis|
|response to chemokine|
|cellular response to chemokine|
|neutrophil migration|
|regulation of calcium-mediated signaling|
|negative regulation of viral process|
|granulocyte migration|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|regulation of leukocyte chemotaxis|
|positive regulation of calcium ion transport|
|myeloid leukocyte migration|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|leukocyte chemotaxis|
|modification of morphology or physiology of other organism|
|cellular response to interferon-gamma|
|cytokine activity|
|cellular response to interleukin-1|
|response to interferon-gamma|
|regulation of leukocyte migration|
|establishment or maintenance of cell polarity|
|response to interleukin-1|
|regulation of viral process|
|cell chemotaxis|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|cellular response to tumor necrosis factor|
|regulation of calcium ion transport|
|response to tumor necrosis factor|
|positive regulation of ion transport|
|response to virus|
|regulation of ERK1 and ERK2 cascade|
|leukocyte migration|
|regulation of metal ion transport|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|inflammatory response|
|positive regulation of cell migration|
|response to toxic substance|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|positive regulation of response to external stimulus|
|cytokine-mediated signaling pathway|
|regulation of ion transport|
|regulation of MAPK cascade|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cell migration|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|cell migration|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|identical protein binding|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12322
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCL4 Expression in NALM6 Cells: -0.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>