======= CCNA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCNA2
  * **<color #00a2e8>Official Name</color>**: cyclin A2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=890|890]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20248|P20248]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCNA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCNA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123835|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. {ECO:0000269|PubMed:1312467}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cyclin C|
|Cyclin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to cocaine|
|cyclin A2-CDK2 complex|
|cyclin-dependent protein kinase activity|
|cellular response to luteinizing hormone stimulus|
|response to luteinizing hormone|
|male pronucleus|
|cellular response to insulin-like growth factor stimulus|
|female pronucleus|
|cellular response to nitric oxide|
|cellular response to leptin stimulus|
|cellular response to gonadotropin stimulus|
|cellular response to reactive nitrogen species|
|response to nitric oxide|
|cellular response to platelet-derived growth factor stimulus|
|response to platelet-derived growth factor|
|response to leptin|
|response to gonadotropin|
|histone phosphorylation|
|cyclin-dependent protein kinase holoenzyme complex|
|cyclin-dependent protein serine/threonine kinase regulator activity|
|cellular response to alkaloid|
|response to glucagon|
|cellular response to estradiol stimulus|
|positive regulation of fibroblast proliferation|
|response to bronchodilator|
|cochlea development|
|response to cocaine|
|animal organ regeneration|
|response to anesthetic|
|regulation of fibroblast proliferation|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|regulation of DNA replication|
|response to alkaloid|
|cell cycle G1/S phase transition|
|cellular response to ammonium ion|
|G2/M transition of mitotic cell cycle|
|cellular response to reactive oxygen species|
|cell cycle G2/M phase transition|
|response to estradiol|
|regeneration|
|response to ammonium ion|
|cellular response to xenobiotic stimulus|
|cellular response to hypoxia|
|inner ear development|
|response to reactive oxygen species|
|cellular response to decreased oxygen levels|
|cellular response to oxygen levels|
|cellular response to inorganic substance|
|ear development|
|protein kinase activity|
|cellular response to oxidative stress|
|protein domain specific binding|
|Ras protein signal transduction|
|cellular response to peptide hormone stimulus|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|protein deubiquitination|
|protein modification by small protein removal|
|response to xenobiotic stimulus|
|small GTPase mediated signal transduction|
|cellular response to peptide|
|response to hypoxia|
|response to decreased oxygen levels|
|histone modification|
|covalent chromatin modification|
|response to oxygen levels|
|response to oxidative stress|
|response to peptide hormone|
|cellular response to drug|
|protein kinase binding|
|response to peptide|
|cell division|
|cellular response to growth factor stimulus|
|regulation of protein serine/threonine kinase activity|
|cellular response to lipid|
|response to growth factor|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|sensory organ development|
|mitotic cell cycle process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|mitotic cell cycle|
|chromatin organization|
|viral process|
|symbiotic process|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|response to lipid|
|regulation of kinase activity|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|protein phosphorylation|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|chromosome organization|
|response to nitrogen compound|
|response to abiotic stimulus|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|proteolysis|
|phosphorylation|
|cell cycle|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.58|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.55|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-2.31|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-2.29|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.13|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.99|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.84|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.83|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.82|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.79|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.73|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.7|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.7|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.71|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.74|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.77|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.78|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.78|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.79|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.81|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.81|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.85|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.85|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.86|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.87|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.88|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.88|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|1.91|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.94|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.97|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.98|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.99|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.99|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.01|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|2.06|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|2.17|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|2.18|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|2.25|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.4|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.73|
|[[:results:exp224|CB-839 10μM R05 exp224]]|2.86|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb4|PSMB4]]|0.581|
|[[:human genes:t:tceb3c|TCEB3C]]|0.577|
|[[:human genes:c:chd4|CHD4]]|0.575|
|[[:human genes:r:rps2|RPS2]]|0.566|
|[[:human genes:l:lrr1|LRR1]]|0.564|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.558|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.552|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.551|
|[[:human genes:p:psmd2|PSMD2]]|0.55|
|[[:human genes:c:copg1|COPG1]]|0.549|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.549|
|[[:human genes:n:npipb5|NPIPB5]]|0.548|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.548|
|[[:human genes:p:psma6|PSMA6]]|0.547|
|[[:human genes:u:utp3|UTP3]]|0.546|
|[[:human genes:v:vasn|VASN]]|0.544|
|[[:human genes:h:hivep3|HIVEP3]]|0.541|
|[[:human genes:c:cdc45|CDC45]]|0.541|
|[[:human genes:u:upf1|UPF1]]|0.538|
|[[:human genes:m:mt1e|MT1E]]|0.533|
|[[:human genes:n:nupl1|NUPL1]]|0.531|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.53|
|[[:human genes:r:rrp7a|RRP7A]]|0.529|
|[[:human genes:c:chaf1a|CHAF1A]]|0.528|
|[[:human genes:c:cbwd5|CBWD5]]|0.527|
|[[:human genes:c:cbwd3|CBWD3]]|0.525|
|[[:human genes:a:aqr|AQR]]|0.523|
|[[:human genes:o:orc6|ORC6]]|0.519|
|[[:human genes:e:exosc5|EXOSC5]]|0.519|
|[[:human genes:s:snip1|SNIP1]]|0.518|
|[[:human genes:a:aatf|AATF]]|0.517|
|[[:human genes:p:psmd3|PSMD3]]|0.515|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.513|
|[[:human genes:t:tsg101|TSG101]]|0.511|
|[[:human genes:s:slc6a17|SLC6A17]]|0.511|
|[[:human genes:t:tfip11|TFIP11]]|0.511|
|[[:human genes:p:psma7|PSMA7]]|0.51|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.51|
|[[:human genes:c:c14orf93|C14orf93]]|0.508|
|[[:human genes:c:cdca3|CDCA3]]|0.507|
|[[:human genes:d:dtl|DTL]]|0.506|
|[[:human genes:r:rps12|RPS12]]|0.503|
|[[:human genes:p:psmd1|PSMD1]]|0.503|
|[[:human genes:t:tyms|TYMS]]|0.502|
|[[:human genes:c:cln6|CLN6]]|0.502|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.501|
|[[:human genes:p:psmd11|PSMD11]]|0.501|
|[[:human genes:p:psmc2|PSMC2]]|0.5|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.5|
|[[:human genes:p:polr2d|POLR2D]]|0.5|
|[[:human genes:c:ctage4|CTAGE4]]|0.498|
|[[:human genes:p:pola1|POLA1]]|0.497|
|[[:human genes:e:eif4a3|EIF4A3]]|0.496|
|[[:human genes:d:disp2|DISP2]]|0.496|
|[[:human genes:e:exosc9|EXOSC9]]|0.496|
|[[:human genes:s:supt6h|SUPT6H]]|0.496|
|[[:human genes:t:tspy8|TSPY8]]|0.495|
|[[:human genes:c:cbwd6|CBWD6]]|0.494|
|[[:human genes:m:myo1h|MYO1H]]|0.494|
|[[:human genes:r:rps5|RPS5]]|0.493|
|[[:human genes:d:ddx56|DDX56]]|0.491|
|[[:human genes:p:pole|POLE]]|0.491|
|[[:human genes:s:ssh2|SSH2]]|0.49|
|[[:human genes:a:acsf2|ACSF2]]|0.49|
|[[:human genes:p:psmd7|PSMD7]]|0.488|
|[[:human genes:v:vps28|VPS28]]|0.488|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.486|
|[[:human genes:r:rad51|RAD51]]|0.486|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.486|
|[[:human genes:k:kctd17|KCTD17]]|0.486|
|[[:human genes:r:rpl35|RPL35]]|0.485|
|[[:human genes:r:rfc1|RFC1]]|0.485|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.485|
|[[:human genes:n:nsf|NSF]]|0.484|
|[[:human genes:s:snrpa1|SNRPA1]]|0.484|
|[[:human genes:c:cmya5|CMYA5]]|0.483|
|[[:human genes:s:slc4a1|SLC4A1]]|0.483|
|[[:human genes:k:krt78|KRT78]]|0.483|
|[[:human genes:s:supt5h|SUPT5H]]|0.482|
|[[:human genes:b:bysl|BYSL]]|0.482|
|[[:human genes:z:zfand5|ZFAND5]]|0.481|
|[[:human genes:p:polr2j3|POLR2J3]]|0.481|
|[[:human genes:p:psmb2|PSMB2]]|0.479|
|[[:human genes:t:ticrr|TICRR]]|0.478|
|[[:human genes:p:pan3|PAN3]]|0.478|
|[[:human genes:m:myt1l|MYT1L]]|0.477|
|[[:human genes:n:nol12|NOL12]]|0.477|
|[[:human genes:n:nufip2|NUFIP2]]|0.476|
|[[:human genes:a:ankle2|ANKLE2]]|0.476|
|[[:human genes:r:rad21|RAD21]]|0.475|
|[[:human genes:m:mms22l|MMS22L]]|0.475|
|[[:human genes:z:znf830|ZNF830]]|0.475|
|[[:human genes:n:nup133|NUP133]]|0.473|
|[[:human genes:p:psmc1|PSMC1]]|0.472|
|[[:human genes:p:psmc6|PSMC6]]|0.469|
|[[:human genes:n:nop16|NOP16]]|0.469|
|[[:human genes:d:ddtl|DDTL]]|0.469|
|[[:human genes:i:ik|IK]]|0.468|
|[[:human genes:s:sec13|SEC13]]|0.468|
|[[:human genes:e:exosc4|EXOSC4]]|0.468|
|[[:human genes:r:rps20|RPS20]]|0.468|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.468|
|[[:human genes:h:hap1|HAP1]]|0.466|
|[[:human genes:d:dido1|DIDO1]]|0.466|
|[[:human genes:f:fam25b|FAM25B]]|0.466|
|[[:human genes:s:syt9|SYT9]]|0.466|
|[[:human genes:p:psmc5|PSMC5]]|0.466|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.465|
|[[:human genes:m:med14|MED14]]|0.464|
|[[:human genes:x:xylt2|XYLT2]]|0.464|
|[[:human genes:f:fam231c|FAM231C]]|0.464|
|[[:human genes:e:exosc6|EXOSC6]]|0.464|
|[[:human genes:f:fam231a|FAM231A]]|0.463|
|[[:human genes:p:psma1|PSMA1]]|0.461|
|[[:human genes:o:ogfr|OGFR]]|0.46|
|[[:human genes:p:pan2|PAN2]]|0.46|
|[[:human genes:o:orc1|ORC1]]|0.46|
|[[:human genes:p:polr2a|POLR2A]]|0.46|
|[[:human genes:r:rnpc3|RNPC3]]|0.459|
|[[:human genes:r:rps9|RPS9]]|0.459|
|[[:human genes:p:paf1|PAF1]]|0.458|
|[[:human genes:t:twistnb|TWISTNB]]|0.457|
|[[:human genes:c:cdt1|CDT1]]|0.456|
|[[:human genes:l:lad1|LAD1]]|0.456|
|[[:human genes:n:nfatc4|NFATC4]]|0.455|
|[[:human genes:n:nup160|NUP160]]|0.455|
|[[:human genes:a:aamp|AAMP]]|0.454|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.451|
|[[:human genes:n:nol10|NOL10]]|0.45|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.45|
|[[:human genes:c:cope|COPE]]|0.449|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.449|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.449|
|[[:human genes:s:smg7|SMG7]]|0.448|
|[[:human genes:n:nup54|NUP54]]|0.448|
|[[:human genes:t:ttk|TTK]]|0.447|
|[[:human genes:s:sap30bp|SAP30BP]]|0.445|
|[[:human genes:s:stil|STIL]]|0.444|
|[[:human genes:c:ccdc116|CCDC116]]|0.444|
|[[:human genes:c:cdc6|CDC6]]|0.443|
|[[:human genes:p:plk4|PLK4]]|0.443|
|[[:human genes:i:iscu|ISCU]]|0.443|
|[[:human genes:e:exd1|EXD1]]|0.443|
|[[:human genes:m:myo18a|MYO18A]]|0.442|
|[[:human genes:d:dock6|DOCK6]]|0.441|
|[[:human genes:c:ccdc94|CCDC94]]|0.44|
|[[:human genes:r:rrn3|RRN3]]|0.44|
|[[:human genes:s:slc38a7|SLC38A7]]|0.44|
|[[:human genes:m:mat2a|MAT2A]]|0.44|
|[[:human genes:c:col2a1|COL2A1]]|0.439|
|[[:human genes:m:myb|MYB]]|0.439|
|[[:human genes:r:rps10|RPS10]]|0.439|
|[[:human genes:a:art5|ART5]]|0.439|
|[[:human genes:t:ttc1|TTC1]]|0.438|
|[[:human genes:r:rrp15|RRP15]]|0.438|
|[[:human genes:n:nup85|NUP85]]|0.437|
|[[:human genes:r:rbbp5|RBBP5]]|0.437|
|[[:human genes:n:napa|NAPA]]|0.436|
|[[:human genes:r:rps28|RPS28]]|0.436|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.436|
|[[:human genes:p:psmb3|PSMB3]]|0.436|
|[[:human genes:p:phf2|PHF2]]|0.435|
|[[:human genes:i:igfn1|IGFN1]]|0.435|
|[[:human genes:m:mdm2|MDM2]]|0.435|
|[[:human genes:u:uqcrh|UQCRH]]|0.434|
|[[:human genes:g:golga6a|GOLGA6A]]|0.434|
|[[:human genes:h:hmgcr|HMGCR]]|0.434|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.433|
|[[:human genes:g:golga8o|GOLGA8O]]|0.432|
|[[:human genes:c:crnkl1|CRNKL1]]|0.432|
|[[:human genes:r:ranbp2|RANBP2]]|0.432|
|[[:human genes:m:mylk3|MYLK3]]|0.431|
|[[:human genes:s:sart1|SART1]]|0.431|
|[[:human genes:r:rplp1|RPLP1]]|0.431|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.431|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.431|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.429|
|[[:human genes:t:tpx2|TPX2]]|0.429|
|[[:human genes:r:rps7|RPS7]]|0.428|
|[[:human genes:p:psmb1|PSMB1]]|0.428|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.428|
|[[:human genes:c:chmp2a|CHMP2A]]|0.428|
|[[:human genes:c:copb1|COPB1]]|0.428|
|[[:human genes:a:arcn1|ARCN1]]|0.427|
|[[:human genes:a:ankle1|ANKLE1]]|0.427|
|[[:human genes:w:wapal|WAPAL]]|0.426|
|[[:human genes:n:naaladl1|NAALADL1]]|0.426|
|[[:human genes:u:utp20|UTP20]]|0.426|
|[[:human genes:r:rps14|RPS14]]|0.425|
|[[:human genes:s:s1pr4|S1PR4]]|0.425|
|[[:human genes:e:egr2|EGR2]]|0.424|
|[[:human genes:c:cep192|CEP192]]|0.424|
|[[:human genes:z:znf655|ZNF655]]|0.424|
|[[:human genes:z:znf541|ZNF541]]|0.424|
|[[:human genes:c:copz1|COPZ1]]|0.424|
|[[:human genes:c:cdc73|CDC73]]|0.423|
|[[:human genes:k:kif3c|KIF3C]]|0.422|
|[[:human genes:n:npipb8|NPIPB8]]|0.422|
|[[:human genes:g:gid4|GID4]]|0.422|
|[[:human genes:t:terf2|TERF2]]|0.421|
|[[:human genes:t:tonsl|TONSL]]|0.419|
|[[:human genes:g:golga6b|GOLGA6B]]|0.419|
|[[:human genes:r:rpsa|RPSA]]|0.419|
|[[:human genes:x:xab2|XAB2]]|0.419|
|[[:human genes:n:nup205|NUP205]]|0.418|
|[[:human genes:o:osbp|OSBP]]|0.418|
|[[:human genes:r:rpl26|RPL26]]|0.418|
|[[:human genes:o:or10g3|OR10G3]]|0.417|
|[[:human genes:f:fam86b2|FAM86B2]]|0.416|
|[[:human genes:w:wdr87|WDR87]]|0.416|
|[[:human genes:p:psmd8|PSMD8]]|0.416|
|[[:human genes:c:copb2|COPB2]]|0.416|
|[[:human genes:r:rps3a|RPS3A]]|0.415|
|[[:human genes:p:pwp2|PWP2]]|0.414|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.414|
|[[:human genes:p:psmd14|PSMD14]]|0.414|
|[[:human genes:r:rpl14|RPL14]]|0.414|
|[[:human genes:d:dhx38|DHX38]]|0.413|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.413|
|[[:human genes:g:gar1|GAR1]]|0.413|
|[[:human genes:m:mtch2|MTCH2]]|0.413|
|[[:human genes:p:prss8|PRSS8]]|0.412|
|[[:human genes:r:rps19|RPS19]]|0.412|
|[[:human genes:c:cgb2|CGB2]]|0.412|
|[[:human genes:t:timeless|TIMELESS]]|0.412|
|[[:human genes:m:mcm7|MCM7]]|0.411|
|[[:human genes:p:psmc3|PSMC3]]|0.41|
|[[:human genes:a:adrm1|ADRM1]]|0.41|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.408|
|[[:human genes:t:trim52|TRIM52]]|0.408|
|[[:human genes:z:znf675|ZNF675]]|0.408|
|[[:human genes:m:med28|MED28]]|0.408|
|[[:human genes:p:pcf11|PCF11]]|0.408|
|[[:human genes:a:atp13a1|ATP13A1]]|0.407|
|[[:human genes:p:psmd6|PSMD6]]|0.407|
|[[:human genes:g:gpx4|GPX4]]|0.407|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.407|
|[[:human genes:c:ctage9|CTAGE9]]|0.407|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.407|
|[[:human genes:n:ndc80|NDC80]]|0.407|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.406|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.406|
|[[:human genes:m:med17|MED17]]|0.406|
|[[:human genes:g:gosr2|GOSR2]]|0.405|
|[[:human genes:a:ahctf1|AHCTF1]]|0.405|
|[[:human genes:r:rnf113a|RNF113A]]|0.404|
|[[:human genes:s:scgb1c1|SCGB1C1]]|0.404|
|[[:human genes:c:copa|COPA]]|0.403|
|[[:human genes:b:brix1|BRIX1]]|0.402|
|[[:human genes:p:pno1|PNO1]]|0.402|
|[[:human genes:v:vps52|VPS52]]|0.402|
|[[:human genes:k:kpnb1|KPNB1]]|0.402|
|[[:human genes:g:gltscr2|GLTSCR2]]|0.402|
|[[:human genes:w:wdr75|WDR75]]|0.402|
|[[:human genes:p:polr2f|POLR2F]]|0.402|
|[[:human genes:n:numa1|NUMA1]]|0.401|
|[[:human genes:t:traip|TRAIP]]|0.401|
|[[:human genes:p:pold1|POLD1]]|0.401|
|[[:human genes:c:chchd3|CHCHD3]]|0.401|
|[[:human genes:e:exosc3|EXOSC3]]|0.401|
|[[:human genes:m:mbtd1|MBTD1]]|0.4|
|[[:human genes:t:tspy1|TSPY1]]|0.4|
|[[:human genes:z:znf106|ZNF106]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 709/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|27/28|
|bone|24/26|
|breast|33/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|20/21|
|liver|19/20|
|lung|73/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 666
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCNA2 Expression in NALM6 Cells: 7.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>