======= CCND3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCND3
  * **<color #00a2e8>Official Name</color>**: cyclin D3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=896|896]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30281|P30281]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCND3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCND3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123834|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15358120}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cyclin N|
|Cyclin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cyclin-dependent protein serine/threonine kinase activity|
|cyclin-dependent protein kinase holoenzyme complex|
|positive regulation of cyclin-dependent protein serine/threonine kinase activity|
|cyclin-dependent protein serine/threonine kinase regulator activity|
|positive regulation of cyclin-dependent protein kinase activity|
|positive regulation of G1/S transition of mitotic cell cycle|
|T cell proliferation|
|positive regulation of cell cycle G1/S phase transition|
|regulation of insulin receptor signaling pathway|
|regulation of cellular response to insulin stimulus|
|positive regulation of mitotic cell cycle phase transition|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|positive regulation of cell cycle phase transition|
|leukocyte proliferation|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|regulation of cell cycle G1/S phase transition|
|T cell activation|
|protein kinase activity|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|positive regulation of cell cycle process|
|positive regulation of protein serine/threonine kinase activity|
|positive regulation of cell cycle|
|lymphocyte activation|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|protein kinase binding|
|cell division|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|cell population proliferation|
|positive regulation of kinase activity|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|positive regulation of transferase activity|
|mitotic cell cycle|
|regulation of cell cycle process|
|regulation of protein kinase activity|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|leukocyte activation|
|protein phosphorylation|
|regulation of transferase activity|
|cell cycle process|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|cell activation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|phosphorylation|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.14|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.99|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.75|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.77|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.8|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.82|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.82|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.83|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.85|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.9|
|[[:results:exp285|GW501516 25μM R06 exp285]]|1.96|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.02|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|2.18|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|2.18|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|2.21|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|2.22|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.38|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|2.7|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.47|
|[[:human genes:p:prim1|PRIM1]]|0.453|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 34/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|9/28|
|bone|1/26|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|3/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|6/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 652
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCND3 Expression in NALM6 Cells: 8.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>