======= CCNE2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCNE2
  * **<color #00a2e8>Official Name</color>**: cyclin E2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9134|9134]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O96020|O96020]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCNE2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCNE2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603775|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential for the control of the cell cycle at the late G1 and early S phase.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cyclin C|
|Cyclin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cyclin E2-CDK2 complex|
|cyclin E1-CDK2 complex|
|cyclin-dependent protein kinase holoenzyme complex|
|DNA replication initiation|
|cyclin-dependent protein serine/threonine kinase regulator activity|
|synapsis|
|homologous chromosome segregation|
|chromosome organization involved in meiotic cell cycle|
|meiotic chromosome segregation|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|telomere maintenance|
|telomere organization|
|regulation of cyclin-dependent protein kinase activity|
|meiosis I|
|meiosis I cell cycle process|
|G1/S transition of mitotic cell cycle|
|DNA-dependent DNA replication|
|cell cycle G1/S phase transition|
|meiotic nuclear division|
|meiotic cell cycle process|
|DNA replication|
|nuclear chromosome segregation|
|meiotic cell cycle|
|protein kinase activity|
|mitotic cell cycle phase transition|
|chromosome segregation|
|cell cycle phase transition|
|nuclear division|
|organelle fission|
|anatomical structure homeostasis|
|protein kinase binding|
|centrosome|
|cell division|
|regulation of protein serine/threonine kinase activity|
|regulation of cellular protein localization|
|mitotic cell cycle process|
|mitotic cell cycle|
|DNA metabolic process|
|regulation of protein kinase activity|
|regulation of kinase activity|
|regulation of cellular localization|
|protein phosphorylation|
|regulation of transferase activity|
|cell cycle process|
|regulation of protein localization|
|chromosome organization|
|regulation of cell cycle|
|phosphorylation|
|cell cycle|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|homeostatic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.81|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-1.78|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.72|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.79|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|1.8|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10399
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCNE2 Expression in NALM6 Cells: 6.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>