======= CCR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCR2
  * **<color #00a2e8>Official Name</color>**: C-C motif chemokine receptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=729230|729230]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41597|P41597]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601267|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for the CCL2, CCL7 and CCL13 chemokines (PubMed:23408426). Receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203). Transduces a signal by increasing intracellular calcium ion levels (By similarity). Upon CCL2 ligation, mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). {ECO:0000250|UniProtKB:P51683, ECO:0000269|PubMed:23408426, ECO:0000269|PubMed:23938203, ECO:0000305|PubMed:15995708}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chemokine (C-C motif) ligand 2 binding|
|helper T cell chemotaxis|
|positive regulation of immune complex clearance by monocytes and macrophages|
|T-helper 17 cell chemotaxis|
|chemokine (C-C motif) ligand 12 binding|
|positive regulation of astrocyte chemotaxis|
|negative regulation of eosinophil degranulation|
|chemokine (C-C motif) ligand 7 binding|
|regulation of hematopoietic stem cell migration|
|positive regulation of CD8-positive, alpha-beta T cell extravasation|
|regulation of immune complex clearance by monocytes and macrophages|
|positive regulation of hematopoietic stem cell migration|
|negative regulation of eosinophil activation|
|regulation of astrocyte chemotaxis|
|regulation of eosinophil degranulation|
|regulation of CD8-positive, alpha-beta T cell extravasation|
|positive regulation of thymocyte migration|
|positive regulation of T cell extravasation|
|positive regulation of monocyte extravasation|
|positive regulation of leukocyte tethering or rolling|
|regulation of thymocyte migration|
|regulation of eosinophil activation|
|regulation of monocyte extravasation|
|CCR2 chemokine receptor binding|
|neutrophil clearance|
|monocyte extravasation|
|regulation of T cell extravasation|
|positive regulation of NMDA glutamate receptor activity|
|inflammatory response to wounding|
|regulation of leukocyte tethering or rolling|
|positive regulation of glial cell migration|
|neutrophil homeostasis|
|negative regulation of myeloid leukocyte mediated immunity|
|T cell chemotaxis|
|negative regulation of type 2 immune response|
|negative regulation of leukocyte degranulation|
|positive regulation of leukocyte adhesion to vascular endothelial cell|
|regulation of glial cell migration|
|positive regulation of T cell chemotaxis|
|positive regulation of glutamate receptor signaling pathway|
|regulation of T cell chemotaxis|
|chemokine receptor activity|
|positive regulation of cellular extravasation|
|negative regulation of adenylate cyclase activity|
|positive regulation of monocyte chemotaxis|
|dendritic cell chemotaxis|
|leukocyte adhesion to vascular endothelial cell|
|positive regulation of alpha-beta T cell proliferation|
|regulation of leukocyte adhesion to vascular endothelial cell|
|macrophage migration|
|positive regulation of T-helper 1 type immune response|
|negative regulation of cyclase activity|
|positive regulation of tumor necrosis factor biosynthetic process|
|dendritic cell migration|
|positive regulation of lymphocyte chemotaxis|
|negative regulation of lyase activity|
|C-C chemokine receptor activity|
|chemokine binding|
|C-C chemokine binding|
|positive regulation of mononuclear cell migration|
|regulation of monocyte chemotaxis|
|negative regulation of regulated secretory pathway|
|regulation of lymphocyte chemotaxis|
|regulation of T-helper 1 type immune response|
|T cell migration|
|regulation of adenylate cyclase activity|
|regulation of cellular extravasation|
|regulation of tumor necrosis factor biosynthetic process|
|positive regulation of interleukin-2 production|
|regulation of type 2 immune response|
|homeostasis of number of cells within a tissue|
|regulation of alpha-beta T cell proliferation|
|regulation of T cell cytokine production|
|positive regulation of T cell migration|
|regulation of vascular endothelial growth factor production|
|blood vessel remodeling|
|positive regulation of synaptic transmission, glutamatergic|
|negative regulation of exocytosis|
|positive regulation of signaling receptor activity|
|regulation of NMDA receptor activity|
|positive regulation of lymphocyte migration|
|receptor signaling pathway via JAK-STAT|
|cellular extravasation|
|receptor signaling pathway via STAT|
|monocyte chemotaxis|
|regulation of cyclase activity|
|regulation of T cell migration|
|regulation of lyase activity|
|regulation of mononuclear cell migration|
|lymphocyte chemotaxis|
|mononuclear cell migration|
|negative regulation of leukocyte mediated immunity|
|regulation of leukocyte degranulation|
|leukocyte cell-cell adhesion|
|cellular defense response|
|regulation of interleukin-2 production|
|regulation of myeloid leukocyte mediated immunity|
|positive regulation of alpha-beta T cell activation|
|regulation of lymphocyte migration|
|positive regulation of interferon-gamma production|
|regulation of glutamate receptor signaling pathway|
|lymphocyte migration|
|positive regulation of cytokine biosynthetic process|
|positive regulation of gliogenesis|
|leukocyte homeostasis|
|positive regulation of cation channel activity|
|regulation of synaptic transmission, glutamatergic|
|regulation of T cell mediated immunity|
|regulation of neurotransmitter receptor activity|
|sensory perception of pain|
|chemokine-mediated signaling pathway|
|regulation of cytokine production involved in immune response|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of leukocyte chemotaxis|
|cellular response to chemokine|
|response to chemokine|
|regulation of alpha-beta T cell activation|
|positive regulation of T cell proliferation|
|positive regulation of cold-induced thermogenesis|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|tissue remodeling|
|negative regulation of angiogenesis|
|positive regulation of ion transmembrane transporter activity|
|regulation of cytokine biosynthetic process|
|positive regulation of adaptive immune response|
|negative regulation of blood vessel morphogenesis|
|myeloid cell homeostasis|
|positive regulation of transporter activity|
|regulation of leukocyte chemotaxis|
|negative regulation of vasculature development|
|regulation of gliogenesis|
|negative regulation of immune effector process|
|myeloid leukocyte migration|
|positive regulation of leukocyte migration|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|perikaryon|
|positive regulation of chemotaxis|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|positive regulation of inflammatory response|
|regulation of production of molecular mediator of immune response|
|positive regulation of cation transmembrane transport|
|regulation of cold-induced thermogenesis|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|leukocyte chemotaxis|
|calcium-mediated signaling|
|negative regulation of immune response|
|regulation of tumor necrosis factor production|
|regulation of lymphocyte mediated immunity|
|positive regulation of synaptic transmission|
|regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of ion transmembrane transport|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|regulation of regulated secretory pathway|
|regulation of lymphocyte differentiation|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|negative regulation of leukocyte activation|
|tissue homeostasis|
|regulation of leukocyte migration|
|negative regulation of cell activation|
|homeostasis of number of cells|
|positive regulation of transmembrane transport|
|positive regulation of T cell activation|
|negative regulation of secretion by cell|
|regulation of leukocyte mediated immunity|
|regulation of lymphocyte proliferation|
|cell chemotaxis|
|regulation of mononuclear cell proliferation|
|regulation of chemotaxis|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|regulation of exocytosis|
|negative regulation of secretion|
|positive regulation of cell-cell adhesion|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of leukocyte differentiation|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|regulation of angiogenesis|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|regulation of vasculature development|
|multicellular organismal homeostasis|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|regulation of inflammatory response|
|anatomical structure homeostasis|
|humoral immune response|
|positive regulation of lymphocyte activation|
|neuronal cell body|
|leukocyte migration|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|dendrite|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|negative regulation of immune system process|
|regulation of trans-synaptic signaling|
|positive regulation of cytokine production|
|calcium ion homeostasis|
|regulation of hemopoiesis|
|regulation of immune effector process|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|positive regulation of defense response|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|inflammatory response|
|positive regulation of cell migration|
|cell-cell adhesion|
|regulation of lymphocyte activation|
|positive regulation of cell motility|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|hemopoiesis|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|response to wounding|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|metal ion homeostasis|
|cellular cation homeostasis|
|regulation of cell activation|
|cellular ion homeostasis|
|immune system development|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|viral process|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|regulation of defense response|
|symbiotic process|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of secretion|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|regulation of cell migration|
|positive regulation of immune response|
|protein homodimerization activity|
|cellular homeostasis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|cell migration|
|positive regulation of cell differentiation|
|sensory perception|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|locomotion|
|G protein-coupled receptor signaling pathway|
|defense response|
|positive regulation of developmental process|
|nervous system process|
|integral component of plasma membrane|
|regulation of response to stress|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6144
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCR2 Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>