======= CCR6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCR6
  * **<color #00a2e8>Official Name</color>**: C-C motif chemokine receptor 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1235|1235]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51684|P51684]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCR6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCR6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601835|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988). {ECO:0000250|UniProtKB:O54689, ECO:0000269|PubMed:20068036, ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:25122636, ECO:0000269|PubMed:9169459, ECO:0000303|PubMed:21376174, ECO:0000303|PubMed:25585877}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|isotype switching to IgA isotypes|
|DN3 thymocyte differentiation|
|DN2 thymocyte differentiation|
|thymocyte migration|
|positive regulation of flagellated sperm motility involved in capacitation|
|sperm plasma membrane|
|positive regulation of dendritic cell chemotaxis|
|regulation of dendritic cell chemotaxis|
|positive regulation of cilium-dependent cell motility|
|positive regulation of flagellated sperm motility|
|leukocyte migration involved in inflammatory response|
|chemokine receptor activity|
|regulation of flagellated sperm motility|
|dendritic cell chemotaxis|
|somatic diversification of immunoglobulins involved in immune response|
|somatic recombination of immunoglobulin genes involved in immune response|
|isotype switching|
|dendritic cell migration|
|sperm midpiece|
|sperm principal piece|
|regulation of cilium-dependent cell motility|
|C-C chemokine receptor activity|
|C-C chemokine binding|
|somatic recombination of immunoglobulin gene segments|
|chemokine binding|
|immunoglobulin production involved in immunoglobulin mediated immune response|
|sperm capacitation|
|T cell migration|
|somatic diversification of immunoglobulins|
|somatic cell DNA recombination|
|somatic diversification of immune receptors via germline recombination within a single locus|
|B cell activation involved in immune response|
|sperm flagellum|
|regulation of T cell migration|
|T cell differentiation in thymus|
|somatic diversification of immune receptors|
|cellular defense response|
|regulation of lymphocyte migration|
|lymphocyte migration|
|positive regulation of reproductive process|
|chemokine-mediated signaling pathway|
|positive regulation of leukocyte chemotaxis|
|cellular response to chemokine|
|response to chemokine|
|lymphocyte activation involved in immune response|
|regulation of leukocyte chemotaxis|
|positive regulation of leukocyte migration|
|T cell differentiation|
|positive regulation of chemotaxis|
|positive regulation of epithelial cell migration|
|leukocyte chemotaxis|
|calcium-mediated signaling|
|spermatid development|
|B cell activation|
|spermatid differentiation|
|immunoglobulin production|
|cell maturation|
|regulation of reproductive process|
|production of molecular mediator of immune response|
|regulation of leukocyte migration|
|signaling receptor activity|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|cell chemotaxis|
|regulation of chemotaxis|
|regulation of epithelial cell migration|
|DNA recombination|
|T cell activation|
|lymphocyte differentiation|
|developmental maturation|
|germ cell development|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of cytosolic calcium ion concentration|
|regulation of cytosolic calcium ion concentration|
|leukocyte differentiation|
|second-messenger-mediated signaling|
|humoral immune response|
|cellular process involved in reproduction in multicellular organism|
|leukocyte migration|
|lymphocyte activation|
|external side of plasma membrane|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|inflammatory response|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|spermatogenesis|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|hemopoiesis|
|cellular metal ion homeostasis|
|male gamete generation|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|cell surface|
|metal ion homeostasis|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular cation homeostasis|
|cellular ion homeostasis|
|immune system development|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|gamete generation|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|DNA metabolic process|
|leukocyte mediated immunity|
|ion homeostasis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|regulation of cell migration|
|cellular homeostasis|
|regulation of cell motility|
|leukocyte activation|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|multi-organism reproductive process|
|cellular response to cytokine stimulus|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|positive regulation of immune system process|
|locomotion|
|G protein-coupled receptor signaling pathway|
|defense response|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|movement of cell or subcellular component|
|homeostatic process|
|cell development|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14169
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCR6 Expression in NALM6 Cells: 2.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>