======= CCT5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCT5
  * **<color #00a2e8>Official Name</color>**: chaperonin containing TCP1 subunit 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22948|22948]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48643|P48643]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCT5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCT5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610150|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**:  Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. {ECO:0000269|PubMed:20080638}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cpn60 TCP1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of protein localization to Cajal body|
|positive regulation of protein localization to Cajal body|
|positive regulation of establishment of protein localization to telomere|
|chaperonin-containing T-complex|
|regulation of establishment of protein localization to telomere|
|positive regulation of protein localization to chromosome, telomeric region|
|regulation of establishment of protein localization to chromosome|
|regulation of protein localization to chromosome, telomeric region|
|positive regulation of telomerase RNA localization to Cajal body|
|regulation of telomerase RNA localization to Cajal body|
|G-protein beta-subunit binding|
|mRNA 5-UTR binding|
|positive regulation of telomere maintenance via telomerase|
|binding of sperm to zona pellucida|
|positive regulation of telomere maintenance via telomere lengthening|
|beta-tubulin binding|
|toxin transport|
|positive regulation of telomere maintenance|
|sperm-egg recognition|
|regulation of telomere maintenance via telomerase|
|regulation of telomere maintenance via telomere lengthening|
|positive regulation of DNA biosynthetic process|
|cell-cell recognition|
|cell body|
|positive regulation of protein localization to nucleus|
|mRNA 3-UTR binding|
|regulation of telomere maintenance|
|regulation of DNA biosynthetic process|
|regulation of protein localization to nucleus|
|unfolded protein binding|
|single fertilization|
|fertilization|
|positive regulation of chromosome organization|
|protein stabilization|
|positive regulation of DNA metabolic process|
|protein folding|
|cell recognition|
|response to virus|
|regulation of protein stability|
|microtubule|
|positive regulation of cellular protein localization|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|positive regulation of establishment of protein localization|
|centrosome|
|regulation of cellular protein localization|
|positive regulation of organelle organization|
|regulation of establishment of protein localization|
|sexual reproduction|
|nucleolus|
|regulation of cellular localization|
|multi-organism reproductive process|
|regulation of protein localization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|reproductive process|
|reproduction|
|ATP binding|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-2|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-1.75|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.76|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.92|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.98|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.684|
|[[:human genes:m:mars|MARS]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 465/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|19/28|
|blood|18/28|
|bone|18/26|
|breast|22/33|
|central nervous system|44/56|
|cervix|1/4|
|colorectal|8/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|8/16|
|kidney|16/21|
|liver|16/20|
|lung|39/75|
|lymphocyte|12/16|
|ovary|17/26|
|pancreas|10/24|
|peripheral nervous system|10/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|16/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|11/22|
|urinary tract|14/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 94
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCT5 Expression in NALM6 Cells: 8.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>