======= CD177 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD177
  * **<color #00a2e8>Official Name</color>**: CD177 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57126|57126]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N6Q3|Q8N6Q3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD177&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD177|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/162860|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (PubMed:21193407). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676, PubMed:18462208). By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369). {ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:23202369, ECO:0000269|PubMed:23461681, ECO:0000269|PubMed:28807980}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UPAR LY6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of neutrophil activation|
|positive regulation of neutrophil degranulation|
|neutrophil extravasation|
|regulation of neutrophil degranulation|
|regulation of neutrophil activation|
|cell-cell junction maintenance|
|regulation of integrin-mediated signaling pathway|
|cell junction maintenance|
|positive regulation of superoxide anion generation|
|regulation of superoxide anion generation|
|positive regulation of leukocyte degranulation|
|protein localization to cell surface|
|plasma membrane raft|
|positive regulation of myeloid leukocyte mediated immunity|
|regulation of superoxide metabolic process|
|cellular extravasation|
|cellular component maintenance|
|regulation of leukocyte degranulation|
|leukocyte cell-cell adhesion|
|positive regulation of regulated secretory pathway|
|regulation of myeloid leukocyte mediated immunity|
|calcium-dependent protein binding|
|tertiary granule membrane|
|positive regulation of exocytosis|
|specific granule membrane|
|neutrophil migration|
|positive regulation of reactive oxygen species metabolic process|
|secretory granule membrane|
|granulocyte migration|
|anchored component of membrane|
|protease binding|
|myeloid leukocyte migration|
|integrin binding|
|positive regulation of leukocyte mediated immunity|
|cell-cell junction organization|
|regulation of regulated secretory pathway|
|lamellipodium|
|regulation of reactive oxygen species metabolic process|
|regulation of endocytosis|
|regulation of leukocyte mediated immunity|
|cell junction organization|
|positive regulation of immune effector process|
|regulation of exocytosis|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|blood coagulation|
|coagulation|
|hemostasis|
|leukocyte migration|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of secretion|
|regulation of immune effector process|
|wound healing|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of body fluid levels|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|cell-cell adhesion|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of vesicle-mediated transport|
|response to wounding|
|myeloid leukocyte activation|
|regulation of leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|regulated exocytosis|
|regulation of secretion by cell|
|leukocyte mediated immunity|
|innate immune response|
|exocytosis|
|regulation of secretion|
|positive regulation of immune response|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|cell migration|
|positive regulation of transport|
|secretion by cell|
|export from cell|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of immune system process|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5768
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD177 Expression in NALM6 Cells: -2.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>