======= CD200 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD200
  * **<color #00a2e8>Official Name</color>**: CD200 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4345|4345]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41217|P41217]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD200&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD200|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/155970|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ig|
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of arginase activity|
|positive regulation of arginase activity|
|regulation of protein-glutamine gamma-glutamyltransferase activity|
|regulation of matrix metallopeptidase secretion|
|glycosylated region protein binding|
|negative regulation of matrix metallopeptidase secretion|
|positive regulation of protein-glutamine gamma-glutamyltransferase activity|
|negative regulation of T cell migration|
|protein binding involved in heterotypic cell-cell adhesion|
|negative regulation of macrophage migration|
|negative regulation of interleukin-6 secretion|
|negative regulation of neuroinflammatory response|
|negative regulation of lymphocyte migration|
|negative regulation of macrophage activation|
|positive regulation of transforming growth factor beta production|
|positive regulation of CREB transcription factor activity|
|regulation of neuroinflammatory response|
|regulation of transforming growth factor beta production|
|heterotypic cell-cell adhesion|
|regulation of macrophage migration|
|negative regulation of interleukin-6 production|
|regulation of T cell migration|
|negative regulation of leukocyte migration|
|regulation of macrophage activation|
|regulation of lymphocyte migration|
|negative regulation of cytokine secretion|
|cell body|
|negative regulation of NF-kappaB transcription factor activity|
|negative regulation of protein secretion|
|negative regulation of inflammatory response|
|negative regulation of peptide secretion|
|regulation of interleukin-6 production|
|negative regulation of DNA-binding transcription factor activity|
|negative regulation of leukocyte activation|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|regulation of leukocyte migration|
|negative regulation of cell activation|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|negative regulation of neuron death|
|negative regulation of defense response|
|negative regulation of secretion|
|negative regulation of cell migration|
|positive regulation of DNA-binding transcription factor activity|
|negative regulation of cytokine production|
|negative regulation of cell motility|
|axon|
|negative regulation of cellular component movement|
|regulation of neuron death|
|neuron projection|
|negative regulation of locomotion|
|regulation of inflammatory response|
|negative regulation of response to external stimulus|
|neuronal cell body|
|regulation of DNA-binding transcription factor activity|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|cell-cell adhesion|
|regulation of leukocyte activation|
|cell surface|
|regulation of cell activation|
|positive regulation of transferase activity|
|negative regulation of cell population proliferation|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|positive regulation of hydrolase activity|
|regulation of secretion|
|regulation of cell migration|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|regulation of protein localization|
|regulation of response to external stimulus|
|negative regulation of molecular function|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|regulation of hydrolase activity|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of response to stress|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9315
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD200 Expression in NALM6 Cells: 0.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>