======= CD226 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD226
  * **<color #00a2e8>Official Name</color>**: CD226 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10666|10666]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15762|Q15762]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD226&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD226|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605397|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T- cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705). {ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:8673704}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|
|positive regulation of natural killer cell cytokine production|
|positive regulation of natural killer cell mediated immune response to tumor cell|
|positive regulation of Fc receptor mediated stimulatory signaling pathway|
|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|
|regulation of natural killer cell cytokine production|
|regulation of natural killer cell mediated immune response to tumor cell|
|positive regulation of response to tumor cell|
|positive regulation of immune response to tumor cell|
|regulation of Fc receptor mediated stimulatory signaling pathway|
|regulation of response to tumor cell|
|regulation of immune response to tumor cell|
|positive regulation of T cell receptor signaling pathway|
|positive regulation of mast cell activation|
|positive regulation of antigen receptor-mediated signaling pathway|
|positive regulation of natural killer cell mediated cytotoxicity|
|positive regulation of natural killer cell mediated immunity|
|positive regulation of immunoglobulin mediated immune response|
|positive regulation of B cell mediated immunity|
|regulation of T cell receptor signaling pathway|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of natural killer cell mediated immunity|
|regulation of mast cell activation|
|regulation of B cell mediated immunity|
|regulation of immunoglobulin mediated immune response|
|positive regulation of cytokine production involved in immune response|
|positive regulation of leukocyte mediated cytotoxicity|
|cell adhesion molecule binding|
|regulation of antigen receptor-mediated signaling pathway|
|positive regulation of interferon-gamma production|
|positive regulation of cell killing|
|regulation of leukocyte mediated cytotoxicity|
|regulation of cytokine production involved in immune response|
|positive regulation of production of molecular mediator of immune response|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of cell killing|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|integrin binding|
|positive regulation of leukocyte mediated immunity|
|regulation of production of molecular mediator of immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of lymphocyte mediated immunity|
|cytokine production|
|regulation of adaptive immune response|
|regulation of leukocyte mediated immunity|
|positive regulation of immune effector process|
|membrane raft|
|cell recognition|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|external side of plasma membrane|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of cytokine production|
|regulation of innate immune response|
|protein kinase binding|
|regulation of immune effector process|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|cell surface|
|regulation of cell activation|
|regulation of cytokine production|
|regulation of defense response|
|regulation of multi-organism process|
|positive regulation of immune response|
|cell adhesion|
|biological adhesion|
|regulation of response to external stimulus|
|regulation of immune response|
|positive regulation of immune system process|
|integral component of plasma membrane|
|regulation of response to stress|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12693
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD226 Expression in NALM6 Cells: 3.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>