======= CD28 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD28
  * **<color #00a2e8>Official Name</color>**: CD28 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=940|940]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10747|P10747]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD28&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD28|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/186760|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein complex involved in cell adhesion|
|regulatory T cell differentiation|
|positive regulation of isotype switching to IgG isotypes|
|negative thymic T cell selection|
|positive regulation of inflammatory response to antigenic stimulus|
|negative T cell selection|
|regulation of isotype switching to IgG isotypes|
|positive regulation of interleukin-2 biosynthetic process|
|cytokine biosynthetic process|
|cytokine metabolic process|
|thymic T cell selection|
|regulation of interleukin-2 biosynthetic process|
|positive regulation of alpha-beta T cell proliferation|
|positive regulation of interleukin-4 production|
|regulation of inflammatory response to antigenic stimulus|
|positive regulation of isotype switching|
|regulation of interleukin-4 production|
|regulation of regulatory T cell differentiation|
|regulation of defense response to virus by virus|
|positive regulation of interleukin-2 production|
|regulation of alpha-beta T cell proliferation|
|regulation of isotype switching|
|positive regulation of viral genome replication|
|coreceptor activity|
|immunological synapse|
|positive regulation of interleukin-10 production|
|positive regulation of immunoglobulin mediated immune response|
|positive regulation of B cell mediated immunity|
|T cell selection|
|positive regulation of DNA recombination|
|positive regulation of immunoglobulin production|
|T cell differentiation in thymus|
|regulation of immunoglobulin mediated immune response|
|regulation of B cell mediated immunity|
|regulation of interleukin-10 production|
|positive regulation of mitotic nuclear division|
|SH3/SH2 adaptor activity|
|T cell costimulation|
|regulation of interleukin-2 production|
|lymphocyte costimulation|
|positive regulation of alpha-beta T cell activation|
|positive regulation of viral life cycle|
|regulation of immunoglobulin production|
|positive regulation of nuclear division|
|positive regulation of cytokine biosynthetic process|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|regulation of alpha-beta T cell activation|
|regulation of viral genome replication|
|positive regulation of T cell proliferation|
|positive regulation of production of molecular mediator of immune response|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|protease binding|
|regulation of DNA recombination|
|regulation of cytokine biosynthetic process|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of viral process|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of translation|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte mediated immunity|
|T cell differentiation|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|positive regulation of inflammatory response|
|regulation of production of molecular mediator of immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of viral life cycle|
|cytokine production|
|regulation of lymphocyte mediated immunity|
|positive regulation of cellular amide metabolic process|
|positive regulation of mitotic cell cycle|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|positive regulation of protein kinase B signaling|
|positive regulation of B cell activation|
|regulation of mitotic nuclear division|
|regulation of lymphocyte differentiation|
|T cell receptor signaling pathway|
|regulation of nuclear division|
|positive regulation of DNA metabolic process|
|positive regulation of T cell activation|
|regulation of viral process|
|regulation of leukocyte mediated immunity|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of protein kinase B signaling|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of leukocyte proliferation|
|T cell activation|
|lymphocyte differentiation|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte differentiation|
|apoptotic signaling pathway|
|positive regulation of cell cycle process|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|leukocyte differentiation|
|regulation of inflammatory response|
|humoral immune response|
|regulation of translation|
|regulation of DNA metabolic process|
|positive regulation of lymphocyte activation|
|positive regulation of cell cycle|
|lymphocyte activation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|regulation of cellular amide metabolic process|
|positive regulation of cell activation|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|protein kinase binding|
|regulation of immune effector process|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|posttranscriptional regulation of gene expression|
|hemopoiesis|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|cell surface|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|activation of immune response|
|regulation of cell activation|
|immune system development|
|regulation of cell adhesion|
|regulation of cytokine production|
|viral process|
|regulation of cell cycle process|
|regulation of defense response|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|apoptotic process|
|leukocyte activation|
|negative regulation of cell death|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|identical protein binding|
|cell activation|
|cell death|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|regulation of organelle organization|
|positive regulation of developmental process|
|integral component of plasma membrane|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.49|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2.28|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.98|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.84|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.78|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.77|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.76|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.74|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15550
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD28 Expression in NALM6 Cells: 1.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>