======= CD300A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD300A
  * **<color #00a2e8>Official Name</color>**: CD300a molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11314|11314]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UGN4|Q9UGN4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD300A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD300A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606790|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923). {ECO:0000269|PubMed:10746781, ECO:0000269|PubMed:16339535, ECO:0000269|PubMed:22043923, ECO:0000269|PubMed:9701027}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of activation of Janus kinase activity|
|negative regulation of phagocytosis, engulfment|
|negative regulation of NK T cell activation|
|negative regulation of membrane invagination|
|negative regulation of MyD88-dependent toll-like receptor signaling pathway|
|negative regulation of eosinophil activation|
|negative regulation of eosinophil migration|
|regulation of MyD88-dependent toll-like receptor signaling pathway|
|regulation of eosinophil activation|
|regulation of eosinophil migration|
|negative regulation of neutrophil activation|
|negative regulation of mast cell degranulation|
|negative regulation of B cell receptor signaling pathway|
|regulation of activation of Janus kinase activity|
|negative regulation of mast cell activation involved in immune response|
|regulation of NK T cell activation|
|regulation of neutrophil activation|
|negative regulation of myeloid leukocyte mediated immunity|
|phosphatidylethanolamine binding|
|negative regulation of leukocyte degranulation|
|negative regulation of mast cell activation|
|regulation of phagocytosis, engulfment|
|negative regulation of B cell proliferation|
|regulation of membrane invagination|
|negative regulation of phagocytosis|
|positive regulation of phosphoprotein phosphatase activity|
|negative regulation of regulated secretory pathway|
|regulation of B cell receptor signaling pathway|
|negative regulation of antigen receptor-mediated signaling pathway|
|negative regulation of fibroblast proliferation|
|negative regulation of B cell activation|
|positive regulation of phosphatase activity|
|regulation of mast cell degranulation|
|negative regulation of exocytosis|
|regulation of mast cell activation involved in immune response|
|negative regulation of alpha-beta T cell activation|
|regulation of T cell receptor signaling pathway|
|negative regulation of toll-like receptor signaling pathway|
|negative regulation of endocytosis|
|positive regulation of protein dephosphorylation|
|regulation of mast cell activation|
|negative regulation of leukocyte migration|
|regulation of leukocyte degranulation|
|negative regulation of leukocyte mediated immunity|
|negative regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of dephosphorylation|
|regulation of myeloid leukocyte mediated immunity|
|phosphatidylserine binding|
|negative regulation of intracellular transport|
|ficolin-1-rich granule membrane|
|regulation of B cell proliferation|
|regulation of antigen receptor-mediated signaling pathway|
|regulation of toll-like receptor signaling pathway|
|tertiary granule membrane|
|negative regulation of lymphocyte proliferation|
|negative regulation of MAP kinase activity|
|negative regulation of mononuclear cell proliferation|
|negative regulation of leukocyte proliferation|
|regulation of fibroblast proliferation|
|regulation of alpha-beta T cell activation|
|regulation of phagocytosis|
|negative regulation of T cell activation|
|regulation of phosphoprotein phosphatase activity|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of receptor signaling pathway via JAK-STAT|
|negative regulation of protein serine/threonine kinase activity|
|regulation of receptor signaling pathway via STAT|
|regulation of protein dephosphorylation|
|negative regulation of lymphocyte activation|
|negative regulation of immune response|
|regulation of regulated secretory pathway|
|negative regulation of MAPK cascade|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|regulation of phosphatase activity|
|regulation of leukocyte migration|
|negative regulation of cell activation|
|negative regulation of secretion by cell|
|signaling receptor activity|
|regulation of endocytosis|
|regulation of leukocyte mediated immunity|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of dephosphorylation|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|regulation of exocytosis|
|negative regulation of protein kinase activity|
|negative regulation of secretion|
|negative regulation of kinase activity|
|regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of cell migration|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|negative regulation of transferase activity|
|regulation of leukocyte cell-cell adhesion|
|negative regulation of cellular component movement|
|regulation of T cell activation|
|negative regulation of locomotion|
|regulation of MAP kinase activity|
|regulation of intracellular transport|
|regulation of cell-cell adhesion|
|negative regulation of protein phosphorylation|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of innate immune response|
|regulation of immune effector process|
|negative regulation of transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|negative regulation of intracellular signal transduction|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|regulation of response to biotic stimulus|
|myeloid cell activation involved in immune response|
|regulation of vesicle-mediated transport|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|myeloid leukocyte activation|
|negative regulation of protein modification process|
|regulation of leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulated exocytosis|
|negative regulation of cellular component organization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of cell migration|
|regulation of kinase activity|
|regulation of cell motility|
|regulation of cellular localization|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|negative regulation of cellular protein metabolic process|
|export from cell|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.504|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4659
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD300A Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>