======= CD300LF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD300LF
  * **<color #00a2e8>Official Name</color>**: CD300 molecule like family member f
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=146722|146722]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TDQ1|Q8TDQ1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD300LF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD300LF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609807|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity). {ECO:0000250|UniProtKB:Q6SJQ7, ECO:0000269|PubMed:15549731, ECO:0000269|PubMed:22043923, ECO:0000269|PubMed:24035150}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-13-mediated signaling pathway|
|positive regulation of interleukin-4-mediated signaling pathway|
|negative regulation of MyD88-dependent toll-like receptor signaling pathway|
|negative regulation of apoptotic cell clearance|
|interleukin-4 receptor binding|
|regulation of interleukin-4-mediated signaling pathway|
|cellular response to interleukin-13|
|regulation of MyD88-dependent toll-like receptor signaling pathway|
|ceramide binding|
|response to interleukin-13|
|positive regulation of apoptotic cell clearance|
|regulation of apoptotic cell clearance|
|negative regulation of mast cell activation|
|negative regulation of phagocytosis|
|TRIF-dependent toll-like receptor signaling pathway|
|MyD88-independent toll-like receptor signaling pathway|
|negative regulation of toll-like receptor signaling pathway|
|regulation of mast cell activation|
|positive regulation of cytokine-mediated signaling pathway|
|positive regulation of response to cytokine stimulus|
|phosphatidylserine binding|
|regulation of toll-like receptor signaling pathway|
|positive regulation of phagocytosis|
|regulation of phagocytosis|
|toll-like receptor signaling pathway|
|pattern recognition receptor signaling pathway|
|regulation of cytokine-mediated signaling pathway|
|negative regulation of leukocyte activation|
|regulation of response to cytokine stimulus|
|negative regulation of cell activation|
|innate immune response-activating signal transduction|
|activation of innate immune response|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|negative regulation of immune system process|
|regulation of innate immune response|
|positive regulation of defense response|
|negative regulation of transport|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|regulation of vesicle-mediated transport|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|activation of immune response|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|regulation of defense response|
|regulation of multi-organism process|
|positive regulation of immune response|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|regulation of response to external stimulus|
|response to cytokine|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.71|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.93|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11860
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD300LF Expression in NALM6 Cells: -1.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>