======= CD47 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD47
  * **<color #00a2e8>Official Name</color>**: CD47 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=961|961]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q08722|Q08722]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD47&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD47|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601028|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. {ECO:0000250, ECO:0000269|PubMed:11509594, ECO:0000269|PubMed:15383453, ECO:0000269|PubMed:7691831}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-set CD47|
|CD47|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|
|thrombospondin receptor activity|
|monocyte extravasation|
|regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|
|protein binding involved in heterotypic cell-cell adhesion|
|opsonization|
|regulation of Fc receptor mediated stimulatory signaling pathway|
|negative regulation of phagocytosis|
|cell-cell adhesion mediator activity|
|heterotypic cell-cell adhesion|
|cellular extravasation|
|cellular response to interleukin-12|
|mononuclear cell migration|
|response to interleukin-12|
|positive regulation of stress fiber assembly|
|regulation of interleukin-10 production|
|regulation of interleukin-12 production|
|regulation of nitric oxide biosynthetic process|
|positive regulation of actin filament bundle assembly|
|positive regulation of phagocytosis|
|tertiary granule membrane|
|regulation of stress fiber assembly|
|regulation of reactive oxygen species biosynthetic process|
|regulation of actomyosin structure organization|
|specific granule membrane|
|regulation of actin filament bundle assembly|
|integrin-mediated signaling pathway|
|regulation of phagocytosis|
|regulation of interferon-gamma production|
|negative regulation of immune effector process|
|myeloid leukocyte migration|
|positive regulation of inflammatory response|
|regulation of interleukin-6 production|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|cellular response to interferon-gamma|
|cellular response to interleukin-1|
|regulation of reactive oxygen species metabolic process|
|response to interferon-gamma|
|positive regulation of supramolecular fiber organization|
|response to interleukin-1|
|positive regulation of T cell activation|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of cytoskeleton organization|
|positive regulation of cell-cell adhesion|
|regulation of actin filament organization|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|phagocytosis|
|regulation of inflammatory response|
|extracellular matrix organization|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of neurotransmitter levels|
|positive regulation of lymphocyte activation|
|leukocyte migration|
|extracellular structure organization|
|regulation of actin filament-based process|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|negative regulation of immune system process|
|regulation of immune effector process|
|positive regulation of defense response|
|negative regulation of transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|cell-cell adhesion|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|myeloid leukocyte mediated immunity|
|positive regulation of cellular component biogenesis|
|myeloid cell activation involved in immune response|
|regulation of cytoskeleton organization|
|regulation of vesicle-mediated transport|
|myeloid leukocyte activation|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|cell surface|
|positive regulation of organelle organization|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulated exocytosis|
|regulation of defense response|
|leukocyte mediated immunity|
|innate immune response|
|exocytosis|
|positive regulation of cell population proliferation|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of transport|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|regulation of response to stress|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.2|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.79|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.78|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.72|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.76|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.8|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.96|
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.97|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|2.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7504
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD47 Expression in NALM6 Cells: 8.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>