======= CD55 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD55
  * **<color #00a2e8>Official Name</color>**: CD55 molecule (Cromer blood group)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1604|1604]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08174|P08174]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD55&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD55|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/125240|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014].  Sequence Note: This RefSeq record represents the CD55*001.1.1 allele. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sushi|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of CD4-positive, alpha-beta T cell proliferation|
|CD4-positive, alpha-beta T cell cytokine production|
|negative regulation of complement activation|
|T cell cytokine production|
|regulation of complement-dependent cytotoxicity|
|regulation of CD4-positive, alpha-beta T cell proliferation|
|negative regulation of humoral immune response|
|positive regulation of alpha-beta T cell proliferation|
|respiratory burst|
|cytokine production involved in immune response|
|regulation of lipopolysaccharide-mediated signaling pathway|
|regulation of alpha-beta T cell proliferation|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|T cell mediated immunity|
|positive regulation of alpha-beta T cell activation|
|regulation of CD4-positive, alpha-beta T cell activation|
|ficolin-1-rich granule membrane|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|virus receptor activity|
|transport vesicle|
|regulation of alpha-beta T cell activation|
|viral entry into host cell|
|positive regulation of T cell proliferation|
|secretory granule membrane|
|regulation of cell killing|
|anchored component of membrane|
|entry into host|
|entry into host cell|
|regulation of complement activation|
|negative regulation of immune effector process|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|regulation of humoral immune response|
|positive regulation of leukocyte proliferation|
|negative regulation of immune response|
|cytokine production|
|lipid binding|
|regulation of T cell proliferation|
|interaction with host|
|complement activation, classical pathway|
|humoral immune response mediated by circulating immunoglobulin|
|production of molecular mediator of immune response|
|complement activation|
|viral life cycle|
|positive regulation of T cell activation|
|immunoglobulin mediated immune response|
|regulation of lymphocyte proliferation|
|B cell mediated immunity|
|regulation of mononuclear cell proliferation|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|membrane raft|
|positive regulation of cell-cell adhesion|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of cytosolic calcium ion concentration|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|regulation of cytosolic calcium ion concentration|
|humoral immune response|
|positive regulation of lymphocyte activation|
|Golgi vesicle transport|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|cellular calcium ion homeostasis|
|negative regulation of immune system process|
|calcium ion homeostasis|
|regulation of immune effector process|
|cellular divalent inorganic cation homeostasis|
|neutrophil degranulation|
|divalent inorganic cation homeostasis|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|myeloid leukocyte mediated immunity|
|regulation of response to biotic stimulus|
|myeloid cell activation involved in immune response|
|cellular metal ion homeostasis|
|myeloid leukocyte activation|
|regulation of leukocyte activation|
|adaptive immune response|
|cell surface|
|Golgi membrane|
|leukocyte activation involved in immune response|
|metal ion homeostasis|
|cell activation involved in immune response|
|activation of immune response|
|cellular cation homeostasis|
|regulation of cell activation|
|cellular ion homeostasis|
|regulation of cell adhesion|
|viral process|
|regulated exocytosis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|leukocyte mediated immunity|
|innate immune response|
|regulation of multi-organism process|
|symbiotic process|
|ion homeostasis|
|exocytosis|
|interspecies interaction between organisms|
|positive regulation of immune response|
|cellular homeostasis|
|positive regulation of cell population proliferation|
|leukocyte activation|
|defense response to other organism|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|chemical homeostasis|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|intracellular transport|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|establishment of localization in cell|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16968
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD55 Expression in NALM6 Cells: 5.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>