======= CD72 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD72
  * **<color #00a2e8>Official Name</color>**: CD72 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=971|971]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21854|P21854]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD72&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD72|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107272|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in B-cell proliferation and differentiation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lectin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transmembrane signaling receptor activity|
|carbohydrate binding|
|signaling receptor binding|
|cell adhesion|
|biological adhesion|
|integral component of plasma membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.35|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-2.33|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-2.14|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.9|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.72|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.72|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.78|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.98|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2.05|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.07|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.12|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.33|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|2.47|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.68|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|3.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:ptpn6|PTPN6]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13816
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD72 Expression in NALM6 Cells: 5.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>