======= CD83 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD83
  * **<color #00a2e8>Official Name</color>**: CD83 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9308|9308]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01151|Q01151]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD83&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD83|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604534|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of interleukin-4 production|
|regulation of interleukin-4 production|
|positive regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of interleukin-2 production|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|positive regulation of interleukin-10 production|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of alpha-beta T cell differentiation|
|regulation of interleukin-10 production|
|regulation of interleukin-2 production|
|positive regulation of alpha-beta T cell activation|
|regulation of CD4-positive, alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|positive regulation of T cell differentiation|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|regulation of T cell differentiation|
|positive regulation of leukocyte differentiation|
|regulation of lymphocyte differentiation|
|positive regulation of hemopoiesis|
|positive regulation of T cell activation|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|humoral immune response|
|positive regulation of lymphocyte activation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of lymphocyte activation|
|regulation of leukocyte activation|
|regulation of cell activation|
|regulation of cell adhesion|
|regulation of cytokine production|
|response to organic cyclic compound|
|positive regulation of cell differentiation|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|defense response|
|positive regulation of developmental process|
|integral component of plasma membrane|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.464|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5326
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD83 Expression in NALM6 Cells: 3.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>