======= CD99L2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD99L2
  * **<color #00a2e8>Official Name</color>**: CD99 molecule like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83692|83692]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TCZ2|Q8TCZ2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD99L2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD99L2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300846|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cell-surface protein that is similar to CD99. A similar protein in mouse functions as an adhesion molecule during leukocyte extravasation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CD99L2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of T cell extravasation|
|regulation of T cell extravasation|
|diapedesis|
|T cell extravasation|
|positive regulation of neutrophil extravasation|
|regulation of neutrophil extravasation|
|positive regulation of cellular extravasation|
|T cell migration|
|regulation of cellular extravasation|
|positive regulation of neutrophil migration|
|positive regulation of T cell migration|
|regulation of neutrophil migration|
|positive regulation of lymphocyte migration|
|cellular extravasation|
|regulation of T cell migration|
|homotypic cell-cell adhesion|
|regulation of lymphocyte migration|
|lymphocyte migration|
|cell-cell adherens junction|
|positive regulation of leukocyte migration|
|regulation of leukocyte migration|
|leukocyte migration|
|focal adhesion|
|positive regulation of cell migration|
|cell-cell adhesion|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|cell surface|
|regulation of cell migration|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|localization of cell|
|cell motility|
|positive regulation of immune system process|
|locomotion|
|integral component of plasma membrane|
|movement of cell or subcellular component|
|regulation of immune system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.85|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.76|
|[[:results:exp302|35°C R06 exp302]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17286
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD99L2 Expression in NALM6 Cells: 4.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>