======= CDA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDA
  * **<color #00a2e8>Official Name</color>**: cytidine deaminase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=978|978]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P32320|P32320]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123920|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|dCMP cyt deam 2|
|dCMP cyt deam 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytosine metabolic process|
|nucleoside binding|
|pyrimidine nucleoside salvage|
|pyrimidine-containing compound salvage|
|cytidine metabolic process|
|cytidine catabolic process|
|cytidine deaminase activity|
|cytidine deamination|
|pyrimidine ribonucleoside catabolic process|
|pyrimidine ribonucleoside metabolic process|
|nucleoside salvage|
|pyrimidine nucleoside biosynthetic process|
|negative regulation of nucleotide metabolic process|
|pyrimidine nucleobase metabolic process|
|ribonucleoside catabolic process|
|pyrimidine nucleoside catabolic process|
|nucleoside catabolic process|
|cellular metabolic compound salvage|
|pyrimidine nucleoside metabolic process|
|nucleoside biosynthetic process|
|nucleobase metabolic process|
|glycosyl compound biosynthetic process|
|pyrimidine-containing compound catabolic process|
|glycosyl compound catabolic process|
|nucleobase-containing small molecule catabolic process|
|tertiary granule lumen|
|pyrimidine-containing compound biosynthetic process|
|ribonucleoside metabolic process|
|negative regulation of small molecule metabolic process|
|protein homotetramerization|
|pyrimidine-containing compound metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|nucleoside metabolic process|
|secretory granule lumen|
|regulation of nucleotide metabolic process|
|ficolin-1-rich granule lumen|
|glycosyl compound metabolic process|
|protein tetramerization|
|negative regulation of cell growth|
|carbohydrate derivative catabolic process|
|negative regulation of growth|
|protein homooligomerization|
|nucleobase-containing compound catabolic process|
|regulation of cell growth|
|regulation of small molecule metabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|myeloid cell activation involved in immune response|
|nucleobase-containing small molecule metabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|myeloid leukocyte activation|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of growth|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|zinc ion binding|
|protein homodimerization activity|
|leukocyte activation|
|secretion by cell|
|carbohydrate derivative metabolic process|
|export from cell|
|organonitrogen compound catabolic process|
|cell activation|
|immune effector process|
|nucleobase-containing compound biosynthetic process|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10194
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDA Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>