======= CDC25A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDC25A
  * **<color #00a2e8>Official Name</color>**: cell division cycle 25A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=993|993]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30304|P30304]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDC25A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDC25A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/116947|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rhodanese|
|M-inducer phosp|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of G2/MI transition of meiotic cell cycle|
|positive regulation of G2/MI transition of meiotic cell cycle|
|positive regulation of meiotic cell cycle phase transition|
|regulation of meiotic cell cycle phase transition|
|positive regulation of meiotic cell cycle|
|positive regulation of G2/M transition of mitotic cell cycle|
|positive regulation of cell cycle G2/M phase transition|
|phosphoprotein phosphatase activity|
|regulation of meiotic cell cycle|
|positive regulation of mitotic cell cycle phase transition|
|positive regulation of reproductive process|
|cellular response to UV|
|positive regulation of cell cycle phase transition|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|protein tyrosine phosphatase activity|
|chaperone binding|
|regulation of cyclin-dependent protein kinase activity|
|peptidyl-tyrosine dephosphorylation|
|cellular response to light stimulus|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|response to UV|
|positive regulation of mitotic cell cycle|
|regulation of reproductive process|
|cellular response to radiation|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|protein dephosphorylation|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|protein deubiquitination|
|positive regulation of cell cycle process|
|protein modification by small protein removal|
|response to light stimulus|
|dephosphorylation|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|response to radiation|
|regulation of cell cycle phase transition|
|protein kinase binding|
|cell division|
|regulation of protein serine/threonine kinase activity|
|cell population proliferation|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|regulation of cell cycle process|
|regulation of protein kinase activity|
|regulation of kinase activity|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|response to abiotic stimulus|
|regulation of cell cycle|
|proteolysis|
|cell cycle|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-2.27|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-2.14|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.98|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.87|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.84|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.81|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.72|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.7|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.7|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|1.71|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|1.72|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.83|
|[[:results:exp539|42°C R08 exp539]]|1.88|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.88|
|[[:results:exp285|GW501516 25μM R06 exp285]]|1.88|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cdk2|CDK2]]|0.433|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2831
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDC25A Expression in NALM6 Cells: 6.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>