======= CDC25C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDC25C
  * **<color #00a2e8>Official Name</color>**: cell division cycle 25C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=995|995]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30307|P30307]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDC25C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDC25C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/157680|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity. {ECO:0000269|PubMed:8119945}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rhodanese|
|M-inducer phosp|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of G2/MI transition of meiotic cell cycle|
|positive regulation of G2/MI transition of meiotic cell cycle|
|positive regulation of meiotic cell cycle phase transition|
|regulation of meiotic cell cycle phase transition|
|positive regulation of meiotic cell cycle|
|positive regulation of G2/M transition of mitotic cell cycle|
|positive regulation of cell cycle G2/M phase transition|
|WW domain binding|
|regulation of meiotic cell cycle|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|mitotic G1 DNA damage checkpoint|
|mitotic G1/S transition checkpoint|
|G1 DNA damage checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in cell cycle checkpoint|
|positive regulation of mitotic cell cycle phase transition|
|positive regulation of reproductive process|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|positive regulation of cell cycle phase transition|
|mitotic DNA damage checkpoint|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|protein tyrosine phosphatase activity|
|regulation of cyclin-dependent protein kinase activity|
|peptidyl-tyrosine dephosphorylation|
|negative regulation of G1/S transition of mitotic cell cycle|
|mitotic DNA integrity checkpoint|
|signal transduction in response to DNA damage|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|signal transduction by p53 class mediator|
|G2/M transition of mitotic cell cycle|
|DNA damage checkpoint|
|cell cycle G2/M phase transition|
|DNA integrity checkpoint|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|regulation of reproductive process|
|regulation of cell cycle G1/S phase transition|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|cell cycle checkpoint|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|protein dephosphorylation|
|negative regulation of cell cycle phase transition|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|dephosphorylation|
|negative regulation of cell cycle process|
|positive regulation of cell cycle|
|nuclear speck|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|protein kinase binding|
|cell division|
|regulation of protein serine/threonine kinase activity|
|spermatogenesis|
|cell population proliferation|
|male gamete generation|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|gamete generation|
|perinuclear region of cytoplasm|
|viral process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|symbiotic process|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|regulation of kinase activity|
|regulation of transferase activity|
|multi-organism reproductive process|
|cell cycle process|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|intracellular signal transduction|
|cellular response to stress|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.78|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8389
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDC25C Expression in NALM6 Cells: 3.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>