======= CDC42EP4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDC42EP4
  * **<color #00a2e8>Official Name</color>**: CDC42 effector protein 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23580|23580]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H3Q1|Q9H3Q1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDC42EP4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDC42EP4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605468|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PBD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of pseudopodium assembly|
|regulation of pseudopodium assembly|
|GTP-Rho binding|
|phagocytic vesicle|
|endomembrane system|
|Rho protein signal transduction|
|positive regulation of actin filament polymerization|
|positive regulation of plasma membrane bounded cell projection assembly|
|cell-cell adherens junction|
|positive regulation of protein polymerization|
|regulation of cell shape|
|microtubule cytoskeleton|
|cellular response to interferon-gamma|
|regulation of actin filament polymerization|
|response to interferon-gamma|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of supramolecular fiber organization|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|actin cytoskeleton|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|Ras protein signal transduction|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|small GTPase mediated signal transduction|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|regulation of protein complex assembly|
|regulation of cell morphogenesis|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|positive regulation of organelle organization|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|innate immune response|
|defense response to other organism|
|regulation of cellular component biogenesis|
|cellular response to cytokine stimulus|
|regulation of anatomical structure morphogenesis|
|response to cytokine|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|intracellular signal transduction|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.04|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.91|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.87|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.86|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.76|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8298
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDC42EP4 Expression in NALM6 Cells: 1.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>