======= CDC73 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDC73
  * **<color #00a2e8>Official Name</color>**: cell division cycle 73
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79577|79577]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6P1J9|Q6P1J9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDC73&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDC73|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607393|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors. {ECO:0000269|PubMed:15580289, ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15923622, ECO:0000269|PubMed:16630820, ECO:0000269|PubMed:16989776, ECO:0000269|PubMed:19136632, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CDC73|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|recruitment of 3-end processing factors to RNA polymerase II holoenzyme complex|
|Cdc73/Paf1 complex|
|histone H2B ubiquitination|
|positive regulation of mRNA 3-end processing|
|endodermal cell fate commitment|
|positive regulation of transcription elongation from RNA polymerase II promoter|
|regulation of mRNA 3-end processing|
|cell fate commitment involved in formation of primary germ layer|
|mRNA polyadenylation|
|negative regulation of fibroblast proliferation|
|beta-catenin-TCF complex assembly|
|regulation of transcription elongation from RNA polymerase II promoter|
|histone monoubiquitination|
|RNA polyadenylation|
|positive regulation of mRNA processing|
|positive regulation of DNA-templated transcription, elongation|
|RNA polymerase II complex binding|
|histone ubiquitination|
|endodermal cell differentiation|
|protein destabilization|
|positive regulation of cell cycle G1/S phase transition|
|endoderm formation|
|regulation of DNA-templated transcription, elongation|
|protein monoubiquitination|
|endoderm development|
|transcription elongation from RNA polymerase II promoter|
|negative regulation of myeloid cell differentiation|
|positive regulation of mRNA metabolic process|
|mRNA 3-end processing|
|regulation of fibroblast proliferation|
|DNA-templated transcription, elongation|
|positive regulation of cell cycle phase transition|
|negative regulation of G1/S transition of mitotic cell cycle|
|negative regulation of cell cycle G1/S phase transition|
|nuclear chromosome, telomeric region|
|formation of primary germ layer|
|negative regulation of epithelial cell proliferation|
|stem cell population maintenance|
|RNA 3-end processing|
|maintenance of cell number|
|negative regulation of hemopoiesis|
|regulation of mRNA processing|
|regulation of G1/S transition of mitotic cell cycle|
|gastrulation|
|regulation of cell cycle G1/S phase transition|
|positive regulation of Wnt signaling pathway|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|negative regulation of mitotic cell cycle phase transition|
|cellular response to biotic stimulus|
|regulation of myeloid cell differentiation|
|negative regulation of cell cycle phase transition|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|cell fate commitment|
|positive regulation of cell cycle process|
|regulation of protein stability|
|negative regulation of mitotic cell cycle|
|response to lipopolysaccharide|
|negative regulation of cell cycle process|
|response to molecule of bacterial origin|
|regulation of mRNA metabolic process|
|regulation of epithelial cell proliferation|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|histone modification|
|covalent chromatin modification|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|regulation of cell growth|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|negative regulation of immune system process|
|regulation of cell cycle phase transition|
|regulation of hemopoiesis|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|transcription by RNA polymerase II|
|cellular response to lipid|
|embryonic morphogenesis|
|negative regulation of cell cycle|
|regulation of mitotic cell cycle|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of growth|
|negative regulation of cell population proliferation|
|protein ubiquitination|
|response to bacterium|
|mRNA metabolic process|
|chromatin organization|
|negative regulation of cell differentiation|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|cellular protein-containing complex assembly|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|RNA processing|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|negative regulation of developmental process|
|embryo development|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|cellular response to oxygen-containing compound|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|cell-cell signaling|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.77|
|[[:results:exp135|MS023 7μM R03 exp135]]|-2.66|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-2.55|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.43|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-2.33|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-2.33|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.32|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-2.32|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-2.3|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.27|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-2.2|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.19|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-2.17|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.16|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.06|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.03|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.01|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.98|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.89|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.84|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.8|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.74|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.7|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.7|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.76|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.78|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.78|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.8|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.81|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.88|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.88|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.9|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|1.94|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.05|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|2.07|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|2.08|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|2.11|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|2.13|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|2.13|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|2.17|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|2.23|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.26|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.28|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|2.41|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|2.45|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.46|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.65|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ctr9|CTR9]]|0.581|
|[[:human genes:v:vasn|VASN]]|0.575|
|[[:human genes:p:psma6|PSMA6]]|0.562|
|[[:human genes:p:psmb4|PSMB4]]|0.56|
|[[:human genes:r:rbm39|RBM39]]|0.558|
|[[:human genes:c:ckap5|CKAP5]]|0.551|
|[[:human genes:r:rrn3|RRN3]]|0.547|
|[[:human genes:t:tceb3c|TCEB3C]]|0.542|
|[[:human genes:a:ahctf1|AHCTF1]]|0.54|
|[[:human genes:m:myo1h|MYO1H]]|0.54|
|[[:human genes:n:nup160|NUP160]]|0.534|
|[[:human genes:p:paf1|PAF1]]|0.533|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.527|
|[[:human genes:c:cope|COPE]]|0.526|
|[[:human genes:c:cgb2|CGB2]]|0.525|
|[[:human genes:p:psmd11|PSMD11]]|0.524|
|[[:human genes:h:hap1|HAP1]]|0.518|
|[[:human genes:r:rps12|RPS12]]|0.518|
|[[:human genes:c:cnot1|CNOT1]]|0.516|
|[[:human genes:p:psmd1|PSMD1]]|0.512|
|[[:human genes:p:psma7|PSMA7]]|0.512|
|[[:human genes:t:tfip11|TFIP11]]|0.512|
|[[:human genes:r:rps2|RPS2]]|0.51|
|[[:human genes:p:psmd3|PSMD3]]|0.51|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.51|
|[[:human genes:r:rpsa|RPSA]]|0.509|
|[[:human genes:c:cdc6|CDC6]]|0.509|
|[[:human genes:m:mt1e|MT1E]]|0.506|
|[[:human genes:p:psmc1|PSMC1]]|0.506|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.506|
|[[:human genes:c:cdca3|CDCA3]]|0.505|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.504|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.503|
|[[:human genes:d:dtl|DTL]]|0.503|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.502|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.502|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.501|
|[[:human genes:z:znf106|ZNF106]]|0.501|
|[[:human genes:p:pold1|POLD1]]|0.5|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.499|
|[[:human genes:p:psmc6|PSMC6]]|0.499|
|[[:human genes:c:c14orf93|C14orf93]]|0.498|
|[[:human genes:n:narfl|NARFL]]|0.498|
|[[:human genes:t:ticrr|TICRR]]|0.497|
|[[:human genes:r:rpa2|RPA2]]|0.497|
|[[:human genes:p:psmd14|PSMD14]]|0.496|
|[[:human genes:o:orc1|ORC1]]|0.496|
|[[:human genes:z:zfand5|ZFAND5]]|0.495|
|[[:human genes:s:snrpa1|SNRPA1]]|0.494|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.493|
|[[:human genes:c:col2a1|COL2A1]]|0.493|
|[[:human genes:o:orc6|ORC6]]|0.491|
|[[:human genes:p:pola2|POLA2]]|0.49|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.49|
|[[:human genes:p:psmb3|PSMB3]]|0.488|
|[[:human genes:s:s1pr4|S1PR4]]|0.488|
|[[:human genes:m:msh5|MSH5]]|0.487|
|[[:human genes:r:rbbp5|RBBP5]]|0.486|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.484|
|[[:human genes:t:trim52|TRIM52]]|0.482|
|[[:human genes:r:rps3|RPS3]]|0.48|
|[[:human genes:a:ankle2|ANKLE2]]|0.48|
|[[:human genes:z:znf830|ZNF830]]|0.479|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.477|
|[[:human genes:w:wdr61|WDR61]]|0.476|
|[[:human genes:p:psmc5|PSMC5]]|0.476|
|[[:human genes:a:akirin2|AKIRIN2]]|0.474|
|[[:human genes:c:cdk8|CDK8]]|0.473|
|[[:human genes:d:ddtl|DDTL]]|0.473|
|[[:human genes:r:rps28|RPS28]]|0.473|
|[[:human genes:c:copg1|COPG1]]|0.472|
|[[:human genes:r:rpl14|RPL14]]|0.47|
|[[:human genes:n:ndc80|NDC80]]|0.469|
|[[:human genes:r:rps9|RPS9]]|0.469|
|[[:human genes:c:chd4|CHD4]]|0.467|
|[[:human genes:k:kctd17|KCTD17]]|0.467|
|[[:human genes:p:psmb1|PSMB1]]|0.467|
|[[:human genes:r:rpl35|RPL35]]|0.467|
|[[:human genes:n:nupl1|NUPL1]]|0.467|
|[[:human genes:g:gar1|GAR1]]|0.466|
|[[:human genes:i:ints6|INTS6]]|0.465|
|[[:human genes:a:aqr|AQR]]|0.464|
|[[:human genes:s:scaf1|SCAF1]]|0.463|
|[[:human genes:n:nufip2|NUFIP2]]|0.462|
|[[:human genes:i:ints5|INTS5]]|0.462|
|[[:human genes:a:aaas|AAAS]]|0.461|
|[[:human genes:t:tpx2|TPX2]]|0.46|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.459|
|[[:human genes:z:znf148|ZNF148]]|0.459|
|[[:human genes:r:rpl6|RPL6]]|0.457|
|[[:human genes:p:psmb2|PSMB2]]|0.457|
|[[:human genes:s:snrnp70|SNRNP70]]|0.455|
|[[:human genes:w:wdr87|WDR87]]|0.455|
|[[:human genes:s:sf3a1|SF3A1]]|0.455|
|[[:human genes:p:pan3|PAN3]]|0.454|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.454|
|[[:human genes:r:rps5|RPS5]]|0.453|
|[[:human genes:s:supt6h|SUPT6H]]|0.453|
|[[:human genes:s:sec13|SEC13]]|0.452|
|[[:human genes:c:cwc22|CWC22]]|0.451|
|[[:human genes:r:rps3a|RPS3A]]|0.449|
|[[:human genes:t:twistnb|TWISTNB]]|0.449|
|[[:human genes:g:golga8o|GOLGA8O]]|0.448|
|[[:human genes:p:pwp2|PWP2]]|0.447|
|[[:human genes:s:smg7|SMG7]]|0.447|
|[[:human genes:c:cactin|CACTIN]]|0.446|
|[[:human genes:l:lrr1|LRR1]]|0.446|
|[[:human genes:c:cep192|CEP192]]|0.446|
|[[:human genes:t:terf2|TERF2]]|0.446|
|[[:human genes:i:ilf2|ILF2]]|0.446|
|[[:human genes:s:ssh2|SSH2]]|0.446|
|[[:human genes:d:dock6|DOCK6]]|0.445|
|[[:human genes:f:fancm|FANCM]]|0.444|
|[[:human genes:f:fam160a1|FAM160A1]]|0.443|
|[[:human genes:s:supt5h|SUPT5H]]|0.443|
|[[:human genes:p:ppm1d|PPM1D]]|0.442|
|[[:human genes:a:acsf2|ACSF2]]|0.442|
|[[:human genes:s:sf3a3|SF3A3]]|0.441|
|[[:human genes:d:dido1|DIDO1]]|0.441|
|[[:human genes:r:rfc1|RFC1]]|0.441|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.441|
|[[:human genes:a:arcn1|ARCN1]]|0.441|
|[[:human genes:r:rrp15|RRP15]]|0.44|
|[[:human genes:n:nbpf10|NBPF10]]|0.44|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.44|
|[[:human genes:p:psmd2|PSMD2]]|0.44|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.44|
|[[:human genes:r:rps14|RPS14]]|0.439|
|[[:human genes:e:exosc3|EXOSC3]]|0.439|
|[[:human genes:s:smg1|SMG1]]|0.438|
|[[:human genes:c:cmya5|CMYA5]]|0.438|
|[[:human genes:c:crnkl1|CRNKL1]]|0.438|
|[[:human genes:p:ppfia4|PPFIA4]]|0.437|
|[[:human genes:f:fam86b2|FAM86B2]]|0.437|
|[[:human genes:g:gon4l|GON4L]]|0.437|
|[[:human genes:c:copa|COPA]]|0.437|
|[[:human genes:c:cbwd6|CBWD6]]|0.437|
|[[:human genes:n:npipb8|NPIPB8]]|0.436|
|[[:human genes:c:cbwd5|CBWD5]]|0.436|
|[[:human genes:s:srsf1|SRSF1]]|0.436|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.436|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.435|
|[[:human genes:x:xylt2|XYLT2]]|0.434|
|[[:human genes:a:atxn1|ATXN1]]|0.434|
|[[:human genes:p:polr1a|POLR1A]]|0.434|
|[[:human genes:p:pole|POLE]]|0.433|
|[[:human genes:r:rpl38|RPL38]]|0.433|
|[[:human genes:b:bod1l1|BOD1L1]]|0.433|
|[[:human genes:e:exosc5|EXOSC5]]|0.431|
|[[:human genes:p:psmd7|PSMD7]]|0.431|
|[[:human genes:b:bms1|BMS1]]|0.43|
|[[:human genes:p:prpf3|PRPF3]]|0.43|
|[[:human genes:s:sf3b2|SF3B2]]|0.43|
|[[:human genes:r:rplp1|RPLP1]]|0.43|
|[[:human genes:c:chmp2a|CHMP2A]]|0.43|
|[[:human genes:c:cenpp|CENPP]]|0.429|
|[[:human genes:p:psap|PSAP]]|0.429|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.429|
|[[:human genes:t:tagln|TAGLN]]|0.427|
|[[:human genes:n:ncapg|NCAPG]]|0.427|
|[[:human genes:g:golga8h|GOLGA8H]]|0.427|
|[[:human genes:c:chaf1a|CHAF1A]]|0.426|
|[[:human genes:r:rad21|RAD21]]|0.426|
|[[:human genes:d:ddx51|DDX51]]|0.426|
|[[:human genes:t:tuba8|TUBA8]]|0.425|
|[[:human genes:m:madcam1|MADCAM1]]|0.424|
|[[:human genes:e:exosc9|EXOSC9]]|0.424|
|[[:human genes:c:cdt1|CDT1]]|0.424|
|[[:human genes:c:ccna2|CCNA2]]|0.423|
|[[:human genes:r:rnf113a|RNF113A]]|0.423|
|[[:human genes:i:iscu|ISCU]]|0.423|
|[[:human genes:s:syt9|SYT9]]|0.423|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.423|
|[[:human genes:r:rpl8|RPL8]]|0.422|
|[[:human genes:n:nup85|NUP85]]|0.422|
|[[:human genes:r:rprd2|RPRD2]]|0.421|
|[[:human genes:w:wdr75|WDR75]]|0.421|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.42|
|[[:human genes:c:cbwd3|CBWD3]]|0.42|
|[[:human genes:k:krt78|KRT78]]|0.419|
|[[:human genes:i:ints1|INTS1]]|0.419|
|[[:human genes:p:plk1|PLK1]]|0.418|
|[[:human genes:d:ddx56|DDX56]]|0.418|
|[[:human genes:n:nop16|NOP16]]|0.417|
|[[:human genes:r:rpl34|RPL34]]|0.417|
|[[:human genes:p:psmc2|PSMC2]]|0.415|
|[[:human genes:p:pitpnm3|PITPNM3]]|0.415|
|[[:human genes:r:rad51|RAD51]]|0.415|
|[[:human genes:t:taf15|TAF15]]|0.414|
|[[:human genes:t:tsg101|TSG101]]|0.414|
|[[:human genes:t:topbp1|TOPBP1]]|0.414|
|[[:human genes:h:hist1h2aj|HIST1H2AJ]]|0.414|
|[[:human genes:n:nuf2|NUF2]]|0.414|
|[[:human genes:n:napa|NAPA]]|0.414|
|[[:human genes:i:ik|IK]]|0.413|
|[[:human genes:p:ppan|PPAN]]|0.413|
|[[:human genes:p:prkcz|PRKCZ]]|0.413|
|[[:human genes:m:mdm2|MDM2]]|0.413|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.412|
|[[:human genes:p:psma1|PSMA1]]|0.412|
|[[:human genes:n:nol10|NOL10]]|0.412|
|[[:human genes:o:or10g3|OR10G3]]|0.412|
|[[:human genes:r:rilpl1|RILPL1]]|0.411|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.411|
|[[:human genes:s:slc4a1|SLC4A1]]|0.411|
|[[:human genes:p:pan2|PAN2]]|0.411|
|[[:human genes:p:psmc4|PSMC4]]|0.411|
|[[:human genes:g:golga8j|GOLGA8J]]|0.408|
|[[:human genes:n:ndc1|NDC1]]|0.408|
|[[:human genes:e:eif4a3|EIF4A3]]|0.408|
|[[:human genes:p:prpf19|PRPF19]]|0.407|
|[[:human genes:g:gpx4|GPX4]]|0.407|
|[[:human genes:u:ubap1|UBAP1]]|0.406|
|[[:human genes:n:nfatc4|NFATC4]]|0.406|
|[[:human genes:c:ccdc94|CCDC94]]|0.404|
|[[:human genes:n:nup133|NUP133]]|0.404|
|[[:human genes:p:psmc3|PSMC3]]|0.403|
|[[:human genes:m:mki67ip|MKI67IP]]|0.403|
|[[:human genes:n:nip7|NIP7]]|0.402|
|[[:human genes:i:igfn1|IGFN1]]|0.402|
|[[:human genes:e:eif3g|EIF3G]]|0.402|
|[[:human genes:t:tbc1d7|TBC1D7]]|0.402|
|[[:human genes:c:cyb561a3|CYB561A3]]|0.402|
|[[:human genes:p:polr2f|POLR2F]]|0.401|
|[[:human genes:f:fam20a|FAM20A]]|0.401|
|[[:human genes:e:elmod3|ELMOD3]]|0.4|
|[[:human genes:w:wdr46|WDR46]]|0.4|
|[[:human genes:p:plk4|PLK4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 281/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|10/28|
|blood|13/28|
|bone|16/25|
|breast|11/33|
|central nervous system|24/56|
|cervix|0/4|
|colorectal|6/17|
|esophagus|1/13|
|fibroblast|1/1|
|gastric|6/15|
|kidney|8/21|
|liver|4/20|
|lung|25/75|
|lymphocyte|7/14|
|ovary|9/26|
|pancreas|4/24|
|peripheral nervous system|7/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|9/24|
|soft tissue|4/7|
|thyroid|1/2|
|upper aerodigestive|13/22|
|urinary tract|12/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 749
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDC73 Expression in NALM6 Cells: 5.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>