======= CDCA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDCA3
  * **<color #00a2e8>Official Name</color>**: cell division cycle associated 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83461|83461]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99618|Q99618]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDCA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDCA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607749|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell-cell adherens junction|
|cell division|
|protein ubiquitination|
|protein modification by small protein conjugation|
|protein modification by small protein conjugation or removal|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.94|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.81|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.75|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.86|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.88|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.97|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.573|
|[[:human genes:t:tceb3c|TCEB3C]]|0.56|
|[[:human genes:t:ticrr|TICRR]]|0.546|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.542|
|[[:human genes:p:psmd3|PSMD3]]|0.542|
|[[:human genes:i:ik|IK]]|0.532|
|[[:human genes:v:vasn|VASN]]|0.53|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.526|
|[[:human genes:n:nupl1|NUPL1]]|0.524|
|[[:human genes:p:pan2|PAN2]]|0.522|
|[[:human genes:c:cope|COPE]]|0.521|
|[[:human genes:p:psmd7|PSMD7]]|0.519|
|[[:human genes:p:psmb4|PSMB4]]|0.511|
|[[:human genes:c:ccna2|CCNA2]]|0.507|
|[[:human genes:t:tfip11|TFIP11]]|0.507|
|[[:human genes:s:ssh2|SSH2]]|0.507|
|[[:human genes:c:cdc73|CDC73]]|0.505|
|[[:human genes:s:supt6h|SUPT6H]]|0.501|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.501|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.498|
|[[:human genes:p:pole|POLE]]|0.496|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.491|
|[[:human genes:d:ddtl|DDTL]]|0.491|
|[[:human genes:p:pola2|POLA2]]|0.491|
|[[:human genes:s:smg7|SMG7]]|0.49|
|[[:human genes:c:c14orf93|C14orf93]]|0.488|
|[[:human genes:p:paf1|PAF1]]|0.487|
|[[:human genes:c:ckap5|CKAP5]]|0.487|
|[[:human genes:k:krt78|KRT78]]|0.484|
|[[:human genes:m:msh5|MSH5]]|0.484|
|[[:human genes:p:pan3|PAN3]]|0.483|
|[[:human genes:z:zfand5|ZFAND5]]|0.481|
|[[:human genes:c:copg1|COPG1]]|0.48|
|[[:human genes:c:chd4|CHD4]]|0.48|
|[[:human genes:r:rplp1|RPLP1]]|0.477|
|[[:human genes:h:hivep3|HIVEP3]]|0.477|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.477|
|[[:human genes:a:akirin2|AKIRIN2]]|0.475|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.475|
|[[:human genes:a:aaas|AAAS]]|0.474|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.472|
|[[:human genes:m:mat2a|MAT2A]]|0.471|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.47|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.47|
|[[:human genes:p:psma6|PSMA6]]|0.47|
|[[:human genes:s:slc4a1|SLC4A1]]|0.469|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.469|
|[[:human genes:o:orc1|ORC1]]|0.468|
|[[:human genes:d:dtl|DTL]]|0.468|
|[[:human genes:r:rps12|RPS12]]|0.467|
|[[:human genes:e:eif4a3|EIF4A3]]|0.467|
|[[:human genes:s:snrpa1|SNRPA1]]|0.467|
|[[:human genes:p:psmd1|PSMD1]]|0.467|
|[[:human genes:n:nhp2l1|NHP2L1]]|0.466|
|[[:human genes:n:nol12|NOL12]]|0.466|
|[[:human genes:c:copb1|COPB1]]|0.464|
|[[:human genes:n:nup85|NUP85]]|0.463|
|[[:human genes:n:narfl|NARFL]]|0.463|
|[[:human genes:n:nup153|NUP153]]|0.461|
|[[:human genes:m:mdm2|MDM2]]|0.461|
|[[:human genes:t:timeless|TIMELESS]]|0.46|
|[[:human genes:o:orc6|ORC6]]|0.458|
|[[:human genes:s:smg1|SMG1]]|0.457|
|[[:human genes:l:lrr1|LRR1]]|0.457|
|[[:human genes:c:cnot1|CNOT1]]|0.455|
|[[:human genes:r:rps2|RPS2]]|0.454|
|[[:human genes:m:mt1e|MT1E]]|0.453|
|[[:human genes:z:znf106|ZNF106]]|0.453|
|[[:human genes:r:rbm8a|RBM8A]]|0.453|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.452|
|[[:human genes:n:nbpf16|NBPF16]]|0.452|
|[[:human genes:m:myh2|MYH2]]|0.452|
|[[:human genes:n:nup43|NUP43]]|0.449|
|[[:human genes:z:znf830|ZNF830]]|0.448|
|[[:human genes:w:wdr43|WDR43]]|0.448|
|[[:human genes:n:ndc1|NDC1]]|0.447|
|[[:human genes:a:aqr|AQR]]|0.447|
|[[:human genes:t:tspy8|TSPY8]]|0.446|
|[[:human genes:p:psma1|PSMA1]]|0.446|
|[[:human genes:r:rbm39|RBM39]]|0.446|
|[[:human genes:s:supt5h|SUPT5H]]|0.446|
|[[:human genes:c:cbwd3|CBWD3]]|0.445|
|[[:human genes:s:srfbp1|SRFBP1]]|0.445|
|[[:human genes:n:npipb5|NPIPB5]]|0.443|
|[[:human genes:r:rpl6|RPL6]]|0.443|
|[[:human genes:p:psmd11|PSMD11]]|0.442|
|[[:human genes:t:tyms|TYMS]]|0.441|
|[[:human genes:h:hap1|HAP1]]|0.44|
|[[:human genes:c:cln6|CLN6]]|0.44|
|[[:human genes:r:rps3|RPS3]]|0.439|
|[[:human genes:c:cbwd5|CBWD5]]|0.438|
|[[:human genes:p:pwp2|PWP2]]|0.437|
|[[:human genes:c:chaf1a|CHAF1A]]|0.437|
|[[:human genes:v:vps28|VPS28]]|0.436|
|[[:human genes:p:plekha4|PLEKHA4]]|0.436|
|[[:human genes:c:casc5|CASC5]]|0.436|
|[[:human genes:p:pold1|POLD1]]|0.436|
|[[:human genes:p:psmc6|PSMC6]]|0.436|
|[[:human genes:t:tsg101|TSG101]]|0.436|
|[[:human genes:p:psmb3|PSMB3]]|0.435|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.435|
|[[:human genes:w:wdr87|WDR87]]|0.434|
|[[:human genes:s:stil|STIL]]|0.434|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.433|
|[[:human genes:k:kctd17|KCTD17]]|0.432|
|[[:human genes:u:upf1|UPF1]]|0.432|
|[[:human genes:a:atp13a1|ATP13A1]]|0.432|
|[[:human genes:c:cep192|CEP192]]|0.432|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.431|
|[[:human genes:g:gon4l|GON4L]]|0.431|
|[[:human genes:p:polr2j|POLR2J]]|0.431|
|[[:human genes:p:ppfia4|PPFIA4]]|0.431|
|[[:human genes:o:ogfr|OGFR]]|0.431|
|[[:human genes:p:ppie|PPIE]]|0.43|
|[[:human genes:s:sfpq|SFPQ]]|0.43|
|[[:human genes:n:nup205|NUP205]]|0.43|
|[[:human genes:p:psmc4|PSMC4]]|0.429|
|[[:human genes:c:cdc6|CDC6]]|0.428|
|[[:human genes:o:osbp|OSBP]]|0.428|
|[[:human genes:n:napa|NAPA]]|0.427|
|[[:human genes:d:dock6|DOCK6]]|0.427|
|[[:human genes:a:atp6ap2|ATP6AP2]]|0.426|
|[[:human genes:i:igfn1|IGFN1]]|0.426|
|[[:human genes:a:aamp|AAMP]]|0.426|
|[[:human genes:c:copa|COPA]]|0.426|
|[[:human genes:d:disp2|DISP2]]|0.426|
|[[:human genes:r:rad21|RAD21]]|0.426|
|[[:human genes:p:psmc1|PSMC1]]|0.425|
|[[:human genes:x:xylt2|XYLT2]]|0.425|
|[[:human genes:u:uqcrh|UQCRH]]|0.424|
|[[:human genes:r:rpl26|RPL26]]|0.424|
|[[:human genes:a:ahctf1|AHCTF1]]|0.424|
|[[:human genes:k:kpnb1|KPNB1]]|0.423|
|[[:human genes:p:psmb2|PSMB2]]|0.423|
|[[:human genes:s:slc7a6os|SLC7A6OS]]|0.421|
|[[:human genes:u:ubap1|UBAP1]]|0.42|
|[[:human genes:r:rpsa|RPSA]]|0.42|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.42|
|[[:human genes:g:golga8o|GOLGA8O]]|0.42|
|[[:human genes:c:ctr9|CTR9]]|0.42|
|[[:human genes:r:rrp15|RRP15]]|0.419|
|[[:human genes:g:gosr2|GOSR2]]|0.418|
|[[:human genes:s:s1pr4|S1PR4]]|0.418|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.418|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.418|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.418|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.418|
|[[:human genes:r:rrn3|RRN3]]|0.418|
|[[:human genes:n:nol10|NOL10]]|0.417|
|[[:human genes:n:nup214|NUP214]]|0.417|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.417|
|[[:human genes:c:col2a1|COL2A1]]|0.417|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.415|
|[[:human genes:s:specc1l|SPECC1L]]|0.415|
|[[:human genes:r:rps7|RPS7]]|0.415|
|[[:human genes:r:rps9|RPS9]]|0.413|
|[[:human genes:p:pno1|PNO1]]|0.413|
|[[:human genes:r:rangap1|RANGAP1]]|0.413|
|[[:human genes:e:exd1|EXD1]]|0.412|
|[[:human genes:c:cdca5|CDCA5]]|0.412|
|[[:human genes:s:sec13|SEC13]]|0.412|
|[[:human genes:n:nup54|NUP54]]|0.412|
|[[:human genes:e:egr2|EGR2]]|0.412|
|[[:human genes:c:cacna1a|CACNA1A]]|0.411|
|[[:human genes:m:mms22l|MMS22L]]|0.41|
|[[:human genes:m:med29|MED29]]|0.41|
|[[:human genes:a:aatf|AATF]]|0.409|
|[[:human genes:p:pdcd11|PDCD11]]|0.409|
|[[:human genes:l:lad1|LAD1]]|0.409|
|[[:human genes:c:cbwd6|CBWD6]]|0.408|
|[[:human genes:p:psmd2|PSMD2]]|0.408|
|[[:human genes:p:psmb1|PSMB1]]|0.407|
|[[:human genes:t:traip|TRAIP]]|0.407|
|[[:human genes:s:sf3a3|SF3A3]]|0.407|
|[[:human genes:i:itga2b|ITGA2B]]|0.406|
|[[:human genes:p:plk4|PLK4]]|0.406|
|[[:human genes:c:chst3|CHST3]]|0.405|
|[[:human genes:r:rrp1|RRP1]]|0.405|
|[[:human genes:a:agap5|AGAP5]]|0.404|
|[[:human genes:f:fam160a1|FAM160A1]]|0.404|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.403|
|[[:human genes:r:rpl35|RPL35]]|0.403|
|[[:human genes:p:psmc2|PSMC2]]|0.403|
|[[:human genes:r:ranbp2|RANBP2]]|0.403|
|[[:human genes:r:rps3a|RPS3A]]|0.403|
|[[:human genes:r:rrp7a|RRP7A]]|0.402|
|[[:human genes:p:polr1a|POLR1A]]|0.402|
|[[:human genes:c:cdh24|CDH24]]|0.402|
|[[:human genes:n:nup155|NUP155]]|0.401|
|[[:human genes:p:ppm1d|PPM1D]]|0.401|
|[[:human genes:s:smc3|SMC3]]|0.401|
|[[:human genes:r:rpl8|RPL8]]|0.401|
|[[:human genes:r:rpl14|RPL14]]|0.401|
|[[:human genes:r:riok2|RIOK2]]|0.401|
|[[:human genes:p:polr2a|POLR2A]]|0.401|
|[[:human genes:e:exosc6|EXOSC6]]|0.401|
|[[:human genes:r:rbbp5|RBBP5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 719
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDCA3 Expression in NALM6 Cells: 6.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>