======= CDCA8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDCA8
  * **<color #00a2e8>Official Name</color>**: cell division cycle associated 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55143|55143]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q53HL2|Q53HL2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDCA8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDCA8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609977|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment- error-correction and chromosome alignment. {ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:15260989, ECO:0000269|PubMed:16571674, ECO:0000269|PubMed:18243099}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nbl1 Borealin N|
|Borealin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chromosome passenger complex|
|chromocenter|
|spindle midzone|
|mitotic metaphase plate congression|
|chromosome, centromeric region|
|metaphase plate congression|
|intercellular bridge|
|establishment of chromosome localization|
|chromosome localization|
|mitotic sister chromatid segregation|
|sister chromatid segregation|
|mitotic nuclear division|
|midbody|
|nuclear chromosome segregation|
|chromosome segregation|
|nuclear division|
|organelle fission|
|establishment of organelle localization|
|cell division|
|organelle localization|
|protein-containing complex|
|mitotic cell cycle process|
|mitotic cell cycle|
|nucleolus|
|cell cycle process|
|chromosome organization|
|cell cycle|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-3.05|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.59|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.32|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.29|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.23|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-2.14|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.08|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.94|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.76|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.72|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.71|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.7|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.98|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.99|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.29|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.32|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|2.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:aurkb|AURKB]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 719/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|30/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 569
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDCA8 Expression in NALM6 Cells: 6.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>