======= CDH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDH1
  * **<color #00a2e8>Official Name</color>**: cadherin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=999|999]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P12830|P12830]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/192090|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:16417575}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cadherin pro|
|Cadherin|
|Cadherin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of protein catabolic process at postsynapse, modulating synaptic transmission|
|response to indole-3-methanol|
|cellular response to indole-3-methanol|
|flotillin complex|
|entry of bacterium into host cell|
|gamma-catenin binding|
|cellular response to lithium ion|
|postsynaptic modulation of chemical synaptic transmission|
|GTPase activating protein binding|
|apical junction complex|
|ankyrin binding|
|response to lithium ion|
|cell-cell adhesion mediated by cadherin|
|catenin complex|
|positive regulation of protein import into nucleus|
|positive regulation of protein import|
|pituitary gland development|
|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|
|cortical actin cytoskeleton|
|cytoplasmic side of plasma membrane|
|regulation of protein import into nucleus|
|lateral plasma membrane|
|regulation of protein import|
|cell adhesion molecule binding|
|positive regulation of nucleocytoplasmic transport|
|positive regulation of protein localization to nucleus|
|diencephalon development|
|cytoskeletal protein binding|
|beta-catenin binding|
|postsynapse|
|adherens junction organization|
|cellular response to alcohol|
|synapse assembly|
|response to antineoplastic agent|
|entry into host cell|
|entry into host|
|cell-cell adherens junction|
|cell-cell junction assembly|
|regulation of nucleocytoplasmic transport|
|regulation of protein localization to nucleus|
|endocrine system development|
|cell-cell junction organization|
|positive regulation of intracellular protein transport|
|interaction with host|
|cell junction assembly|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|trans-Golgi network|
|negative regulation of cell-cell adhesion|
|lamellipodium|
|protein localization to plasma membrane|
|cellular response to metal ion|
|positive regulation of intracellular transport|
|cell junction organization|
|actin cytoskeleton|
|cellular response to inorganic substance|
|protein localization to cell periphery|
|regulation of intracellular protein transport|
|response to alcohol|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|negative regulation of cell migration|
|endosome|
|synapse organization|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|cadherin binding|
|negative regulation of locomotion|
|positive regulation of cellular protein localization|
|extracellular matrix organization|
|glutamatergic synapse|
|regulation of intracellular transport|
|response to metal ion|
|regulation of protein catabolic process|
|extracellular structure organization|
|forebrain development|
|regulation of cell-cell adhesion|
|cellular response to drug|
|gland development|
|positive regulation of protein transport|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of establishment of protein localization|
|protein localization to membrane|
|cell-cell adhesion|
|response to toxic substance|
|response to inorganic substance|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|cell junction|
|cellular response to organonitrogen compound|
|cell surface|
|cellular response to nitrogen compound|
|neuron projection development|
|regulation of cell adhesion|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|calcium ion binding|
|cell morphogenesis|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|head development|
|symbiotic process|
|neuron development|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|regulation of cell migration|
|protein homodimerization activity|
|regulation of cell motility|
|regulation of cellular localization|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|regulation of catabolic process|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of RNA metabolic process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-1.93|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.8|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.81|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7342
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDH1 Expression in NALM6 Cells: 2.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>