======= CDH3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDH3
  * **<color #00a2e8>Official Name</color>**: cadherin 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1001|1001]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22223|P22223]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDH3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDH3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114021|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). [provided by RefSeq, Nov 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cadherin C|
|Cadherin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of monophenol monooxygenase activity|
|positive regulation of melanosome transport|
|negative regulation of timing of catagen|
|regulation of monophenol monooxygenase activity|
|regulation of hair cycle by canonical Wnt signaling pathway|
|regulation of melanosome transport|
|negative regulation of hair follicle maturation|
|negative regulation of transforming growth factor beta2 production|
|regulation of timing of catagen|
|negative regulation of hair follicle development|
|negative regulation of hair cycle|
|positive regulation of melanin biosynthetic process|
|positive regulation of secondary metabolite biosynthetic process|
|regulation of transforming growth factor beta2 production|
|negative regulation of transforming growth factor beta production|
|regulation of hair follicle maturation|
|regulation of melanin biosynthetic process|
|regulation of secondary metabolite biosynthetic process|
|positive regulation of keratinocyte proliferation|
|positive regulation of insulin-like growth factor receptor signaling pathway|
|regulation of secondary metabolic process|
|negative regulation of epidermis development|
|regulation of hair follicle development|
|regulation of insulin-like growth factor receptor signaling pathway|
|cell-cell adhesion mediated by cadherin|
|positive regulation of monooxygenase activity|
|regulation of hair cycle|
|catenin complex|
|regulation of keratinocyte proliferation|
|regulation of transforming growth factor beta production|
|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|
|positive regulation of oxidoreductase activity|
|regulation of monooxygenase activity|
|molting cycle process|
|retina homeostasis|
|hair cycle process|
|cytoskeletal protein binding|
|adherens junction organization|
|regulation of epidermis development|
|canonical Wnt signaling pathway|
|hair cycle|
|molting cycle|
|regulation of oxidoreductase activity|
|cell-cell adherens junction|
|cell-cell junction assembly|
|cell-cell junction organization|
|positive regulation of canonical Wnt signaling pathway|
|cell junction assembly|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|positive regulation of Wnt signaling pathway|
|positive regulation of epithelial cell proliferation|
|tissue homeostasis|
|cell junction organization|
|visual perception|
|sensory perception of light stimulus|
|keratinization|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|negative regulation of cytokine production|
|keratinocyte differentiation|
|regulation of canonical Wnt signaling pathway|
|cadherin binding|
|epidermal cell differentiation|
|multicellular organismal homeostasis|
|regulation of epithelial cell proliferation|
|anatomical structure homeostasis|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|skin development|
|epidermis development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|wound healing|
|cell-cell adhesion|
|response to wounding|
|cell surface|
|epithelial cell differentiation|
|regulation of cytokine production|
|calcium ion binding|
|cell morphogenesis|
|molecular function|
|cellular component morphogenesis|
|protein homodimerization activity|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|sensory perception|
|positive regulation of transport|
|response to drug|
|epithelium development|
|cell-cell signaling|
|negative regulation of multicellular organismal process|
|nervous system process|
|positive regulation of catalytic activity|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|tissue development|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golph3|GOLPH3]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4585
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDH3 Expression in NALM6 Cells: 1.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>