======= CDK5R1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDK5R1
  * **<color #00a2e8>Official Name</color>**: cyclin dependent kinase 5 regulatory subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8851|8851]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15078|Q15078]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDK5R1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDK5R1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603460|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269|PubMed:24235147}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CDK5 activator|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|superior olivary nucleus maturation|
|superior olivary nucleus development|
|protein kinase 5 complex|
|pons maturation|
|serine phosphorylation of STAT protein|
|contractile fiber|
|hindbrain maturation|
|central nervous system maturation|
|cyclin-dependent protein serine/threonine kinase activator activity|
|pons development|
|layer formation in cerebral cortex|
|neuron cell-cell adhesion|
|G protein-coupled acetylcholine receptor signaling pathway|
|cerebral cortex radial glia guided migration|
|telencephalon glial cell migration|
|axonal fasciculation|
|neuron projection fasciculation|
|ionotropic glutamate receptor signaling pathway|
|protein kinase activator activity|
|ephrin receptor binding|
|protein serine/threonine kinase activator activity|
|cerebral cortex radially oriented cell migration|
|positive regulation of microtubule polymerization|
|acetylcholine receptor signaling pathway|
|positive regulation of protein targeting to membrane|
|positive regulation of cyclin-dependent protein serine/threonine kinase activity|
|cellular response to acetylcholine|
|response to acetylcholine|
|ionotropic glutamate receptor binding|
|positive regulation of microtubule polymerization or depolymerization|
|positive regulation of cyclin-dependent protein kinase activity|
|glial cell migration|
|regulation of protein targeting to membrane|
|beta-tubulin binding|
|alpha-tubulin binding|
|postsynaptic signal transduction|
|negative regulation of axon extension|
|cerebral cortex cell migration|
|regulation of dendritic spine morphogenesis|
|glutamate receptor signaling pathway|
|neuron recognition|
|regulation of microtubule polymerization|
|positive regulation of neuron apoptotic process|
|telencephalon cell migration|
|forebrain cell migration|
|neural nucleus development|
|negative regulation of axonogenesis|
|regulation of dendritic spine development|
|neuromuscular junction|
|positive regulation of cell cycle arrest|
|regulation of microtubule polymerization or depolymerization|
|kinase activity|
|hippocampus development|
|regulation of protein targeting|
|peptidyl-threonine phosphorylation|
|ephrin receptor signaling pathway|
|peptidyl-threonine modification|
|regulation of dendrite morphogenesis|
|positive regulation of neuron death|
|signal transduction involved in cellular response to ammonium ion|
|presynapse|
|regulation of axon extension|
|regulation of postsynapse organization|
|negative regulation of cell morphogenesis involved in differentiation|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|protease binding|
|cerebellum development|
|regulation of cyclin-dependent protein kinase activity|
|negative regulation of developmental growth|
|regulation of cell cycle arrest|
|limbic system development|
|regulation of extent of cell growth|
|metencephalon development|
|regulation of synaptic vesicle cycle|
|cerebral cortex development|
|neuron migration|
|positive regulation of protein localization to membrane|
|positive regulation of protein polymerization|
|growth cone|
|regulation of receptor signaling pathway via JAK-STAT|
|cellular response to ammonium ion|
|regulation of receptor signaling pathway via STAT|
|anatomical structure maturation|
|dendritic spine|
|regulation of dendrite development|
|hindbrain development|
|negative regulation of neuron projection development|
|positive regulation of intracellular protein transport|
|regulation of macroautophagy|
|pallium development|
|peptidyl-serine phosphorylation|
|regulation of signal transduction by p53 class mediator|
|regulation of cell size|
|negative regulation of cell projection organization|
|negative regulation of cell growth|
|regulation of axonogenesis|
|response to ammonium ion|
|regulation of protein localization to membrane|
|regulation of microtubule cytoskeleton organization|
|positive regulation of supramolecular fiber organization|
|peptidyl-serine modification|
|actin filament binding|
|regulation of neuron apoptotic process|
|positive regulation of intracellular transport|
|gliogenesis|
|regulation of synapse organization|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|negative regulation of neuron differentiation|
|regulation of synapse structure or activity|
|regulation of intracellular protein transport|
|cell recognition|
|protein kinase activity|
|developmental maturation|
|negative regulation of growth|
|positive regulation of protein complex assembly|
|postsynaptic density|
|telencephalon development|
|axon guidance|
|neuron projection guidance|
|rhythmic process|
|positive regulation of cell cycle process|
|negative regulation of neurogenesis|
|axon|
|regulation of cell morphogenesis involved in differentiation|
|cadherin binding|
|regulation of neuron death|
|negative regulation of nervous system development|
|neuron projection|
|positive regulation of cellular protein localization|
|activation of protein kinase activity|
|regulation of developmental growth|
|regulation of autophagy|
|negative regulation of cell development|
|positive regulation of protein serine/threonine kinase activity|
|regulation of actin cytoskeleton organization|
|regulation of intracellular transport|
|regulation of supramolecular fiber organization|
|neuronal cell body|
|axonogenesis|
|positive regulation of cell cycle|
|regulation of cellular component size|
|forebrain development|
|regulation of actin filament-based process|
|cellular response to drug|
|axon development|
|regulation of cell growth|
|dendrite|
|positive regulation of protein transport|
|cell morphogenesis involved in neuron differentiation|
|regulation of protein complex assembly|
|positive regulation of establishment of protein localization|
|synaptic signaling|
|protein kinase binding|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell-cell adhesion|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cellular component biogenesis|
|positive regulation of protein kinase activity|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|chemotaxis|
|regulation of vesicle-mediated transport|
|taxis|
|cell morphogenesis involved in differentiation|
|positive regulation of kinase activity|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|neuron projection development|
|regulation of growth|
|microtubule-based process|
|intracellular membrane-bounded organelle|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|calcium ion binding|
|cell morphogenesis|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|head development|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|regulation of cellular localization|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|cell migration|
|protein phosphorylation|
|regulation of transferase activity|
|embryo development|
|central nervous system development|
|positive regulation of transport|
|regulation of catabolic process|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|cytoskeleton organization|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|G protein-coupled receptor signaling pathway|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9254
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDK5R1 Expression in NALM6 Cells: 3.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>