======= CDK7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDK7
  * **<color #00a2e8>Official Name</color>**: cyclin dependent kinase 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1022|1022]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50613|P50613]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDK7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDK7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601955|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin- dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:9372954, ECO:0000269|PubMed:9840937}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcription factor TFIIK complex|
|cyclin-dependent protein kinase activating kinase holoenzyme complex|
|transcription factor TFIIH holo complex|
|RNA polymerase II CTD heptapeptide repeat kinase activity|
|transcription elongation from RNA polymerase I promoter|
|nucleotide-excision repair, preincision complex assembly|
|cyclin-dependent protein serine/threonine kinase activity|
|termination of RNA polymerase I transcription|
|7-methylguanosine mRNA capping|
|RNA capping|
|7-methylguanosine RNA capping|
|transcription initiation from RNA polymerase I promoter|
|androgen receptor signaling pathway|
|transcription by RNA polymerase I|
|DNA-dependent ATPase activity|
|androgen receptor binding|
|intracellular steroid hormone receptor signaling pathway|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|DNA-templated transcription, termination|
|transcription-coupled nucleotide-excision repair|
|transcription elongation from RNA polymerase II promoter|
|kinase activity|
|DNA-templated transcription, elongation|
|ncRNA transcription|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|nucleotide-excision repair|
|steroid hormone mediated signaling pathway|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|cell cycle arrest|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|transcription initiation from RNA polymerase II promoter|
|protein stabilization|
|cellular response to steroid hormone stimulus|
|protein C-terminus binding|
|protein-DNA complex assembly|
|DNA-templated transcription, initiation|
|protein kinase activity|
|protein-DNA complex subunit organization|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|transcription coactivator activity|
|regulation of protein stability|
|response to steroid hormone|
|protein serine/threonine kinase activity|
|mRNA processing|
|transcription by RNA polymerase II|
|cell division|
|DNA repair|
|regulation of protein serine/threonine kinase activity|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mitotic cell cycle|
|mRNA metabolic process|
|perinuclear region of cytoplasm|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|regulation of protein kinase activity|
|cellular protein-containing complex assembly|
|response to lipid|
|regulation of kinase activity|
|RNA processing|
|response to hormone|
|response to organic cyclic compound|
|protein phosphorylation|
|regulation of transferase activity|
|cell cycle process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|cell cycle|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|regulation of phosphorylation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.37|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.99|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.97|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.88|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.86|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.84|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.82|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.8|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.76|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.74|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-1.74|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-1.72|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.72|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 724/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1842
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDK7 Expression in NALM6 Cells: 4.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>