======= CDKN1C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDKN1C
  * **<color #00a2e8>Official Name</color>**: cyclin dependent kinase inhibitor 1C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1028|1028]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49918|P49918]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDKN1C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDKN1C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600856|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CDI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of lens fiber cell differentiation|
|cyclin-dependent protein serine/threonine kinase inhibitor activity|
|regulation of exit from mitosis|
|uterus development|
|genetic imprinting|
|adrenal gland development|
|embryonic placenta morphogenesis|
|protein kinase inhibitor activity|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of cyclin-dependent protein serine/threonine kinase activity|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of cyclin-dependent protein kinase activity|
|neuron maturation|
|multicellular organism growth|
|embryonic placenta development|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|endocrine system development|
|negative regulation of epithelial cell proliferation|
|negative regulation of protein serine/threonine kinase activity|
|anatomical structure maturation|
|regulation of epithelial cell differentiation|
|digestive system development|
|cell cycle arrest|
|placenta development|
|cell maturation|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|myeloid cell differentiation|
|negative regulation of protein kinase activity|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|developmental maturation|
|negative regulation of kinase activity|
|protein-containing complex binding|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|negative regulation of transferase activity|
|aging|
|renal system development|
|camera-type eye development|
|urogenital system development|
|regulation of epithelial cell proliferation|
|eye development|
|visual system development|
|sensory system development|
|in utero embryonic development|
|developmental growth|
|growth|
|negative regulation of protein phosphorylation|
|gland development|
|regulation of mitotic cell cycle phase transition|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|negative regulation of phosphorylation|
|regulation of cell cycle phase transition|
|skeletal system development|
|regulation of protein serine/threonine kinase activity|
|sensory organ development|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|embryonic morphogenesis|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|hematopoietic or lymphoid organ development|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|regulation of cell cycle process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|neuron development|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|regulation of transferase activity|
|embryo development|
|cell cycle process|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp453|B02 10μM R08 exp453]]|1.71|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13245
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDKN1C Expression in NALM6 Cells: 1.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>