======= CEBPZ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CEBPZ
  * **<color #00a2e8>Official Name</color>**: CCAAT enhancer binding protein zeta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10153|10153]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q03701|Q03701]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CEBPZ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CEBPZ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612828|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the CEBP family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. Methylation of the promoter of this gene or mutations within the gene may be correlated with occurance of acute myeloid leukemia (AML). [provided by RefSeq, Jun 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Stimulates transcription from the HSP70 promoter.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CBF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosome biogenesis|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|ribonucleoprotein complex biogenesis|
|transcription by RNA polymerase II|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|RNA binding|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.27|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.92|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.81|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.7|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.7|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.71|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.78|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.78|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|1.8|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.83|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.86|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.87|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.88|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.89|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.25|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.533|
|[[:human genes:p:psmb4|PSMB4]]|0.5|
|[[:human genes:c:cactin|CACTIN]]|0.47|
|[[:human genes:r:rpl35|RPL35]]|0.465|
|[[:human genes:a:acsf2|ACSF2]]|0.452|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.449|
|[[:human genes:p:psmb1|PSMB1]]|0.448|
|[[:human genes:n:nupl1|NUPL1]]|0.446|
|[[:human genes:m:mt1e|MT1E]]|0.443|
|[[:human genes:c:cbwd6|CBWD6]]|0.435|
|[[:human genes:t:timeless|TIMELESS]]|0.434|
|[[:human genes:p:pola1|POLA1]]|0.43|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.428|
|[[:human genes:s:supt5h|SUPT5H]]|0.427|
|[[:human genes:r:rpl38|RPL38]]|0.421|
|[[:human genes:d:ddx56|DDX56]]|0.419|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.418|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.417|
|[[:human genes:n:npipb5|NPIPB5]]|0.415|
|[[:human genes:s:sap30bp|SAP30BP]]|0.414|
|[[:human genes:t:tceb3c|TCEB3C]]|0.413|
|[[:human genes:c:ccdc116|CCDC116]]|0.412|
|[[:human genes:d:dnm2|DNM2]]|0.412|
|[[:human genes:p:pole|POLE]]|0.408|
|[[:human genes:n:narfl|NARFL]]|0.403|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.401|
|[[:human genes:i:ints5|INTS5]]|0.401|
|[[:human genes:u:upf1|UPF1]]|0.4|
|[[:human genes:c:cbwd3|CBWD3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 197/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|9/28|
|bone|10/26|
|breast|9/33|
|central nervous system|21/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|2/13|
|fibroblast|1/1|
|gastric|5/16|
|kidney|8/21|
|liver|1/20|
|lung|16/75|
|lymphocyte|5/16|
|ovary|4/26|
|pancreas|8/24|
|peripheral nervous system|5/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|7/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 116
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CEBPZ Expression in NALM6 Cells: 6.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>