======= CENPW =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CENPW
  * **<color #00a2e8>Official Name</color>**: centromere protein W
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=387103|387103]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5EE01|Q5EE01]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CENPW&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CENPW|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611264|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000250, ECO:0000269|PubMed:19070575, ECO:0000269|PubMed:19533040, ECO:0000269|PubMed:21695110, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22304917}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|kinetochore assembly|
|kinetochore organization|
|CENP-A containing nucleosome assembly|
|CENP-A containing chromatin organization|
|chromatin remodeling at centromere|
|centromere complex assembly|
|DNA replication-independent nucleosome assembly|
|DNA replication-independent nucleosome organization|
|histone exchange|
|chromosome, centromeric region|
|ATP-dependent chromatin remodeling|
|kinetochore|
|condensed chromosome kinetochore|
|spindle assembly|
|nuclear matrix|
|nucleosome assembly|
|chromatin assembly|
|spindle organization|
|chromatin assembly or disassembly|
|nucleosome organization|
|chromatin remodeling|
|DNA packaging|
|protein-DNA complex assembly|
|protein-DNA complex subunit organization|
|chromosome segregation|
|DNA conformation change|
|microtubule cytoskeleton organization|
|protein heterodimerization activity|
|cell division|
|microtubule-based process|
|mitotic cell cycle|
|chromatin organization|
|organelle assembly|
|cellular protein-containing complex assembly|
|nucleolus|
|cell cycle process|
|chromosome organization|
|cytoskeleton organization|
|cell cycle|
|DNA binding|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-3.13|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.37|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-2.16|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.07|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.04|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.03|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.91|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.75|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.73|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.71|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 717/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|14/15|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1301
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CENPW Expression in NALM6 Cells: 4.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>