======= CEP120 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CEP120
  * **<color #00a2e8>Official Name</color>**: centrosomal protein 120
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=153241|153241]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N960|Q8N960]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CEP120&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CEP120|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613446|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar protein in mouse plays a role in both interkinetic nuclear migration, which is a characteristic pattern of nuclear movement in neural progenitors, and in neural progenitor self-renewal. Mutations in this gene are predicted to result in neurogenic defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis (By similarity). {ECO:0000250|UniProtKB:Q7TSG1}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3668|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of centriole elongation|
|interkinetic nuclear migration|
|regulation of centriole elongation|
|positive regulation of centriole replication|
|astral microtubule organization|
|positive regulation of centrosome duplication|
|positive regulation of centrosome cycle|
|regulation of centriole replication|
|nuclear migration|
|positive regulation of cilium assembly|
|nucleus localization|
|cell proliferation in forebrain|
|regulation of centrosome duplication|
|cytoplasmic microtubule organization|
|regulation of centrosome cycle|
|positive regulation of organelle assembly|
|neural precursor cell proliferation|
|regulation of cilium assembly|
|centrosome cycle|
|microtubule organizing center organization|
|positive regulation of plasma membrane bounded cell projection assembly|
|cerebral cortex development|
|centriole|
|spindle organization|
|pallium development|
|protein C-terminus binding|
|regulation of microtubule cytoskeleton organization|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|positive regulation of cytoskeleton organization|
|regulation of organelle assembly|
|regulation of microtubule-based process|
|telencephalon development|
|positive regulation of cell cycle process|
|establishment of organelle localization|
|positive regulation of cell cycle|
|positive regulation of cell projection organization|
|forebrain development|
|supramolecular fiber organization|
|positive regulation of establishment of protein localization|
|microtubule cytoskeleton organization|
|centrosome|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|cell population proliferation|
|organelle localization|
|positive regulation of organelle organization|
|microtubule-based process|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|brain development|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|head development|
|regulation of cellular component biogenesis|
|central nervous system development|
|cell cycle process|
|regulation of protein localization|
|cytoskeleton organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|intracellular transport|
|neurogenesis|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.73|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.71|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.83|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.83|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|4.57|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|5.17|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|6.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c2cd3|C2CD3]]|0.68|
|[[:human genes:c:c14orf80|C14orf80]]|0.679|
|[[:human genes:c:cradd|CRADD]]|0.628|
|[[:human genes:c:c16orf59|C16orf59]]|0.624|
|[[:human genes:o:odf2|ODF2]]|0.612|
|[[:human genes:p:pidd|PIDD]]|0.606|
|[[:human genes:c:casp2|CASP2]]|0.598|
|[[:human genes:t:tubd1|TUBD1]]|0.596|
|[[:human genes:k:kiaa0753|KIAA0753]]|0.591|
|[[:human genes:o:ofd1|OFD1]]|0.576|
|[[:human genes:p:pibf1|PIBF1]]|0.57|
|[[:human genes:n:nin|NIN]]|0.56|
|[[:human genes:s:sclt1|SCLT1]]|0.547|
|[[:human genes:c:cep44|CEP44]]|0.547|
|[[:human genes:t:tube1|TUBE1]]|0.545|
|[[:human genes:c:cep128|CEP128]]|0.536|
|[[:human genes:c:ccdc41|CCDC41]]|0.535|
|[[:human genes:c:cep76|CEP76]]|0.52|
|[[:human genes:a:ankrd26|ANKRD26]]|0.513|
|[[:human genes:h:hyls1|HYLS1]]|0.508|
|[[:human genes:r:rttn|RTTN]]|0.496|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.483|
|[[:human genes:f:fopnl|FOPNL]]|0.46|
|[[:human genes:h:hspa4|HSPA4]]|0.443|
|[[:human genes:i:ipp|IPP]]|0.431|
|[[:human genes:s:srp9|SRP9]]|0.43|
|[[:human genes:c:cep152|CEP152]]|0.42|
|[[:human genes:k:kiaa1731|KIAA1731]]|0.418|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6789
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CEP120 Expression in NALM6 Cells: 5.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>