======= CEP250 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CEP250
  * **<color #00a2e8>Official Name</color>**: centrosomal protein 250
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11190|11190]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BV73|Q9BV73]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CEP250&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CEP250|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609689|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probably plays an important role in centrosome cohesion during interphase.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of centriole-centriole cohesion|
|positive regulation of protein localization to centrosome|
|regulation of protein localization to centrosome|
|centriole-centriole cohesion|
|detection of light stimulus involved in sensory perception|
|detection of light stimulus involved in visual perception|
|non-motile cilium assembly|
|detection of visible light|
|photoreceptor inner segment|
|regulation of centrosome cycle|
|photoreceptor outer segment|
|detection of light stimulus|
|centrosome cycle|
|microtubule organizing center organization|
|ciliary basal body-plasma membrane docking|
|detection of external stimulus|
|detection of abiotic stimulus|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|ciliary basal body|
|centriole|
|microtubule organizing center|
|organelle localization by membrane tethering|
|membrane docking|
|protein C-terminus binding|
|regulation of microtubule cytoskeleton organization|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|visual perception|
|regulation of microtubule-based process|
|sensory perception of light stimulus|
|protein domain specific binding|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|response to light stimulus|
|positive regulation of cellular protein localization|
|cilium assembly|
|cilium organization|
|regulation of mitotic cell cycle phase transition|
|response to radiation|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|protein kinase binding|
|microtubule cytoskeleton organization|
|centrosome|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|detection of stimulus involved in sensory perception|
|organelle localization|
|protein-containing complex|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|detection of stimulus|
|perinuclear region of cytoplasm|
|protein localization to organelle|
|regulation of cell cycle process|
|organelle assembly|
|regulation of cellular localization|
|sensory perception|
|cell cycle process|
|regulation of protein localization|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|response to abiotic stimulus|
|cell projection organization|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|nervous system process|
|cellular protein localization|
|cellular macromolecule localization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6618
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CEP250 Expression in NALM6 Cells: 7.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>