======= CEP350 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CEP350
  * **<color #00a2e8>Official Name</color>**: centrosomal protein 350
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9857|9857]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5VT06|Q5VT06]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CEP350&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CEP350|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617870|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CAP GLY|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microtubule anchoring|
|cell projection|
|spindle|
|centriole|
|microtubule binding|
|microtubule cytoskeleton organization|
|centrosome|
|microtubule-based process|
|cytoskeleton organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.75|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.86|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.97|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.01|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.04|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.12|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.3|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.776|
|[[:human genes:h:hspd1|HSPD1]]|0.526|
|[[:human genes:m:mars|MARS]]|0.499|
|[[:human genes:s:spcs2|SPCS2]]|0.475|
|[[:human genes:r:rnmt|RNMT]]|0.459|
|[[:human genes:e:eprs|EPRS]]|0.444|
|[[:human genes:g:gmppb|GMPPB]]|0.438|
|[[:human genes:c:csnk2b|CSNK2B]]|0.433|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.433|
|[[:human genes:p:pisd|PISD]]|0.416|
|[[:human genes:d:dhdds|DHDDS]]|0.412|
|[[:human genes:p:pelo|PELO]]|0.412|
|[[:human genes:r:rptor|RPTOR]]|0.408|
|[[:human genes:n:nsmce1|NSMCE1]]|0.407|
|[[:human genes:n:nars|NARS]]|0.406|
|[[:human genes:n:nae1|NAE1]]|0.404|
|[[:human genes:d:dad1|DAD1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2057
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CEP350 Expression in NALM6 Cells: 7.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>