======= CEP57 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CEP57
  * **<color #00a2e8>Official Name</color>**: centrosomal protein 57
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9702|9702]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86XR8|Q86XR8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CEP57&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CEP57|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607951|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1167|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fibroblast growth factor binding|
|gamma-tubulin binding|
|microtubule anchoring|
|fibroblast growth factor receptor signaling pathway|
|ciliary basal body-plasma membrane docking|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|spermatid development|
|spermatid differentiation|
|organelle localization by membrane tethering|
|membrane docking|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|microtubule binding|
|germ cell development|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|microtubule|
|protein homooligomerization|
|cilium assembly|
|cellular process involved in reproduction in multicellular organism|
|cilium organization|
|regulation of mitotic cell cycle phase transition|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|microtubule cytoskeleton organization|
|centrosome|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|protein complex oligomerization|
|response to growth factor|
|spermatogenesis|
|male gamete generation|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|developmental process involved in reproduction|
|microtubule-based process|
|mitotic cell cycle|
|gamete generation|
|enzyme linked receptor protein signaling pathway|
|regulation of cell cycle process|
|organelle assembly|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|protein homodimerization activity|
|Golgi apparatus|
|multi-organism reproductive process|
|cell cycle process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|cell cycle|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|protein-containing complex assembly|
|cell development|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-2.6|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.45|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-2.43|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.33|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.26|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-2.25|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-2.16|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.01|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.97|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-1.96|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.94|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.94|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.91|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.87|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.87|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.86|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.86|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-1.84|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.83|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-1.82|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.77|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.75|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.72|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-1.71|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.71|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.98|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.99|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.02|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.2|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|2.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.553|
|[[:human genes:s:srp14|SRP14]]|0.527|
|[[:human genes:t:triap1|TRIAP1]]|0.524|
|[[:human genes:r:rpp21|RPP21]]|0.518|
|[[:human genes:t:ten1|TEN1]]|0.509|
|[[:human genes:g:gemin6|GEMIN6]]|0.507|
|[[:human genes:v:vezt|VEZT]]|0.506|
|[[:human genes:d:dpagt1|DPAGT1]]|0.505|
|[[:human genes:g:gemin8|GEMIN8]]|0.505|
|[[:human genes:g:gemin7|GEMIN7]]|0.5|
|[[:human genes:r:rtcb|RTCB]]|0.5|
|[[:human genes:a:atxn10|ATXN10]]|0.489|
|[[:human genes:p:pmm2|PMM2]]|0.486|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.481|
|[[:human genes:t:trmt5|TRMT5]]|0.479|
|[[:human genes:g:gmppb|GMPPB]]|0.479|
|[[:human genes:z:zrsr2|ZRSR2]]|0.478|
|[[:human genes:a:adsl|ADSL]]|0.477|
|[[:human genes:u:uap1|UAP1]]|0.477|
|[[:human genes:n:nae1|NAE1]]|0.477|
|[[:human genes:p:ppcs|PPCS]]|0.474|
|[[:human genes:a:alg1|ALG1]]|0.469|
|[[:human genes:t:tamm41|TAMM41]]|0.468|
|[[:human genes:p:pdss1|PDSS1]]|0.463|
|[[:human genes:s:slc25a26|SLC25A26]]|0.46|
|[[:human genes:r:rpia|RPIA]]|0.459|
|[[:human genes:t:trmt10a|TRMT10A]]|0.453|
|[[:human genes:t:tpk1|TPK1]]|0.45|
|[[:human genes:a:alg13|ALG13]]|0.448|
|[[:human genes:n:nbn|NBN]]|0.447|
|[[:human genes:t:tprkb|TPRKB]]|0.446|
|[[:human genes:l:lsm10|LSM10]]|0.439|
|[[:human genes:d:dnlz|DNLZ]]|0.438|
|[[:human genes:e:exoc4|EXOC4]]|0.437|
|[[:human genes:p:pgs1|PGS1]]|0.433|
|[[:human genes:p:pgm3|PGM3]]|0.433|
|[[:human genes:r:rabggtb|RABGGTB]]|0.432|
|[[:human genes:t:trmt61a|TRMT61A]]|0.43|
|[[:human genes:t:ttc4|TTC4]]|0.428|
|[[:human genes:t:trmt6|TRMT6]]|0.424|
|[[:human genes:e:eprs|EPRS]]|0.423|
|[[:human genes:s:snapc5|SNAPC5]]|0.423|
|[[:human genes:g:gfpt1|GFPT1]]|0.422|
|[[:human genes:p:ppcdc|PPCDC]]|0.421|
|[[:human genes:r:rptor|RPTOR]]|0.42|
|[[:human genes:u:uhrf1|UHRF1]]|0.419|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.418|
|[[:human genes:p:ppp6c|PPP6C]]|0.418|
|[[:human genes:t:taf1a|TAF1A]]|0.417|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.416|
|[[:human genes:t:tsen54|TSEN54]]|0.415|
|[[:human genes:p:polr3h|POLR3H]]|0.414|
|[[:human genes:m:mrps16|MRPS16]]|0.412|
|[[:human genes:r:rnmt|RNMT]]|0.412|
|[[:human genes:a:atic|ATIC]]|0.409|
|[[:human genes:w:wdr92|WDR92]]|0.408|
|[[:human genes:a:atm|ATM]]|0.405|
|[[:human genes:d:dohh|DOHH]]|0.403|
|[[:human genes:r:rpe|RPE]]|0.403|
|[[:human genes:s:slc25a19|SLC25A19]]|0.403|
|[[:human genes:u:uba3|UBA3]]|0.402|
|[[:human genes:t:taz|TAZ]]|0.402|
|[[:human genes:e:elac2|ELAC2]]|0.401|
|[[:human genes:r:romo1|ROMO1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5122
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CEP57 Expression in NALM6 Cells: 7.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>