======= CEP78 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CEP78
  * **<color #00a2e8>Official Name</color>**: centrosomal protein 78
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84131|84131]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5JTW2|Q5JTW2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CEP78&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CEP78|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617110|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a centrosomal protein that is both required for the regulation of centrosome-related events during the cell cycle, and required for ciliogenesis. The encoded protein has an N-terminal leucine-rich repeat (LRR) domain with six consecutive LRR repeats, and a C-terminal coiled-coil domain. It interacts with the N-terminal catalytic domain of polo-like kinase 4 (PLK4) and colocalizes with PLK4 to the distal end of the centriole. Naturally occurring mutations in this gene cause defects in primary cilia that result in retinal degeneration and sensorineural hearing loss which are associated with cone-rod degeneration disease as well as Usher syndrome. Low expression of this gene is associated with poor prognosis of colorectal cancer patients. [provided by RefSeq, Mar 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles (PubMed:27246242). May play a role in cilium biogenesis (PubMed:27588451). {ECO:0000269|PubMed:27246242, ECO:0000269|PubMed:27588451}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ciliary basal body-plasma membrane docking|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|ciliary basal body|
|centriole|
|organelle localization by membrane tethering|
|membrane docking|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|cilium assembly|
|cilium organization|
|regulation of mitotic cell cycle phase transition|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|centrosome|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|regulation of cell cycle process|
|organelle assembly|
|cell cycle process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.8|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.73|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.77|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.82|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.91|
|[[:results:exp340|BN82002 4μM R07 exp340]]|2.26|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.39|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|3.62|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|3.75|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|5.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ccdc41|CCDC41]]|0.587|
|[[:human genes:c:casp2|CASP2]]|0.581|
|[[:human genes:c:cradd|CRADD]]|0.563|
|[[:human genes:o:ofd1|OFD1]]|0.544|
|[[:human genes:k:kiaa0753|KIAA0753]]|0.528|
|[[:human genes:c:c2cd3|C2CD3]]|0.522|
|[[:human genes:p:pidd|PIDD]]|0.511|
|[[:human genes:n:nin|NIN]]|0.508|
|[[:human genes:p:pibf1|PIBF1]]|0.503|
|[[:human genes:o:odf2|ODF2]]|0.502|
|[[:human genes:t:tubd1|TUBD1]]|0.495|
|[[:human genes:a:ankrd26|ANKRD26]]|0.471|
|[[:human genes:f:fopnl|FOPNL]]|0.463|
|[[:human genes:c:cep128|CEP128]]|0.45|
|[[:human genes:s:sclt1|SCLT1]]|0.449|
|[[:human genes:c:c14orf80|C14orf80]]|0.424|
|[[:human genes:c:c16orf59|C16orf59]]|0.419|
|[[:human genes:c:cep76|CEP76]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18460
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CEP78 Expression in NALM6 Cells: 7.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>