======= CERK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CERK
  * **<color #00a2e8>Official Name</color>**: ceramide kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64781|64781]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TCT0|Q8TCT0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CERK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CERK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610307|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides. {ECO:0000269|PubMed:19168031}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DAGK cat|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dihydroceramide kinase activity|
|ceramide kinase activity|
|NAD+ kinase activity|
|glycosphingolipid metabolic process|
|lipid phosphorylation|
|ceramide metabolic process|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|sphingolipid metabolic process|
|lipid modification|
|membrane lipid metabolic process|
|magnesium ion binding|
|cellular amide metabolic process|
|cellular lipid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|phosphorylation|
|ATP binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-2.03|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.95|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.78|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.74|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.75|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.82|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.04|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.05|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|2.12|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8839
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CERK Expression in NALM6 Cells: 5.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>