======= CES1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CES1
  * **<color #00a2e8>Official Name</color>**: carboxylesterase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1066|1066]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23141|P23141]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CES1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CES1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114835|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COesterase|
|Abhydrolase 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cholesterol ester hydrolysis involved in cholesterol transport|
|vesicle-mediated cholesterol transport|
|methylumbelliferyl-acetate deacetylase activity|
|methyl indole-3-acetate esterase activity|
|sterol esterase activity|
|medium-chain fatty acid metabolic process|
|regulation of angiotensin levels in blood|
|angiotensin maturation|
|regulation of systemic arterial blood pressure by circulatory renin-angiotensin|
|intracellular cholesterol transport|
|intracellular sterol transport|
|triglyceride lipase activity|
|regulation of systemic arterial blood pressure by renin-angiotensin|
|carboxylic ester hydrolase activity|
|peptide hormone processing|
|intracellular lipid transport|
|regulation of systemic arterial blood pressure by hormone|
|cholesterol biosynthetic process|
|secondary alcohol biosynthetic process|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|sterol biosynthetic process|
|endocrine process|
|cholesterol transport|
|sterol transport|
|regulation of systemic arterial blood pressure|
|alcohol biosynthetic process|
|cholesterol metabolic process|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|xenobiotic metabolic process|
|sterol metabolic process|
|organic hydroxy compound transport|
|cytosolic transport|
|protein processing|
|regulation of blood pressure|
|organic hydroxy compound biosynthetic process|
|cellular response to xenobiotic stimulus|
|hormone metabolic process|
|protein maturation|
|steroid metabolic process|
|lipid transport|
|lipid catabolic process|
|response to xenobiotic stimulus|
|endoplasmic reticulum lumen|
|alcohol metabolic process|
|lipid localization|
|fatty acid metabolic process|
|blood circulation|
|circulatory system process|
|organic hydroxy compound metabolic process|
|response to toxic substance|
|peptide metabolic process|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|epithelial cell differentiation|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|endoplasmic reticulum|
|organic acid metabolic process|
|epithelium development|
|lipid metabolic process|
|proteolysis|
|organic cyclic compound biosynthetic process|
|intracellular transport|
|extracellular space|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|establishment of localization in cell|
|vesicle-mediated transport|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5167
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CES1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>