======= CFLAR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CFLAR
  * **<color #00a2e8>Official Name</color>**: CASP8 and FADD like apoptosis regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8837|8837]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15519|O15519]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CFLAR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CFLAR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603599|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DED|
|Peptidase C14|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of hepatocyte apoptotic process|
|regulation of hepatocyte apoptotic process|
|negative regulation of myoblast fusion|
|negative regulation of syncytium formation by plasma membrane fusion|
|positive regulation of glomerular mesangial cell proliferation|
|ripoptosome|
|CD95 death-inducing signaling complex|
|death-inducing signaling complex|
|skeletal muscle atrophy|
|positive regulation of cell proliferation involved in kidney development|
|striated muscle atrophy|
|positive regulation of hepatocyte proliferation|
|muscle atrophy|
|regulation of glomerular mesangial cell proliferation|
|peptidase activator activity|
|positive regulation of glomerulus development|
|skeletal muscle adaptation|
|negative regulation of necroptotic process|
|negative regulation of programmed necrotic cell death|
|regulation of skeletal muscle satellite cell proliferation|
|regulation of skeletal muscle cell proliferation|
|regulation of hepatocyte proliferation|
|regulation of cell proliferation involved in kidney development|
|death receptor binding|
|regulation of glomerulus development|
|cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of necrotic cell death|
|cellular response to nitric oxide|
|skeletal myofibril assembly|
|regulation of necroptotic process|
|cellular response to reactive nitrogen species|
|response to nitric oxide|
|negative regulation of myotube differentiation|
|regulation of programmed necrotic cell death|
|positive regulation of extracellular matrix organization|
|regulation of myoblast fusion|
|negative regulation of cardiac muscle cell apoptotic process|
|negative regulation of striated muscle cell apoptotic process|
|negative regulation of reactive oxygen species biosynthetic process|
|striated muscle adaptation|
|regulation of necrotic cell death|
|regulation of syncytium formation by plasma membrane fusion|
|cellular response to dexamethasone stimulus|
|muscle adaptation|
|skeletal muscle tissue regeneration|
|cellular response to estradiol stimulus|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|negative regulation of muscle cell apoptotic process|
|regulation of cardiac muscle cell apoptotic process|
|regulation of extracellular matrix organization|
|negative regulation of striated muscle cell differentiation|
|response to testosterone|
|regulation of striated muscle cell apoptotic process|
|response to dexamethasone|
|positive regulation of kidney development|
|negative regulation of epithelial cell apoptotic process|
|cellular response to epidermal growth factor stimulus|
|enzyme activator activity|
|response to epidermal growth factor|
|response to bronchodilator|
|negative regulation of reactive oxygen species metabolic process|
|negative regulation of muscle cell differentiation|
|regulation of kidney development|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|cellular response to glucocorticoid stimulus|
|regulation of myotube differentiation|
|cellular response to corticosteroid stimulus|
|tissue regeneration|
|myofibril assembly|
|regulation of muscle cell apoptotic process|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|regulation of epithelial cell apoptotic process|
|positive regulation of animal organ morphogenesis|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of reactive oxygen species biosynthetic process|
|negative regulation of cysteine-type endopeptidase activity|
|cellular response to ketone|
|response to antineoplastic agent|
|regulation of striated muscle cell differentiation|
|negative regulation of extrinsic apoptotic signaling pathway|
|protease binding|
|cellular component assembly involved in morphogenesis|
|actomyosin structure organization|
|regulation of cellular response to transforming growth factor beta stimulus|
|skeletal muscle tissue development|
|cellular response to reactive oxygen species|
|skeletal muscle organ development|
|striated muscle cell development|
|response to estradiol|
|response to glucocorticoid|
|negative regulation of cellular response to growth factor stimulus|
|muscle cell development|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of muscle cell differentiation|
|regulation of extrinsic apoptotic signaling pathway|
|regeneration|
|response to corticosteroid|
|cellular response to insulin stimulus|
|regulation of reactive oxygen species metabolic process|
|positive regulation of vasculature development|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to xenobiotic stimulus|
|cellular response to steroid hormone stimulus|
|cellular response to hypoxia|
|positive regulation of epithelial cell proliferation|
|positive regulation of peptidase activity|
|response to ketone|
|response to reactive oxygen species|
|cellular response to decreased oxygen levels|
|striated muscle cell differentiation|
|positive regulation of ERK1 and ERK2 cascade|
|cellular response to oxygen levels|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular response to inorganic substance|
|negative regulation of apoptotic signaling pathway|
|membrane raft|
|response to insulin|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to oxidative stress|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|muscle cell differentiation|
|negative regulation of peptidase activity|
|regulation of animal organ morphogenesis|
|positive regulation of DNA-binding transcription factor activity|
|protein-containing complex binding|
|cellular response to peptide hormone stimulus|
|regulation of cellular response to growth factor stimulus|
|positive regulation of neuron projection development|
|striated muscle tissue development|
|regulation of ERK1 and ERK2 cascade|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|response to xenobiotic stimulus|
|regulation of vasculature development|
|cellular response to peptide|
|response to steroid hormone|
|regulation of epithelial cell proliferation|
|response to hypoxia|
|negative regulation of proteolysis|
|response to decreased oxygen levels|
|positive regulation of proteolysis|
|positive regulation of neuron differentiation|
|response to oxygen levels|
|positive regulation of cell projection organization|
|response to oxidative stress|
|developmental growth|
|response to peptide hormone|
|growth|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|regulation of endopeptidase activity|
|regulation of DNA-binding transcription factor activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|supramolecular fiber organization|
|positive regulation of neurogenesis|
|response to peptide|
|muscle structure development|
|wound healing|
|protein heterodimerization activity|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|cellular response to lipid|
|response to growth factor|
|response to inorganic substance|
|positive regulation of nervous system development|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|actin filament-based process|
|response to wounding|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|response to bacterium|
|regulation of plasma membrane bounded cell projection organization|
|viral process|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|regulation of MAPK cascade|
|organelle assembly|
|positive regulation of hydrolase activity|
|symbiotic process|
|negative regulation of catalytic activity|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|response to lipid|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|cell death|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-3.66|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-2.94|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.49|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.44|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.21|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-2.2|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-2.1|
|[[:results:exp275|Citral 75μM R06 exp275]]|-2.03|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.95|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.77|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.76|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.75|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.73|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 204/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|16/28|
|blood|6/28|
|bone|0/26|
|breast|9/33|
|central nervous system|6/56|
|cervix|0/4|
|colorectal|5/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|14/21|
|liver|6/20|
|lung|30/75|
|lymphocyte|7/16|
|ovary|12/26|
|pancreas|12/24|
|peripheral nervous system|1/16|
|plasma cell|11/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|11/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10914
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CFLAR Expression in NALM6 Cells: 6.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>