======= CHAC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHAC1
  * **<color #00a2e8>Official Name</color>**: ChaC glutathione specific gamma-glutamylcyclotransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79094|79094]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BUX1|Q9BUX1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHAC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHAC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614587|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the gamma-glutamylcyclotransferase family of proteins. The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signaling. This protein may also play a role in the unfolded protein response, and in regulation of glutathione levels and oxidative balance in the cell. Elevated expression of this gene may indicate increased risk of cancer recurrence among breast and ovarian cancer patients. [provided by RefSeq, Sep 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623). Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366). {ECO:0000269|PubMed:19109178, ECO:0000269|PubMed:22445366, ECO:0000269|PubMed:27913623}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ChaC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glutathione specific gamma-glutamylcyclotransferase activity|
|gamma-glutamylcyclotransferase activity|
|glutathione catabolic process|
|glutathione biosynthetic process|
|nonribosomal peptide biosynthetic process|
|Notch binding|
|peptide catabolic process|
|cellular modified amino acid catabolic process|
|negative regulation of protein processing|
|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|
|negative regulation of protein maturation|
|negative regulation of Notch signaling pathway|
|cellular modified amino acid biosynthetic process|
|sulfur compound catabolic process|
|glutathione metabolic process|
|cofactor catabolic process|
|regulation of protein processing|
|regulation of protein maturation|
|regulation of Notch signaling pathway|
|Notch signaling pathway|
|intrinsic apoptotic signaling pathway|
|response to unfolded protein|
|trans-Golgi network|
|sulfur compound biosynthetic process|
|response to topologically incorrect protein|
|cellular modified amino acid metabolic process|
|cofactor biosynthetic process|
|response to endoplasmic reticulum stress|
|apoptotic signaling pathway|
|negative regulation of proteolysis|
|sulfur compound metabolic process|
|peptide biosynthetic process|
|cofactor metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|regulation of proteolysis|
|cellular amide metabolic process|
|apoptotic process|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|cell death|
|negative regulation of protein metabolic process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|organonitrogen compound biosynthetic process|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-1.89|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.8|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.79|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.7|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|1.86|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.95|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.03|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8487
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHAC1 Expression in NALM6 Cells: 2.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>