======= CHAF1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHAF1A
  * **<color #00a2e8>Official Name</color>**: chromatin assembly factor 1 subunit A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10036|10036]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13111|Q13111]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHAF1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHAF1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601246|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity). {ECO:0000250, ECO:0000269|PubMed:15327775}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CAF-1 p150|
|CAF1A|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CAF-1 complex|
|chromo shadow domain binding|
|DNA replication-dependent nucleosome organization|
|DNA replication-dependent nucleosome assembly|
|nucleosome assembly|
|unfolded protein binding|
|chromatin assembly|
|chromatin assembly or disassembly|
|nucleosome organization|
|DNA packaging|
|protein-DNA complex assembly|
|DNA replication|
|nuclear chromatin|
|protein-DNA complex subunit organization|
|DNA conformation change|
|chromatin binding|
|DNA repair|
|protein-containing complex|
|chromatin organization|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular protein-containing complex assembly|
|chromosome organization|
|identical protein binding|
|cell cycle|
|protein-containing complex assembly|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-2.33|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-2.16|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-2.15|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-2.03|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.91|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.85|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.7|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.72|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.74|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.76|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.79|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.83|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|1.83|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.85|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|1.87|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.88|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.88|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.92|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.93|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.94|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.94|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.98|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.99|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.02|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.1|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|2.11|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|2.11|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|2.12|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|2.15|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|2.32|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|2.32|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.33|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|2.57|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|3.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3c|TCEB3C]]|0.581|
|[[:human genes:p:psmb4|PSMB4]]|0.57|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.55|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.549|
|[[:human genes:t:ticrr|TICRR]]|0.543|
|[[:human genes:v:vasn|VASN]]|0.535|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.535|
|[[:human genes:c:ccna2|CCNA2]]|0.528|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.518|
|[[:human genes:p:psmb2|PSMB2]]|0.514|
|[[:human genes:z:znf830|ZNF830]]|0.509|
|[[:human genes:a:ankle2|ANKLE2]]|0.509|
|[[:human genes:s:snrpa1|SNRPA1]]|0.502|
|[[:human genes:c:cope|COPE]]|0.5|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.498|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.494|
|[[:human genes:c:copg1|COPG1]]|0.493|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.493|
|[[:human genes:n:nup153|NUP153]]|0.493|
|[[:human genes:t:tfip11|TFIP11]]|0.492|
|[[:human genes:v:vps28|VPS28]]|0.489|
|[[:human genes:i:ik|IK]]|0.487|
|[[:human genes:u:upf1|UPF1]]|0.487|
|[[:human genes:e:exosc9|EXOSC9]]|0.484|
|[[:human genes:a:aqr|AQR]]|0.48|
|[[:human genes:r:rad51|RAD51]]|0.48|
|[[:human genes:p:polr2j3|POLR2J3]]|0.48|
|[[:human genes:c:cbwd3|CBWD3]]|0.479|
|[[:human genes:s:slc4a1|SLC4A1]]|0.477|
|[[:human genes:p:pdcd11|PDCD11]]|0.476|
|[[:human genes:r:rpl35|RPL35]]|0.473|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.471|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.471|
|[[:human genes:c:chd4|CHD4]]|0.47|
|[[:human genes:c:cbwd5|CBWD5]]|0.47|
|[[:human genes:i:igfn1|IGFN1]]|0.469|
|[[:human genes:p:pno1|PNO1]]|0.468|
|[[:human genes:c:copb1|COPB1]]|0.468|
|[[:human genes:p:prim1|PRIM1]]|0.468|
|[[:human genes:p:psmc1|PSMC1]]|0.467|
|[[:human genes:p:psmc2|PSMC2]]|0.465|
|[[:human genes:c:cactin|CACTIN]]|0.462|
|[[:human genes:n:nup160|NUP160]]|0.462|
|[[:human genes:t:tyms|TYMS]]|0.462|
|[[:human genes:l:lrr1|LRR1]]|0.46|
|[[:human genes:s:supt5h|SUPT5H]]|0.46|
|[[:human genes:n:nupl1|NUPL1]]|0.459|
|[[:human genes:k:kctd17|KCTD17]]|0.459|
|[[:human genes:x:xylt2|XYLT2]]|0.458|
|[[:human genes:s:slc6a17|SLC6A17]]|0.458|
|[[:human genes:p:prpf8|PRPF8]]|0.457|
|[[:human genes:d:dock6|DOCK6]]|0.455|
|[[:human genes:a:arcn1|ARCN1]]|0.455|
|[[:human genes:r:rps5|RPS5]]|0.454|
|[[:human genes:s:sec13|SEC13]]|0.454|
|[[:human genes:g:gar1|GAR1]]|0.454|
|[[:human genes:r:rrp7a|RRP7A]]|0.454|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.453|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.452|
|[[:human genes:d:dido1|DIDO1]]|0.452|
|[[:human genes:p:psma6|PSMA6]]|0.452|
|[[:human genes:p:psmd7|PSMD7]]|0.452|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.452|
|[[:human genes:p:psmd3|PSMD3]]|0.451|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.451|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.451|
|[[:human genes:m:mt1e|MT1E]]|0.45|
|[[:human genes:p:pan3|PAN3]]|0.45|
|[[:human genes:n:nol12|NOL12]]|0.449|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.449|
|[[:human genes:t:tpx2|TPX2]]|0.447|
|[[:human genes:p:pole|POLE]]|0.447|
|[[:human genes:d:dtl|DTL]]|0.446|
|[[:human genes:e:eif4a3|EIF4A3]]|0.446|
|[[:human genes:c:cnot1|CNOT1]]|0.446|
|[[:human genes:p:psmc5|PSMC5]]|0.443|
|[[:human genes:e:exd1|EXD1]]|0.443|
|[[:human genes:c:cdh24|CDH24]]|0.443|
|[[:human genes:c:ctage4|CTAGE4]]|0.442|
|[[:human genes:r:riok2|RIOK2]]|0.44|
|[[:human genes:z:znf574|ZNF574]]|0.438|
|[[:human genes:e:exosc5|EXOSC5]]|0.438|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.437|
|[[:human genes:c:cdca3|CDCA3]]|0.437|
|[[:human genes:t:tsg101|TSG101]]|0.437|
|[[:human genes:m:med29|MED29]]|0.437|
|[[:human genes:l:loc643669|LOC643669]]|0.437|
|[[:human genes:s:ssh2|SSH2]]|0.436|
|[[:human genes:c:cbwd6|CBWD6]]|0.436|
|[[:human genes:a:aamp|AAMP]]|0.436|
|[[:human genes:c:c14orf93|C14orf93]]|0.436|
|[[:human genes:i:iscu|ISCU]]|0.436|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.435|
|[[:human genes:p:paf1|PAF1]]|0.434|
|[[:human genes:a:ankle1|ANKLE1]]|0.434|
|[[:human genes:o:orc1|ORC1]]|0.433|
|[[:human genes:g:golga8o|GOLGA8O]]|0.432|
|[[:human genes:r:rps2|RPS2]]|0.432|
|[[:human genes:r:rps19|RPS19]]|0.431|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.431|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.431|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.431|
|[[:human genes:s:sart1|SART1]]|0.431|
|[[:human genes:u:utp3|UTP3]]|0.43|
|[[:human genes:p:prpf19|PRPF19]]|0.43|
|[[:human genes:c:cwc22|CWC22]]|0.43|
|[[:human genes:n:napa|NAPA]]|0.43|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.429|
|[[:human genes:f:fam160a1|FAM160A1]]|0.429|
|[[:human genes:n:npipb5|NPIPB5]]|0.429|
|[[:human genes:p:phf2|PHF2]]|0.428|
|[[:human genes:c:ccdc116|CCDC116]]|0.428|
|[[:human genes:r:rfc1|RFC1]]|0.428|
|[[:human genes:f:fbxw9|FBXW9]]|0.428|
|[[:human genes:p:psmb3|PSMB3]]|0.427|
|[[:human genes:p:psma7|PSMA7]]|0.427|
|[[:human genes:r:rps28|RPS28]]|0.427|
|[[:human genes:c:cdc73|CDC73]]|0.426|
|[[:human genes:x:xab2|XAB2]]|0.426|
|[[:human genes:r:rps12|RPS12]]|0.426|
|[[:human genes:d:dnm2|DNM2]]|0.425|
|[[:human genes:d:dhx38|DHX38]]|0.424|
|[[:human genes:n:nufip2|NUFIP2]]|0.424|
|[[:human genes:c:cgb2|CGB2]]|0.424|
|[[:human genes:s:sf3a1|SF3A1]]|0.423|
|[[:human genes:m:myo1h|MYO1H]]|0.422|
|[[:human genes:s:s1pr4|S1PR4]]|0.421|
|[[:human genes:d:ddtl|DDTL]]|0.421|
|[[:human genes:k:krt78|KRT78]]|0.421|
|[[:human genes:c:col2a1|COL2A1]]|0.42|
|[[:human genes:r:rps3|RPS3]]|0.419|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.419|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.419|
|[[:human genes:z:znf655|ZNF655]]|0.418|
|[[:human genes:s:snrnp200|SNRNP200]]|0.418|
|[[:human genes:f:fam231c|FAM231C]]|0.417|
|[[:human genes:k:kif3c|KIF3C]]|0.417|
|[[:human genes:c:chchd3|CHCHD3]]|0.417|
|[[:human genes:s:sap30bp|SAP30BP]]|0.417|
|[[:human genes:f:fancm|FANCM]]|0.417|
|[[:human genes:f:fam231a|FAM231A]]|0.417|
|[[:human genes:r:rbm39|RBM39]]|0.417|
|[[:human genes:s:skiv2l2|SKIV2L2]]|0.416|
|[[:human genes:i:ints5|INTS5]]|0.415|
|[[:human genes:m:mbtd1|MBTD1]]|0.415|
|[[:human genes:n:nol10|NOL10]]|0.415|
|[[:human genes:p:pola1|POLA1]]|0.415|
|[[:human genes:r:rad21|RAD21]]|0.414|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.414|
|[[:human genes:c:ctage9|CTAGE9]]|0.414|
|[[:human genes:a:acsf2|ACSF2]]|0.414|
|[[:human genes:h:hivep3|HIVEP3]]|0.413|
|[[:human genes:g:golga6a|GOLGA6A]]|0.413|
|[[:human genes:t:tagln|TAGLN]]|0.411|
|[[:human genes:a:aatf|AATF]]|0.411|
|[[:human genes:c:cdc6|CDC6]]|0.411|
|[[:human genes:r:rrp15|RRP15]]|0.41|
|[[:human genes:n:narfl|NARFL]]|0.409|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.409|
|[[:human genes:o:or10g3|OR10G3]]|0.409|
|[[:human genes:r:rpl37a|RPL37A]]|0.408|
|[[:human genes:a:atp6ap2|ATP6AP2]]|0.408|
|[[:human genes:s:specc1l|SPECC1L]]|0.408|
|[[:human genes:h:hist1h4b|HIST1H4B]]|0.407|
|[[:human genes:r:rpl30|RPL30]]|0.407|
|[[:human genes:s:sf3a3|SF3A3]]|0.407|
|[[:human genes:t:trappc11|TRAPPC11]]|0.407|
|[[:human genes:c:cdc45|CDC45]]|0.406|
|[[:human genes:g:gid4|GID4]]|0.406|
|[[:human genes:o:osbp|OSBP]]|0.405|
|[[:human genes:p:ppfia4|PPFIA4]]|0.405|
|[[:human genes:p:psmc3|PSMC3]]|0.405|
|[[:human genes:s:scgb1c1|SCGB1C1]]|0.405|
|[[:human genes:z:zfand5|ZFAND5]]|0.404|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.404|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.404|
|[[:human genes:e:eif6|EIF6]]|0.403|
|[[:human genes:s:snx15|SNX15]]|0.402|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.401|
|[[:human genes:p:polr2a|POLR2A]]|0.401|
|[[:human genes:e:exosc3|EXOSC3]]|0.401|
|[[:human genes:p:polr2d|POLR2D]]|0.4|
|[[:human genes:s:sema6b|SEMA6B]]|0.4|
|[[:human genes:s:stil|STIL]]|0.4|
|[[:human genes:t:tonsl|TONSL]]|0.4|
|[[:human genes:e:egr2|EGR2]]|0.4|
|[[:human genes:p:psmd11|PSMD11]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 667/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|23/28|
|bone|24/25|
|breast|31/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|14/15|
|kidney|17/21|
|liver|15/20|
|lung|68/75|
|lymphocyte|11/14|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|14/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|1/2|
|upper aerodigestive|17/22|
|urinary tract|24/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 128
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHAF1A Expression in NALM6 Cells: 7.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>