======= CHCHD10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHCHD10
  * **<color #00a2e8>Official Name</color>**: coiled-coil-helix-coiled-coil-helix domain containing 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=400916|400916]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WYQ3|Q8WYQ3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHCHD10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHCHD10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615903|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitochondrial protein that is enriched at cristae junctions in the intermembrane space. It may play a role in cristae morphology maintenance or oxidative phosphorylation. Mutations in this gene cause frontotemporal dementia and/or amyotrophic lateral sclerosis-2. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7 and 19. [provided by RefSeq, Aug 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. {ECO:0000269|PubMed:24934289}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CHCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleoid organization|
|mitochondrial nucleoid organization|
|positive regulation of mitochondrial transcription|
|positive regulation of cristae formation|
|regulation of cristae formation|
|positive regulation of cytochrome-c oxidase activity|
|regulation of mitochondrial transcription|
|positive regulation of electron transfer activity|
|regulation of cytochrome-c oxidase activity|
|regulation of electron transfer activity|
|MICOS complex|
|maintenance of synapse structure|
|stabilization of membrane potential|
|regulation of proton transport|
|regulation of mitochondrial gene expression|
|positive regulation of release of cytochrome c from mitochondria|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|cellular component maintenance|
|regulation of release of cytochrome c from mitochondria|
|positive regulation of oxidoreductase activity|
|regulation of mitochondrial membrane permeability|
|mitochondrial intermembrane space|
|regulation of membrane permeability|
|regulation of oxidoreductase activity|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|positive regulation of mitochondrion organization|
|oxidative phosphorylation|
|mitochondrial membrane organization|
|positive regulation of cation transmembrane transport|
|positive regulation of ion transmembrane transport|
|regulation of generation of precursor metabolites and energy|
|protein localization to nucleus|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|positive regulation of transmembrane transport|
|ATP metabolic process|
|mitochondrial transport|
|protein-containing complex disassembly|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|synapse organization|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of cation transmembrane transport|
|regulation of apoptotic signaling pathway|
|cellular component disassembly|
|generation of precursor metabolites and energy|
|regulation of membrane potential|
|mitochondrion organization|
|regulation of ion transmembrane transport|
|regulation of transmembrane transport|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulation of ion transport|
|protein localization to organelle|
|molecular function|
|membrane organization|
|positive regulation of transport|
|positive regulation of cellular component organization|
|mitochondrion|
|phosphorylation|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10837
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHCHD10 Expression in NALM6 Cells: 4.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>