======= CHCHD3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHCHD3
  * **<color #00a2e8>Official Name</color>**: coiled-coil-helix-coiled-coil-helix domain containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54927|54927]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NX63|Q9NX63]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHCHD3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHCHD3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613748|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180). {ECO:0000269|PubMed:22567091, ECO:0000269|PubMed:25781180}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF737|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|MICOS complex|
|mitochondrial fusion|
|cristae formation|
|inner mitochondrial membrane organization|
|molecular adaptor activity|
|phosphatase binding|
|organelle fusion|
|mitochondrial membrane organization|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|mitochondrial inner membrane|
|mitochondrion organization|
|membrane organization|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.85|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-1.74|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.76|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.8|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.606|
|[[:human genes:c:cbwd3|CBWD3]]|0.478|
|[[:human genes:r:rps12|RPS12]]|0.477|
|[[:human genes:m:mbtd1|MBTD1]]|0.475|
|[[:human genes:o:ogfr|OGFR]]|0.465|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.464|
|[[:human genes:c:cdc45|CDC45]]|0.461|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.46|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.46|
|[[:human genes:p:psma6|PSMA6]]|0.458|
|[[:human genes:n:npipb11|NPIPB11]]|0.454|
|[[:human genes:d:disp2|DISP2]]|0.453|
|[[:human genes:c:cbwd5|CBWD5]]|0.452|
|[[:human genes:z:zfand5|ZFAND5]]|0.451|
|[[:human genes:l:lad1|LAD1]]|0.45|
|[[:human genes:r:rpl35|RPL35]]|0.447|
|[[:human genes:p:pola1|POLA1]]|0.446|
|[[:human genes:r:rps19|RPS19]]|0.443|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.44|
|[[:human genes:p:psmb4|PSMB4]]|0.435|
|[[:human genes:c:cbwd6|CBWD6]]|0.433|
|[[:human genes:t:tyms|TYMS]]|0.431|
|[[:human genes:n:npipb5|NPIPB5]]|0.43|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.43|
|[[:human genes:a:aatf|AATF]]|0.428|
|[[:human genes:p:psmb2|PSMB2]]|0.428|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.426|
|[[:human genes:r:rad21|RAD21]]|0.424|
|[[:human genes:m:med17|MED17]]|0.424|
|[[:human genes:p:psmd3|PSMD3]]|0.424|
|[[:human genes:t:tceb3c|TCEB3C]]|0.422|
|[[:human genes:p:pole|POLE]]|0.421|
|[[:human genes:r:ranbp2|RANBP2]]|0.421|
|[[:human genes:t:twistnb|TWISTNB]]|0.42|
|[[:human genes:s:smg1|SMG1]]|0.42|
|[[:human genes:p:psmd11|PSMD11]]|0.42|
|[[:human genes:r:rps5|RPS5]]|0.419|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.418|
|[[:human genes:c:chaf1a|CHAF1A]]|0.417|
|[[:human genes:h:hap1|HAP1]]|0.415|
|[[:human genes:p:psmc2|PSMC2]]|0.415|
|[[:human genes:w:wdr43|WDR43]]|0.415|
|[[:human genes:c:cactin|CACTIN]]|0.414|
|[[:human genes:p:pola2|POLA2]]|0.414|
|[[:human genes:n:nup160|NUP160]]|0.411|
|[[:human genes:p:psmd14|PSMD14]]|0.411|
|[[:human genes:r:rrp7a|RRP7A]]|0.411|
|[[:human genes:r:rps2|RPS2]]|0.41|
|[[:human genes:p:psma1|PSMA1]]|0.41|
|[[:human genes:p:pan2|PAN2]]|0.409|
|[[:human genes:r:rbbp5|RBBP5]]|0.407|
|[[:human genes:u:utp20|UTP20]]|0.406|
|[[:human genes:c:copg1|COPG1]]|0.406|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.405|
|[[:human genes:u:upf1|UPF1]]|0.404|
|[[:human genes:f:fam160a1|FAM160A1]]|0.404|
|[[:human genes:t:ticrr|TICRR]]|0.401|
|[[:human genes:c:ccna2|CCNA2]]|0.401|
|[[:human genes:p:ppp1r15b|PPP1R15B]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2010
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHCHD3 Expression in NALM6 Cells: 6.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>