======= CHD7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHD7
  * **<color #00a2e8>Official Name</color>**: chromodomain helicase DNA binding protein 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55636|55636]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P2D1|Q9P2D1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHD7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHD7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608892|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that contains several helicase family domains. Mutations in this gene have been found in some patients with the CHARGE syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Chromo|
|Helicase C|
|SNF2 N|
|BRK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|right ventricular compact myocardium morphogenesis|
|right ventricular cardiac muscle tissue morphogenesis|
|olfactory nerve development|
|atrioventricular canal development|
|semicircular canal morphogenesis|
|ventricular compact myocardium morphogenesis|
|semicircular canal development|
|olfactory behavior|
|regulation of growth hormone secretion|
|adult heart development|
|nose development|
|ventricular trabecula myocardium morphogenesis|
|female genitalia development|
|chemosensory behavior|
|cardiac right ventricle morphogenesis|
|secondary palate development|
|innervation|
|aorta morphogenesis|
|embryonic hindlimb morphogenesis|
|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|adult walking behavior|
|walking behavior|
|positive regulation of multicellular organism growth|
|blood vessel remodeling|
|olfactory bulb development|
|heart trabecula morphogenesis|
|olfactory lobe development|
|hindlimb morphogenesis|
|trabecula morphogenesis|
|genitalia development|
|ventricular cardiac muscle tissue morphogenesis|
|face development|
|promoter-specific chromatin binding|
|cranial nerve development|
|aorta development|
|ventricular cardiac muscle tissue development|
|DNA helicase activity|
|artery morphogenesis|
|regulation of multicellular organism growth|
|cardiac muscle tissue morphogenesis|
|cardiac septum morphogenesis|
|cardiac ventricle morphogenesis|
|adult locomotory behavior|
|regulation of release of sequestered calcium ion into cytosol|
|nerve development|
|muscle tissue morphogenesis|
|artery development|
|muscle organ morphogenesis|
|roof of mouth development|
|inner ear morphogenesis|
|regulation of calcium ion transport into cytosol|
|tissue remodeling|
|female sex differentiation|
|cardiac septum development|
|DNA duplex unwinding|
|ear morphogenesis|
|DNA geometric change|
|regulation of sequestering of calcium ion|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|T cell differentiation|
|retina development in camera-type eye|
|adult behavior|
|sensory perception of sound|
|regulation of calcium ion transmembrane transport|
|limb morphogenesis|
|appendage morphogenesis|
|chromatin remodeling|
|cardiac muscle tissue development|
|sensory perception of mechanical stimulus|
|cardiac chamber development|
|positive regulation of developmental growth|
|limb development|
|appendage development|
|inner ear development|
|locomotory behavior|
|respiratory system development|
|regulation of peptide hormone secretion|
|rRNA processing|
|ear development|
|rRNA metabolic process|
|T cell activation|
|lymphocyte differentiation|
|regulation of calcium ion transport|
|heart morphogenesis|
|sensory organ morphogenesis|
|telencephalon development|
|positive regulation of growth|
|sex differentiation|
|regulation of hormone secretion|
|striated muscle tissue development|
|embryonic organ morphogenesis|
|muscle organ development|
|muscle tissue development|
|DNA conformation change|
|cognition|
|ribosome biogenesis|
|camera-type eye development|
|regulation of developmental growth|
|leukocyte differentiation|
|regulation of cation transmembrane transport|
|eye development|
|visual system development|
|sensory system development|
|in utero embryonic development|
|lymphocyte activation|
|ncRNA processing|
|forebrain development|
|regulation of metal ion transport|
|blood circulation|
|chromatin binding|
|circulatory system process|
|blood vessel morphogenesis|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|muscle structure development|
|regulation of ion transmembrane transport|
|blood vessel development|
|regulation of peptide secretion|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|cardiovascular system development|
|heart development|
|regulation of hormone levels|
|sensory organ development|
|hemopoiesis|
|regulation of transmembrane transport|
|tissue morphogenesis|
|embryonic morphogenesis|
|behavior|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|regulation of growth|
|response to bacterium|
|chromatin organization|
|regulation of ion transport|
|regulation of peptide transport|
|brain development|
|regulation of secretion by cell|
|head development|
|regulation of secretion|
|regulation of neurogenesis|
|tube development|
|nucleolus|
|circulatory system development|
|RNA processing|
|regulation of cellular localization|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|animal organ morphogenesis|
|sensory perception|
|embryo development|
|central nervous system development|
|chromosome organization|
|cell activation|
|epithelium development|
|positive regulation of transcription by RNA polymerase II|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|positive regulation of developmental process|
|nervous system process|
|reproductive process|
|reproduction|
|ATP binding|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.11|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.1|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.98|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.86|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-1.77|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.72|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.72|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.81|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.82|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.85|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.94|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.01|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|2.02|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.04|
|[[:results:exp483|FTY720 3μM R08 exp483]]|2.08|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.12|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.14|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.26|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.36|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.51|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.88|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.35|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|4.89|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|5.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:spop|SPOP]]|0.441|
|[[:human genes:c:casp3|CASP3]]|0.424|
|[[:human genes:t:tnfrsf10b|TNFRSF10B]]|0.413|
|[[:human genes:i:ikzf1|IKZF1]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4362
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHD7 Expression in NALM6 Cells: 8.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>