======= CHMP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHMP3
  * **<color #00a2e8>Official Name</color>**: charged multivesicular body protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51652|51652]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3E7|Q9Y3E7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHMP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHMP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610052|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Snf7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|multivesicular body-lysosome fusion|
|endosome to lysosome transport via multivesicular body sorting pathway|
|ESCRT III complex|
|positive regulation of viral release from host cell|
|negative regulation of viral release from host cell|
|midbody abscission|
|late endosome to vacuole transport|
|ubiquitin-specific protease binding|
|regulation of early endosome to late endosome transport|
|regulation of exosomal secretion|
|viral budding via host ESCRT complex|
|mitotic cytokinetic process|
|regulation of mitotic spindle assembly|
|regulation of cytoplasmic transport|
|viral budding|
|endosome transport via multivesicular body sorting pathway|
|phosphatidylcholine binding|
|regulation of spindle assembly|
|multivesicular body assembly|
|multivesicular body organization|
|regulation of viral release from host cell|
|multivesicular body|
|autophagosome maturation|
|multivesicular body sorting pathway|
|cytokinetic process|
|virion assembly|
|regulation of mitotic spindle organization|
|regulation of centrosome duplication|
|regulation of spindle organization|
|mitotic metaphase plate congression|
|endosome to lysosome transport|
|metaphase plate congression|
|regulation of centrosome cycle|
|positive regulation of viral life cycle|
|mitotic cytokinesis|
|establishment of chromosome localization|
|chromosome localization|
|endosome organization|
|organelle membrane fusion|
|negative regulation of viral life cycle|
|protein polymerization|
|organelle fusion|
|cytoskeleton-dependent cytokinesis|
|negative regulation of viral process|
|cytokinesis|
|lysosomal transport|
|protein heterooligomerization|
|positive regulation of viral process|
|mitotic sister chromatid segregation|
|late endosome membrane|
|late endosome|
|membrane fusion|
|nucleus organization|
|sister chromatid segregation|
|vacuolar transport|
|regulation of viral life cycle|
|mitotic nuclear division|
|macroautophagy|
|regulation of mitotic nuclear division|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|viral life cycle|
|regulation of viral process|
|negative regulation of multi-organism process|
|nuclear chromosome segregation|
|regulation of organelle assembly|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of microtubule-based process|
|regulation of exocytosis|
|endosomal transport|
|protein-containing complex disassembly|
|cytoplasmic vesicle|
|autophagy|
|process utilizing autophagic mechanism|
|chromosome segregation|
|nuclear division|
|vesicle organization|
|organelle fission|
|negative regulation of locomotion|
|regulation of intracellular transport|
|establishment of organelle localization|
|cellular component disassembly|
|endomembrane system organization|
|cell division|
|positive regulation of multi-organism process|
|protein complex oligomerization|
|regulation of cytoskeleton organization|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|viral process|
|regulation of secretion by cell|
|regulation of cell cycle process|
|organelle assembly|
|regulation of multi-organism process|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|membrane organization|
|protein homodimerization activity|
|regulation of cellular localization|
|apoptotic process|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|cell cycle process|
|programmed cell death|
|chromosome organization|
|cell death|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|establishment of protein localization|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.92|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.84|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.84|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.83|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.83|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.79|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.75|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.664|
|[[:human genes:p:polr2j3|POLR2J3]]|0.495|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 175/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|7/28|
|blood|8/28|
|bone|6/26|
|breast|8/33|
|central nervous system|19/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|1/1|
|gastric|3/16|
|kidney|5/21|
|liver|1/20|
|lung|16/75|
|lymphocyte|7/16|
|ovary|4/26|
|pancreas|5/24|
|peripheral nervous system|11/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|4/9|
|thyroid|1/2|
|upper aerodigestive|7/22|
|urinary tract|8/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2094
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHMP3 Expression in NALM6 Cells: 4.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>