======= CHMP4A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHMP4A
  * **<color #00a2e8>Official Name</color>**: charged multivesicular body protein 4A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29082|29082]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BY43|Q9BY43]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHMP4A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHMP4A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610051|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:12860994, ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:14583093, ECO:0000269|PubMed:18209100, ECO:0000269|PubMed:22660413}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Snf7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|membrane coat|
|ESCRT III complex|
|posttranslational protein targeting to endoplasmic reticulum membrane|
|negative regulation of autophagosome assembly|
|plasma membrane tubulation|
|midbody abscission|
|viral budding via host ESCRT complex|
|mitotic cytokinetic process|
|viral budding|
|multivesicular body assembly|
|multivesicular body organization|
|negative regulation of macroautophagy|
|regulation of autophagosome assembly|
|cytokinetic process|
|virion assembly|
|negative regulation of organelle assembly|
|regulation of vacuole organization|
|mitotic metaphase plate congression|
|cytoplasmic side of plasma membrane|
|metaphase plate congression|
|mitotic cytokinesis|
|establishment of chromosome localization|
|chromosome localization|
|endosome organization|
|ATPase binding|
|negative regulation of autophagy|
|protein polymerization|
|plasma membrane organization|
|vesicle budding from membrane|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|mitotic sister chromatid segregation|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|late endosome membrane|
|nucleus organization|
|protein localization to endoplasmic reticulum|
|sister chromatid segregation|
|vacuolar transport|
|cytoplasmic vesicle membrane|
|membrane invagination|
|mitotic nuclear division|
|lipid binding|
|midbody|
|protein targeting to membrane|
|macroautophagy|
|regulation of macroautophagy|
|viral life cycle|
|negative regulation of neuron death|
|nuclear chromosome segregation|
|regulation of organelle assembly|
|endosomal transport|
|negative regulation of cellular catabolic process|
|autophagy|
|process utilizing autophagic mechanism|
|establishment of protein localization to membrane|
|endosome|
|chromosome segregation|
|nuclear division|
|vesicle organization|
|negative regulation of catabolic process|
|regulation of neuron death|
|organelle fission|
|regulation of autophagy|
|protein homooligomerization|
|protein targeting|
|establishment of organelle localization|
|negative regulation of organelle organization|
|endomembrane system organization|
|establishment of protein localization to organelle|
|protein localization to membrane|
|cell division|
|protein complex oligomerization|
|organelle localization|
|mitotic cell cycle process|
|mitotic cell cycle|
|viral process|
|negative regulation of cellular component organization|
|protein localization to organelle|
|organelle assembly|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|membrane organization|
|protein homodimerization activity|
|regulation of cellular component biogenesis|
|intracellular protein transport|
|regulation of catabolic process|
|negative regulation of cell death|
|cell cycle process|
|chromosome organization|
|identical protein binding|
|regulation of organelle organization|
|cell cycle|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell death|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.97|
|[[:results:exp453|B02 10μM R08 exp453]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4046
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHMP4A Expression in NALM6 Cells: 4.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>