======= CHMP4B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHMP4B
  * **<color #00a2e8>Official Name</color>**: charged multivesicular body protein 4B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=128866|128866]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H444|Q9H444]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHMP4B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHMP4B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610897|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:12860994, ECO:0000269|PubMed:18209100, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:26040712}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Snf7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maintenance of lens transparency|
|ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway|
|membrane coat|
|ESCRT III complex|
|posttranslational protein targeting to endoplasmic reticulum membrane|
|membrane fission|
|negative regulation of autophagosome assembly|
|exit from mitosis|
|positive regulation of viral release from host cell|
|midbody abscission|
|nuclear envelope reassembly|
|viral budding via host ESCRT complex|
|mitotic cytokinetic process|
|regulation of mitotic spindle assembly|
|viral budding|
|regulation of spindle assembly|
|multivesicular body assembly|
|regulation of viral release from host cell|
|multivesicular body organization|
|negative regulation of macroautophagy|
|regulation of autophagosome assembly|
|cytokinetic process|
|negative regulation of organelle assembly|
|virion assembly|
|regulation of mitotic spindle organization|
|regulation of vacuole organization|
|regulation of spindle organization|
|regulation of centrosome duplication|
|mitotic metaphase plate congression|
|cytoplasmic side of plasma membrane|
|nuclear envelope organization|
|metaphase plate congression|
|regulation of centrosome cycle|
|positive regulation of viral life cycle|
|mitotic cytokinesis|
|establishment of chromosome localization|
|chromosome localization|
|endosome organization|
|negative regulation of autophagy|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|positive regulation of viral process|
|mitotic sister chromatid segregation|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|late endosome membrane|
|nucleus organization|
|protein localization to endoplasmic reticulum|
|vesicle|
|vacuolar transport|
|sister chromatid segregation|
|regulation of viral life cycle|
|mitotic nuclear division|
|midbody|
|protein targeting to membrane|
|macroautophagy|
|regulation of mitotic nuclear division|
|regulation of macroautophagy|
|nuclear envelope|
|regulation of microtubule cytoskeleton organization|
|tissue homeostasis|
|regulation of nuclear division|
|viral life cycle|
|regulation of viral process|
|negative regulation of neuron death|
|nuclear chromosome segregation|
|regulation of organelle assembly|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of microtubule-based process|
|endosomal transport|
|negative regulation of cellular catabolic process|
|autophagy|
|process utilizing autophagic mechanism|
|establishment of protein localization to membrane|
|mitotic cell cycle phase transition|
|endosome|
|chromosome segregation|
|cell cycle phase transition|
|nuclear division|
|vesicle organization|
|negative regulation of catabolic process|
|cadherin binding|
|regulation of neuron death|
|organelle fission|
|multicellular organismal homeostasis|
|regulation of autophagy|
|protein homooligomerization|
|anatomical structure homeostasis|
|protein targeting|
|establishment of organelle localization|
|negative regulation of organelle organization|
|endomembrane system organization|
|establishment of protein localization to organelle|
|protein localization to membrane|
|cell division|
|positive regulation of multi-organism process|
|protein complex oligomerization|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|organelle localization|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|protein catabolic process|
|viral process|
|negative regulation of cellular component organization|
|protein localization to organelle|
|regulation of cell cycle process|
|organelle assembly|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|membrane organization|
|protein homodimerization activity|
|cellular macromolecule catabolic process|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|regulation of catabolic process|
|negative regulation of cell death|
|intracellular protein transport|
|cell cycle process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|identical protein binding|
|regulation of cell cycle|
|proteolysis|
|regulation of organelle organization|
|cell cycle|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|regulation of cell death|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.74|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.41|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.39|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.24|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-2.11|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.06|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-2.02|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.91|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.85|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.83|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.83|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.83|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.8|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.78|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.77|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.7|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.7|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.7|
|[[:results:exp132|Metformin 40μM R03 exp132]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.545|
|[[:human genes:c:cdc45|CDC45]]|0.492|
|[[:human genes:i:ik|IK]]|0.487|
|[[:human genes:c:copz1|COPZ1]]|0.484|
|[[:human genes:p:psmb4|PSMB4]]|0.474|
|[[:human genes:p:polr2a|POLR2A]]|0.466|
|[[:human genes:s:slc6a17|SLC6A17]]|0.461|
|[[:human genes:p:psma6|PSMA6]]|0.46|
|[[:human genes:p:psmb3|PSMB3]]|0.46|
|[[:human genes:a:ankle2|ANKLE2]]|0.458|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.454|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.453|
|[[:human genes:p:psmc2|PSMC2]]|0.453|
|[[:human genes:c:cdt1|CDT1]]|0.452|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.452|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.452|
|[[:human genes:s:supt5h|SUPT5H]]|0.452|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.45|
|[[:human genes:i:ints1|INTS1]]|0.449|
|[[:human genes:z:zfand5|ZFAND5]]|0.444|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.444|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.443|
|[[:human genes:t:twistnb|TWISTNB]]|0.442|
|[[:human genes:t:tspy2|TSPY2]]|0.439|
|[[:human genes:p:polr2d|POLR2D]]|0.438|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.437|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.435|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.434|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.433|
|[[:human genes:m:mfsd12|MFSD12]]|0.431|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.43|
|[[:human genes:c:ctage4|CTAGE4]]|0.429|
|[[:human genes:u:utp3|UTP3]]|0.428|
|[[:human genes:k:kctd17|KCTD17]]|0.428|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.427|
|[[:human genes:p:polr1a|POLR1A]]|0.427|
|[[:human genes:o:osbp|OSBP]]|0.427|
|[[:human genes:r:rpl9|RPL9]]|0.426|
|[[:human genes:d:dtl|DTL]]|0.424|
|[[:human genes:r:ranbp2|RANBP2]]|0.424|
|[[:human genes:u:usp5|USP5]]|0.423|
|[[:human genes:i:ints6|INTS6]]|0.423|
|[[:human genes:p:psmc1|PSMC1]]|0.422|
|[[:human genes:r:rpl35|RPL35]]|0.421|
|[[:human genes:a:ankle1|ANKLE1]]|0.418|
|[[:human genes:n:nelfa|NELFA]]|0.417|
|[[:human genes:t:tspy8|TSPY8]]|0.416|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.415|
|[[:human genes:s:sbno1|SBNO1]]|0.414|
|[[:human genes:c:cactin|CACTIN]]|0.413|
|[[:human genes:a:aatf|AATF]]|0.411|
|[[:human genes:c:cbwd3|CBWD3]]|0.411|
|[[:human genes:c:cep192|CEP192]]|0.411|
|[[:human genes:n:narfl|NARFL]]|0.409|
|[[:human genes:e:exosc9|EXOSC9]]|0.409|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.409|
|[[:human genes:r:rpa2|RPA2]]|0.409|
|[[:human genes:e:exosc3|EXOSC3]]|0.408|
|[[:human genes:r:rrp7a|RRP7A]]|0.407|
|[[:human genes:a:akirin2|AKIRIN2]]|0.407|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.407|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.406|
|[[:human genes:n:nup43|NUP43]]|0.405|
|[[:human genes:c:chd4|CHD4]]|0.405|
|[[:human genes:s:supt6h|SUPT6H]]|0.405|
|[[:human genes:t:tceb3c|TCEB3C]]|0.404|
|[[:human genes:r:rpl8|RPL8]]|0.403|
|[[:human genes:r:rrn3|RRN3]]|0.403|
|[[:human genes:h:hap1|HAP1]]|0.403|
|[[:human genes:t:top1mt|TOP1MT]]|0.403|
|[[:human genes:d:dock6|DOCK6]]|0.402|
|[[:human genes:p:psmd7|PSMD7]]|0.402|
|[[:human genes:t:trappc11|TRAPPC11]]|0.401|
|[[:human genes:n:nsf|NSF]]|0.401|
|[[:human genes:s:snip1|SNIP1]]|0.401|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.4|
|[[:human genes:d:ddtl|DDTL]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 410/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|7/28|
|blood|23/28|
|bone|20/26|
|breast|14/33|
|central nervous system|51/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|5/13|
|fibroblast|1/1|
|gastric|6/16|
|kidney|17/21|
|liver|10/20|
|lung|38/75|
|lymphocyte|8/16|
|ovary|9/26|
|pancreas|7/24|
|peripheral nervous system|15/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|21/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|8/22|
|urinary tract|11/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 649
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHMP4B Expression in NALM6 Cells: 5.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>